TMX-2138
Based on 1 Customer Validation
TMX-2138 is a CDK PROTAC degrader, with IC50 values against different targets as follows: CDK1 (IC50 = 8.7 nM), CDK2 (IC50 = 10.9 nM), CDK5 (IC50 = 7.0 nM), CDK4 (IC50 = 901.0 nM), CDK6 (IC50 = 465.0 nM), CDK7 (IC50 = 286.0 nM), and CDK9 (IC50 = 25.7 nM). TMX-2138 promotes the ubiquitination of CDK and induces its degradation via the proteasomal pathway. TMX-2138 can be used in ovarian cancer research.
(Pink: CDK ligand (HY-151071); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W008352)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.99%
- CAS No.: 2488892-07-3
- 화학식: C40H43BrFN9O11S
- 분자량:956.79
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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CDK1/cyclinB 8.7 nM (IC50) |
CDK2/cyclinA 10.9 nM (IC50) |
Cdk5/p25 7.0 nM (IC50) |
CDK9/cyclinT1 25.7 nM (IC50) |
CDK4/cyclinD1 901 nM (IC50) |
CDK6/cyclinD1 465 nM (IC50) |
CDK7/cyclin H 286 nM (IC50) |
TMX-2138 (10-point dose response) potently inhibits purified human CDK1/cyclin B (IC50 = 8.7 nM), CDK2/cyclin A (IC50 = 10.9 nM), CDK5/p25 (IC50 = 7.0 nM), and CDK9/cyclin T1 (IC50 = 25.7 nM), while showing much weaker activity against CDK4/cyclin D1, CDK6/cyclin D1, and CDK7/cyclin H/MNAT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2488892-07-3
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Appearance Solid
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분자량 956.79
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화학식 C40H43BrFN9O11S
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Color White to light yellow
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SMILES
O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3)=NC=C2Br)C=CC=C1F)N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 100 mg/mL (104.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0452 mL | 5.2258 mL | 10.4516 mL | 26.1290 mL |
| 5 mM | 0.2090 mL | 1.0452 mL | 2.0903 mL | 5.2258 mL | |
| 10 mM | 0.1045 mL | 0.5226 mL | 1.0452 mL | 2.6129 mL | |
| 15 mM | 0.0697 mL | 0.3484 mL | 0.6968 mL | 1.7419 mL | |
| 20 mM | 0.0523 mL | 0.2613 mL | 0.5226 mL | 1.3065 mL | |
| 25 mM | 0.0418 mL | 0.2090 mL | 0.4181 mL | 1.0452 mL | |
| 30 mM | 0.0348 mL | 0.1742 mL | 0.3484 mL | 0.8710 mL | |
| 40 mM | 0.0261 mL | 0.1306 mL | 0.2613 mL | 0.6532 mL | |
| 50 mM | 0.0209 mL | 0.1045 mL | 0.2090 mL | 0.5226 mL | |
| 60 mM | 0.0174 mL | 0.0871 mL | 0.1742 mL | 0.4355 mL | |
| 80 mM | 0.0131 mL | 0.0653 mL | 0.1306 mL | 0.3266 mL | |
| 100 mM | 0.0105 mL | 0.0523 mL | 0.1045 mL | 0.2613 mL |
TMX-2138 Related Classifications
HY-164906 Related Classifications
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