Art. -Nr.: HY-18739

Biologically Validated

Phorbol 12-myristate 13-acetate

Name: Phorbol 12-myristate 13-acetate
Brand: MedChemExpress
SKU: HY-18739
Price: 60.00 USD
Availability: InStock
Rating: 5 (863 reviews)

(Synonyms: PMA; TPA; Phorbol myristate acetate)

863 Cited Publications

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Based on 863 publication(s) in Google Scholar

Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress).

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Reinheit : 99.80%
CAS. Nr.: 16561-29-8
Formel: C₃₆H₅₆O₈
Molecular Weight:616.83

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Phorbol 12-myristate 13-acetate Chemical Structure

CAS. Nr.: 16561-29-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- MCE Validation Data
- Cellular Effect
- In Vitro
- Induced Disease Models
Chemical Information
Publications (863)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll (1)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator^[1]^[2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress)^[3]^[7].

IC₅₀ & Target

^[1]^[7]

PKC

11.7 nM (EC₅₀)

NF-κB

Alle PKC Isoform-spezifische Produkte anzeigen :

Alle SphK Isoform-spezifische Produkte anzeigen :

SphK1
SphK2

Alle NF-κB Isoform-spezifische Produkte anzeigen :

MCE Validation Data

THP-1 cells were seeded at 2 × 10⁵ cells/well in a 24 well plate and treated with 100 and 200 ng/mL Phorbol 12-myristate 13-acetate (PMA) (HY-18739) for 24 or 48 h. The results indicated that PMA induces THP-1 cell differentiation.
THP-1 cells were seeded at 2 × 10⁵ cells/well in a 24 well plate and treated with 100 and 200 ng/mL Phorbol 12-myristate 13-acetate (PMA) (HY-18739) for 24 h. Cells were lysed and the expression of CD11b was measured. The results indicated that PMA increases expression of CD11b.
THP-1 cells were seeded at 3 × 10⁵ cells/well in a 12 well plate and treated with 100 and 200 ng/mL Phorbol 12-myristate 13-acetate (PMA) (HY-18739) for 24 h. The results indicated that PMA induces THP-1 cell differentiation and showed lot-to-lot consistency.

Cellular Effect

Cell Line	Type	Value	Description	References
K562	GI₅₀	0.00012 μg/mL Compound: 7	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18163590]
K562	GI₅₀	0.12 ng/mL Compound: 7	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 18163590]
MT4	EC₅₀	0.7 nM Compound: 13	Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay Antiviral activity against HIV2 ROD infected in MT4 cells assessed as cell viability after 5 days by MTT assay	[PMID: 25970561]
MT4	EC₅₀	0.9 nM Compound: 13	Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay Antiviral activity against HIV1 3B infected in MT4 cells assessed as cell viability after 5 days by MTT assay	[PMID: 25970561]
NIH3T3	GI₅₀	0.01 μg/mL Compound: 7	Cytotoxicity against BALB/c mouse 3T3 cells Cytotoxicity against BALB/c mouse 3T3 cells	[PMID: 18163590]
SNU-387	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay	[PMID: 23701597]
U-937	EC₅₀	0.45 nM Compound: PMA	Induction of attachment of U937 cells after 48 hrs Induction of attachment of U937 cells after 48 hrs	[PMID: 17284021]
Vero	CC₅₀	5.7 μM Compound: 4, TPA	Cytotoxicity against african green monkey Vero cells by MTS assay Cytotoxicity against african green monkey Vero cells by MTS assay	[PMID: 23215460]
Vero	EC₅₀	>162 μM Compound: 4, TPA	Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Semliki forest virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	0.0029 μM Compound: 4, TPA	Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Chikungunya virus 899 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	2.2 μM Compound: 4, TPA	Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay Antiviral activity against Sindbis virus HRsp infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect incubated for 6 to 7 days by MTS assay	[PMID: 23215460]
Vero	EC₅₀	2.9 nM Compound: 13	Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days Antiviral activity against chikungunya virus Indian ocean strain 899 infected in Vero cells assessed as virus-induced cytopathic effect after 6 to 7 days	[PMID: 25970561]
Vero	CC₅₀	5.7 μM Compound: TPA	Cytotoxicity against African green monkey Vero cells assessed as morphological changes by microscopic method Cytotoxicity against African green monkey Vero cells assessed as morphological changes by microscopic method	[PMID: 28925702]

In Vitro

PMA (100, 200 ng/mL; 1-5 days) induce THP-1 cells to differentiate into macrophage-like cells (THP-1 macrophages), characterized by changes in morphology (adherent macrophage-like phenotype), and increases cell surface expression of CD11b^[3]^[5].
PMA (20 ng/mL, 36 h) inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Phorbol 12-myristate 13-acetate (PMA) can be used to create models of ear edema^[8]^[9].

