Antcin K
Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates IL-10 expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 741268-13-3
- 화학식: C29H44O6
- 분자량:488.66
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All AP-1 Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | ED50 |
>20 μg/mL
Compound: 32
|
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
|
[PMID: 21115251] |
| HEp-2 | ED50 |
>20 μg/mL
Compound: 32
|
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
|
[PMID: 21115251] |
| MCF7 | ED50 |
>20 μg/mL
Compound: 32
|
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
|
[PMID: 21115251] |
Chemical Information
-
CAS No. 741268-13-3
-
분자량 488.66
-
화학식 C29H44O6
-
SMILES
C[C@@]12C3=C([C@H](C[C@@]1([H])[C@@](O)([C@@H](CC2)O)C)O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
-
Structure Classification
-
Initial Source
Antrodia cinnamomea
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Wu YH, et al. Antcin K suppresses proinflammatory cytokines expression via the PI3K, Akt and NF-κB pathways in human gingival fibroblasts: implications for periodontitis treatment. Cell Death Discov. 2025 Nov 22. [Content Brief]
[2]. Achudhan D, et al. Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts. Food Nutr Res. 2022 Jun 2;66. [Content Brief]
[3]. Chang TK, et al. Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation. Int J Biol Sci. 2025 Mar 19;21(6):2493-2507. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antcin K Related Classifications
HY-N9980 Related Classifications
Powered by Bioz