EGFR-IN-182
EGFR-IN-182 (Compound 4) is an EGFR inhibitor with an IC50 value of 199 nM. EGFR-IN-182 inhibits HSP90 and PI3K, with IC50 values of 5.007 and 13.596 μM respectively. EGFR-IN-182 exhibits strong anti-proliferative activity against MCF-7 and MDA-MB-231 cells. EGFR-IN-182 downregulates Cyclin D1, inducing cell cycle arrest; it enhances the activity of caspase-9, inducing cell apoptosis. EGFR-IN-182 downregulates the expressions of ERK and AKT. EGFR-IN-182 can be used for research on breast cancer.
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- 화학식: C25H18N8
- 분자량:430.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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EGFR 199 nM (IC50) |
HSP90 5.007 μM (IC50) |
PI3K 13.596 μM (IC50) |
Caspase 9 |
ERK |
Akt |
Chemical Information
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분자량 430.46
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화학식 C25H18N8
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SMILES
N1(CC2=CC=CC=C2)C3=NC(N/N=C/C4=NC(C=CC=C5)=C5N=C4)=NN=C3C6=C1C=CC=C6
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-182 Related Classifications
HY-178955 Related Classifications
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- EGFR-IN-182
- EGFR
- HSP
- PI3K
- Caspase
- Apoptosis
- CDK
- ERK
- Akt
- Triazino[5,6-b]indole-hydrazones
- Triazino[5,6-b]indole-fused heterocyclic hybrids
- EGFR enzyme inhibition
- Hsp90 inhibition
- PI3K-AKT signaling
- ERK/AKT signaling
- Caspase-9 activation
- In silico docking study
- Cancer drug design
- Multi-target inhibitors in cancer therapy
- Inhibitor
- inhibitor
- inhibit