CST651
CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC50 values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia.
(Pink: Cdk4/cyclin D3 and Cdk4/cyclin D1 and Cdk6/cyclin D2 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440)).
For research use only. We do not sell to patients.
- CAS No.: 2489241-16-7
- Formula: C56H72FN11O9S
- Molecular Weight:1094.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
More
Biological Activity
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CDK6 5.1 nM (DC50, In MM.1S cells) |
CDK4 20 nM (DC50, In MM.1S cells) |
VHL |
Chemical Information
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CAS No. 2489241-16-7
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Molecular Weight 1094.30
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Formula C56H72FN11O9S
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SMILES
O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCN(CCOCCOCCOC6=CC(C7=C(C)N=CS7)=CC=C6CNC([C@H]8N(C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)C[C@H](O)C8)=O)CC5)C=N4)C
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Synonyms
PROTAC CDK4/6 degrader 34
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CST651 Related Classifications
HY-134303 Related Classifications
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