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T-5224

109 Cited Publications
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Based on 109 publication(s) in Google Scholar

T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.

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  • Purity: 99.35%
  • CAS No.: 530141-72-1
  • 화학식: C29H27NO8
  • 분자량:517.53
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • T-5224 Chemical Structure
    T-5224 Chemical Structure
  • Experimental Validation Results for T-5224
  • Experimental Validation Results for T-5224
  • Experimental Validation Results for T-5224
  • Experimental Validation Results for T-5224
  • Experimental Validation Results for T-5224
CAS No.: 530141-72-1
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  • T-5224 Chemical Structure
    T-5224 Chemical Structure
    1/16
  • 1/16

    T-5224 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 28;10(1):357. [Abstract]

    Customer Validation
     WT and KO BMMSCs were treated with the AP-1-specific inhibitor T-5224 (10 μM) for 24 h.

  • 1/16

    T-5224 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Mar 25;9(1):74. [Abstract]

    Customer Validation
     Quantitative real-time PCR analyses showing the effect of C29 (50 μM), SP600125 (10 μM) and the selective AP-1 inhibitor T-5224 (10 μM) on the expression of tumor necrosis factor-α (TNF-α) in BEAS-2B cells stimulated with E protein (50 μg/mL) for 12 h.

  • 1/16

    T-5224 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Jul 11;7(1):222. [Abstract]

    Customer Validation
     The expression of CDK2 in the splenic cells of mice treated with DHA alone, DHA with the T-5224 inhibitor and CMC control was examined with specific antibodies. The upregulatory effect of DHA on CDK2 was significantly inhibited by T-5224 (30 mg/kg; per day by oral gavage for 8 days), a specific inhibitor of C-Fos. Molecular weight (kDa) was labeled at the right.

  • 1/16

    T-5224 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Sep:155:275-287. [Abstract]

    Customer Validation
     Twist1, nuclear NF-κB-p65 and secreted TNF-α in macrophages after transfection with Twist1 siRNA (100 pmol/well) for 48 h and then treatment with LPS, TT-TFM (200 μM) and T5224 (50 μM) for another 24 h.

  • 1/16

    T-5224 purchased from MedChemExpress. Usage Cited in: Endocrinology. 2017 Nov 1;158(11):4064-4075. [Abstract]

    Customer Validation
     Cyp27b1 induction by LPS or TNF-α is mediated by NF-κB. HCT116 cells are treated with 100 ng/mL LPS or 100 ng/mL TNF-α overnight in the presence or absence of 20 ng/mL T-5224 as indicated. Cyp27b1 protein levels are measured by Western blotting.

  • T-5224