1. Induction of Preventable Oedema at Ear^[8]

Background

PMA induces a pronounced inflammatory response mediated by protein kinase C (PKC), specifically activating PLA2 to trigger inflammation.

Specific Modeling Methods

Mice: Swiss mouse • Female • 25-30 g
Administration: Topically applied in one ear • 100 μg/mL in 20 μL (2 μg/ear) vehicle • single dose

Note

Inhibitory or reventable compounds' administration should be performed before modeling. Such as Hydroxyachillin, should be administered 1 h before PMA treatment.

Modeling Indicators

Appearance monitoring: The thickness difference between the left and right ears increases significantly.
Indicator changes: Increased vascular permeability.

Opposite Product(s): Hydroxyachillin; Indomethacin (HY-14397)

2. Induction of Suppressible Oedema at Ear^[9]

Background

PMA induces a pronounced inflammatory response mediated by protein kinase C (PKC), specifically activating PLA2 to trigger inflammation.

Specific Modeling Methods

Rat: Wistar • male • adult with weight of 200-220 g
Mice: Swiss albino • male • 25-30 g
Administration: Topically applied in one ear • 2.5 μg in 20 μL vehicle • single dose

Note

Inhibitory compounds' administration should be conducted 4 h before mouse were killed.

Modeling Indicators

Appearance monitoring: The quality difference between the left and right ears increases significantly.
Indicator changes: Stimulate macrophages to produce superoxide anions.

Correlated Product(s): Carrageenan (HY-125474); Histamine (HY-B1204); Serotonin (HY-B1473A); Prostaglandin E2 (PGE2) (HY-101952)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 16561-29-8
Appearance Solid
Molecular Weight 616.83
Formel C₃₆H₅₆O₈
Color White to off-white
SMILES

CCCCCCCCCCCCCC(O[C@H]([C@H]1C)[C@]2(OC(C)=O)[C@@]([C@@](C=C(CO)C[C@]34O)([H])[C@@]1(O)[C@]4([H])C=C(C)C3=O)([H])C2(C)C)=O
Synonyms

PMA; TPA; Phorbol myristate acetate
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (863)

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Adv Sci (Weinh)

Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression. [Abstract]

2025 Jan;12(2):e2406865. PMID: 39535362
Adv Sci (Weinh)

ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis-Associated Hepatocellular Carcinoma by Modulating Tumor-Associated Macrophages. [Abstract]

2024 Dec;11(45):e2404756. PMID: 39377228
Adv Sci (Weinh)

A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia-Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis. [Abstract]

2024 Dec;11(45):e2404571. PMID: 39258712
Adv Sci (Weinh)

The Thyroid Hormone Analog GC-1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization. [Abstract]

2024 Nov;11(44):e2401931. PMID: 39373388
Adv Sci (Weinh)

Mitochondria-Targeted Nanoadjuvants Induced Multi-Functional Immune-Microenvironment Remodeling to Sensitize Tumor Radio-Immunotherapy. [Abstract]

2024 Jul;11(26):e2400297. PMID: 38704675
Adv Sci (Weinh)

Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. [Abstract]

2024 May;11(19):e2306378. PMID: 38482749
MedComm

Transcription factor EHF drives cholangiocarcinoma development through transcriptional activation of glioma-associated oncogene homolog 1 and chemokine CCL2. [Abstract]

2024 May 13;5(5):e535. PMID: 38741887
MedComm

M1 macrophage-derived exosomes promote autoimmune liver injury by transferring long noncoding RNA H19 to hepatocytes. [Abstract]

2023 Jun 29;4(4):e303. PMID: 37398637
Adv Sci (Weinh)

Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis. [Abstract]

2022 Jan;9(3):e2102435. PMID: 34825505
Cell Rep Med

Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]

2026 Jun 16;7(6):102833. PMID: 42173096
Cell Rep Med

HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion. [Abstract]

2026 Apr 21;7(4):102691. PMID: 41861828
Cell Rep Med

Macrophage efferocytosis mediated by the TP63-RAC2 pathway promotes immunosuppressive remodeling in esophageal cancer. [Abstract]

2025 Dec 18:102529. PMID: 41418775
Cell Rep Med

Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity. [Abstract]

2025 Apr 15;6(4):102079. PMID: 40199328
Sci Adv

Genome-wide CRISPR screen identifies IRF1 and TFAP4 as transcriptional regulators of Galectin-9 in T cell acute lymphoblastic leukemia. [Abstract]

2025 Mar 21;11(12):eads8351. PMID: 40106574
Biomaterials

Ultrasound-responsive renal-targeted nanoparticles deliver TAK-242 to inhibit NF-κB/NLRP3 signaling and attenuate sepsis-associated acute kidney injury. [Abstract]

2026 Jun:329:123922. PMID: 41481962
Biomaterials

Self-adaptive covalent coating for vascular stents: Coordinated coagulation-inflammation regulation to support re-endothelialization for atherosclerosis control. [Abstract]

