C1A
C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1021463-02-4
- 화학식: C22H25Cl2N3O4S
- 분자량:498.42
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
HDAC6 0.48 μM (IC50) |
HDAC8 0.61 μM (IC50) |
HDAC3 5.5 μM (IC50) |
HDAC10 9.8 μM (IC50) |
HDAC2 11 μM (IC50) |
HDAC1 14 μM (IC50) |
HDAC5 15 μM (IC50) |
HDAC4 16 μM (IC50) |
HDAC7 49 μM (IC50) |
HDAC9 56 μM (IC50) |
SIRT3 55 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KMS-11 | GI50 |
0.48 μM
Compound: 22
|
Antiproliferative activity against human KMS-11 cells incubated for 72 hrs by sulphorhodamine B assay
Antiproliferative activity against human KMS-11 cells incubated for 72 hrs by sulphorhodamine B assay
|
[PMID: 29133060] |
| SH-SY5Y | IC50 |
0.28 μM
Compound: 22
|
Antiproliferative activity against human SH-SY5Y cells incubated for 72 hrs by sulphorhodamine B assay
Antiproliferative activity against human SH-SY5Y cells incubated for 72 hrs by sulphorhodamine B assay
|
[PMID: 29133060] |
C1A (2.5-10 μM; 24 h) increases the sub-G1 population in a drug concentration-related manner. And C1A induces apoptosis and inhibits proliferation of a panel of human tumour cell lines from different origins in the low micromolar range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT-116 cells
-
Concentration:2.5 μM, 5 μM, 7.5 μM, 10 μM
-
Incubation Time:24 h
-
Result:Increased the sub-G1 population in a drug concentration-related manner.
-
Cell Line:HCT-116 cells
-
Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM
-
Incubation Time:4 h and 24 h
-
Result:Induced sustained acetylation of HDAC6 substrates, α-tubulin and HSP90.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female nu/nu-BALB/c mice injected with HCT-116 cells[1]
-
Dosage:20 mg/kg, 40 mg/kg
-
Administration:ip; once a day, twice a day, once every two days; for 14 days
-
Result:Inhibited the growth of colon tumours in vivo.
Chemical Information
-
CAS No. 1021463-02-4
-
분자량 498.42
-
화학식 C22H25Cl2N3O4S
-
SMILES
ClCCN(C1=CC=C(C=C1)S(NC2=CC=C(C=C2)/C=C(C)/C=C/C(NO)=O)(=O)=O)CCCl
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C1A Related Classifications
HY-124946 Related Classifications
Powered by Bioz