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Cat. No.: HY-N19215

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Arnicolide B

Arnicolide B is a sesquiterpene lactone. Arnicolide B is isolated from Centipeda minima. Arnicolide B inhibits the phosphorylation of ERK, JNK and p38 proteins in the MAPK signaling pathway. Arnicolide B reduces the production of inflammatory mediators NO, PGE₂ and IL-6. Arnicolide B downregulates the overexpression of inflammatory proteins iNOS and COX-2. Arnicolide B has no effect on IκB-α degradation or NF-κB pathway activation. Arnicolide B is applicable to inflammation-related research.

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CAS No.: 34532-66-6
화학식: C₂₀H₂₈O₅
분자량:348.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Arnicolide B Chemical Structure

CAS No.: 34532-66-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

iNOS

COX-2

IL-6

All p38 MAPK Isoforms :

All ERK Isoforms :

All JNK Isoforms :

All NO Synthase Isoforms :

All Interleukin Related Isoforms :

All COX Isoforms :

In Vitro

Arnicolide B (0.78-100 μM; 24 h) shows no cytotoxicity against RAW 264.7 cells at concentrations ≤6.25 μM^[1].
Arnicolide B (0.78-6.25 μM; 24 h) dose-dependently inhibits LPS-induced excessive NO production in RAW 264.7 macrophages^[1].
Arnicolide B (0.78-6.25 μM; 24 h) dose-dependently downregulates LPS-induced overexpression of iNOS and COX-2 in RAW 264.7 macrophages^[1].
Arnicolide B (0.78-6.25 μM; 10 min) exerts no significant inhibitory effect on LPS-induced IκB-α degradation in RAW 264.7 macrophages, indicating that it has no impact on the NF-κB pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS-activated mouse monocyte-macrophage RAW 264.7 cells
Concentration:

0.78-6.25 μM
Incubation Time:

24 h
Result:

Reduced LPS-induced iNOS expression at 0.78 μM.
Reduced LPS-induced iNOS expression at 1.56 μM.
Reduced LPS-induced iNOS expression at 3.12 μM.
Reduced LPS-induced iNOS expression 6.25 μM.
Reduced LPS-induced COX-2 expression.

Western Blot Analysis^[1]

Cell Line:

LPS-activated mouse monocyte-macrophage RAW 264.7 cells
Concentration:

0.78-6.25 μM
Incubation Time:

10 min
Result:

Did not alter LPS-induced IκB-α degradation, with IκB-α expression remaining at ~15-20% relative to β-actin, similar to the LPS-only group.

Chemical Information

CAS No. 34532-66-6
분자량 348.44
화학식 C₂₀H₂₈O₅
SMILES

O(C(CC(C)C)=O)[C@H]1[C@]2([C@@](C[C@@H](C)[C@]3([C@@]1(C)C(=O)C=C3)[H])(OC(=O)[C@H]2C)[H])[H]
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang G, et al. Two sesquiterpene lactones, arnicolide B and arnicolide C, isolated from Centipeda minima, exert anti-inflammatory effects in LPS stimulated RAW 264.7 macrophages via inactivation of the MAPK pathway. Nat Prod Res. 2023 Aug-Sep;37(17):2969-2972. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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Purity:
수량:

Arnicolide B

All p38 MAPK Isoforms

All ERK Isoforms

All JNK Isoforms

All NO Synthase Isoforms

All Interleukin Related Isoforms

All COX Isoforms