TX-1918
TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM).
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- CAS No.: 503473-32-3
- 화학식: C14H12O3
- 분자량:228.24
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 44 μM (PKA), 44 μM (PKC), 4.4 μM (Src), 0.44 μM (eEF2 kinase)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
27.5 μM
Compound: 37; TX-1918
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Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTT assay
Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33650861] |
| HCC1937 | IC50 |
51.1 μM
Compound: 37; TX-1918
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Anticancer activity against human HCC1937 cells assessed as cell growth inhibition by MTT assay
Anticancer activity against human HCC1937 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33650861] |
| HCT-116 | EC50 |
230 μM
Compound: K00011, TX-1918
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Antitumor activity against human HCT116 cells
Antitumor activity against human HCT116 cells
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[PMID: 18077363] |
| HepG2 | EC50 |
2070 nM
Compound: K00011, TX-1918
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Antitumor activity against human HepG2 cells
Antitumor activity against human HepG2 cells
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[PMID: 18077363] |
Chemical Information
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CAS No. 503473-32-3
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분자량 228.24
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화학식 C14H12O3
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SMILES
O=C1/C(C(C=C1)=O)=C\C2=CC(C)=C(O)C(C)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Hori H, et al., TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. [Content Brief]
[2]. Zhang DW, et al., A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Res. 2019 Sep;169:104544. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TX-1918 Related Classifications
HY-112393 Related Classifications
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