7413 Results for "

isolated

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165

JC-1 Mitochondrial Membrane Potential Assay Kit

165 Publications Verification

Cat. No.: HY-K0601

MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

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Berberine sulfate

79 Cited Publications

Cat. No.: HY-N0716B

CAS No.: 633-66-9

Synonyms: Natural Yellow 18 sulfate

Category:

Alkaloids Ranunculaceae Coptis chinensis Franch. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

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Silvestrol

53 Cited Publications

Cat. No.: HY-13251

CAS No.: 697235-38-4

Purity: 99.96%

Synonyms: (-)-Silvestrol

Category:

Agave americana Linn. Natural Products Agavaceae Plants Disease Research Fields Cancer

Target:

Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .

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Berberine hemisulfate

53 Cited Publications

Cat. No.: HY-N0716A

CAS No.: 316-41-6

Synonyms: Natural Yellow 18 hemisulfate

Category:

Infection Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

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Astragaloside IV

42 Cited Publications

Cat. No.: HY-N0431

CAS No.: 84687-43-4

Category:

Triterpenes Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer

Target:

MMP ERK JNK

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

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Hesperidin

36 Cited Publications

Cat. No.: HY-15337

CAS No.: 520-26-3

Purity: 97.15%

Synonyms: Hesperetin 7-rutinoside

Category:

Flavonoids Anti-aging Flavonones Rutaceae Plants Endogenous metabolite Disease Research Fields Citrus Cancer

Target:

Apoptosis Autophagy Reactive Oxygen Species (ROS) Endogenous Metabolite

Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities .

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Artemisinin

34 Cited Publications

Cat. No.: HY-B0094

CAS No.: 63968-64-9

Synonyms: Qinghaosu; NSC 369397

Category:

Infection Piscidia erythrina L. Neurological Disease Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields

Target:

HCV Parasite Akt Ferroptosis

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

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Rocaglamide

32 Cited Publications

Cat. No.: HY-19356

CAS No.: 84573-16-0

Synonyms: Roc-A

Category:

Alkaloids Other Alkaloids Plants Disease Research Fields Meliaceae Aglaia elliptifolia Cancer

Target:

NF-κB HSP Eukaryotic Initiation Factor (eIF)

Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

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Oridonin

27 Cited Publications

Cat. No.: HY-N0004

CAS No.: 28957-04-2

Synonyms: NSC-250682; Isodonol

Category:

Infection Labiatae Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Butea monosperma Kuntze

Target:

Akt Bacterial Ligands for E3 Ligase

Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC₅₀s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

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Scutellarin

24 Cited Publications

Cat. No.: HY-N0751

CAS No.: 27740-01-8

Category:

Infection Flavonoids Flavones Labiatae Phenols Polyphenols Plants Disease Research Fields Medicago truncatula Gaertn.

Target:

STAT Akt HIV

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

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Calycosin

22 Cited Publications

Cat. No.: HY-N0519

CAS No.: 20575-57-9

Synonyms: Cyclosin

Category:

Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants other families Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Cancer Isoflavones

Target:

Apoptosis

Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer .

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Echinacoside

21 Cited Publications

Cat. No.: HY-N0020

CAS No.: 82854-37-3

Category:

Simple Phenylpropanols Cistanche deserticola Ma Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants

Target:

Wnt Reactive Oxygen Species (ROS)

Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

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Evodiamine

19 Cited Publications

Cat. No.: HY-N0114

CAS No.: 518-17-2

Synonyms: (+)-Evodiamine; d-Evodiamine

Category:

Alkaloids Piperidine Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Cancer Indole Alkaloids

Target:

Others

Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.

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Baohuoside I

18 Cited Publications

Cat. No.: HY-N0011

CAS No.: 113558-15-9

Synonyms: Icariin-II; Icariside-II

Category:

Flavonols Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Epimedium koreanum Nakai Phenols Polyphenols Berberidaceae Disease Research Fields Inflammation/Immunology Endocrinology Cancer

Target:

CXCR Apoptosis

Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.

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Piperine

18 Cited Publications

Cat. No.: HY-N0144

CAS No.: 94-62-2

Synonyms: Bioperine; 1-Piperoylpiperidine

Category:

Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite Autophagy P-glycoprotein

Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

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YM-254890

18 Cited Publications

Cat. No.: HY-111557

CAS No.: 568580-02-9

Purity: ≥95.0%

Category:

Cardiovascular Disease Natural Products Microorganisms Disease Research Fields

Target:

P2Y Receptor

YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y₁ signal transduction pathway, with an IC₅₀ value below 0.6 μM .

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Crocin

17 Cited Publications

Cat. No.: HY-N0697

CAS No.: 42553-65-1

Synonyms: Crocin I

Category:

Neurological Disease Anti-aging Lridaceae Plants Crocus sativus L. Functional Molecules Terpenoids Research of Health Products Diterpenoids Disease Research Fields Inflammation/Immunology Cancer

Target:

Endogenous Metabolite JAK Apoptosis

Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities .

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Allicin

17 Cited Publications

Cat. No.: HY-N0315

CAS No.: 539-86-6

Synonyms: Diallyl thiosulfinate

Category:

Infection Natural Products Liliaceae Plants Disease Research Fields A．Sativam L. var．Viviparum Regel

Target:

Bacterial Antibiotic

Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .

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Punicalagin

17 Cited Publications

Cat. No.: HY-N0063

CAS No.: 65995-63-3

Category:

Infection Punica granatum L. Metabolic Disease Phenols Polyphenols Punicaceae Plants Disease Research Fields

Target:

SARS-CoV HBV

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL ^pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .

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Liquiritin

17 Cited Publications

Cat. No.: HY-N0376

CAS No.: 551-15-5

Category:

Neurological Disease Plants Flavonoids Monophenols Leguminosae Flavonones Phenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

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