2026 Feb:325:123600. PMID: 40753783
Cell Death Differ

Targeting MMA-induced USP36 methylmalonylation to suppress macrophage polarization and tumor progression in clear-cell renal cell carcinoma. [Abstract]

2025 Dec 15. PMID: 41398045
Biomaterials

pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time. [Abstract]

2018 Jul:170:70-81. PMID: 29653288
Med

MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors. [Abstract]

2026 Jan 9;7(1):100936. PMID: 41308654
Neuro Oncol

Low level of tumor necrosis factor α in tumor microenvironment maintains self-renewal of glioma stem cells by Vasorin-mediated glycolysis. [Abstract]

2024 Dec 5;26(12):2256-2271. PMID: 39093693
Neuro Oncol

A disintegrin and metalloproteinase 22 activates integrin β1 through its disintegrin domain to promote the progression of pituitary adenoma. [Abstract]

2024 Jan 5;26(1):137-152. PMID: 37555799

Phorbol 12-myristate 13-acetate purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2024 Jan 5;26(1):137-152. [Abstract]

Western Blot (WB) analysis ofADAM22 expression in indicated cells after PMA (150 nM) or forskolin (50 μM) administration for 0 hour, 24 hours, 48 hours, and 72 hours.
Research (Wash D C)

NIR-Activated ICG-Loaded M2 Macrophage Exosomes Ameliorate Periodontitis via Targeting Infection Inflammation and Oxidative Stress. [Abstract]

2026 Apr 27:9:1207. PMID: 42051363
Research (Wash D C)

Repurposed Acarbose Targets Nidogen-1 to Remodel the Tumor Stroma and Suppress Portal Vein Tumor Thrombus in Hepatocellular Carcinoma. [Abstract]

2026 Feb 25:9:1161. PMID: 41756725
Research (Wash D C)

Microfluidic Perfusable Pathological Vasculature for Atherosclerosis Drug Screening. [Abstract]

2025 Sep 19:8:0902. PMID: 40979559
Research (Wash D C)

Astrocyte-Derived Interleukin 11 Modulates Astrocyte-Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy. [Abstract]

2025 Jan 30:8:0598. PMID: 39886603
Chem Eng J

2025 Dec 10;527:171773.
Chem Eng J

2025 Jul 1.
J Control Release

Biomimetic trident lipid anchoring enables stable neutrophil-based combination therapy. [Abstract]

2026 Jun 10:394:114903. PMID: 41942056
J Control Release

Fibrin gel-based co-delivery of self-adjuvant tumor vaccine and PD-1 blockade for post-surgical gastric cancer immunotherapy. [Abstract]

2026 Mar 10:391:114629. PMID: 41544668
Cancer Biol Med

Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway. [Abstract]

2025 Oct 23:j.issn.2095-3941.2024.0241. PMID: 41131865
J Control Release

Archaea-inspired deoxyribonuclease I liposomes prevent multiple organ dysfunction in sepsis. [Abstract]

2025 Apr 10:380:1109-1126. PMID: 39986474
J Control Release

TRAIL-expressing cell membrane nanovesicles as an anti-inflammatory platform for rheumatoid arthritis therapy. [Abstract]

2020 Apr 10:320:304-313. PMID: 32004586
Cell Death Dis

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer. [Abstract]

2026 Jun 23. PMID: 42336814
Cell Death Dis

MTFR2 promotes VDAC1 oligomerization to reprogram BCAA metabolism in tumor cells to polarize TAMs in LUAD. [Abstract]

2026 May 20. PMID: 42161922
Cell Death Dis

The RASSF1C-HIF-1α axis drives macrophage lipid metabolism to promote pancreatic cancer. [Abstract]

2026 Mar 30;17(1):430. PMID: 41912489
Cell Death Dis

Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance. [Abstract]

2025 Dec 19. PMID: 41419454
Cell Death Dis

Targeting TIMM23 to overcome osteosarcoma chemoresistance. [Abstract]

2025 Nov 24;16(1):856. PMID: 41285805
Cell Death Dis

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization. [Abstract]

2025 May 14;16(1):379. PMID: 40368902
Cell Death Dis

FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas. [Abstract]

2025 Apr 15;16(1):301. PMID: 40234389
Cell Death Dis

Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via m6A modification of CSF1. [Abstract]

2025 Apr 26;16(1):345. PMID: 40287444
Pharmacol Res

Antagonising Yin Yang 1 ameliorates the symptoms of lupus nephritis via modulating T lymphocyte signaling. [Abstract]

2024 Dec:210:107525. PMID: 39613121
Environ Sci Technol

Intracellular Protein Adsorption Behavior and Biological Effects of Polystyrene Nanoplastics in THP-1 Cells. [Abstract]

2024 Feb 13;58(6):2652-2661. PMID: 38294362
Cell Mol Biol Lett

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis. [Abstract]

2024 Jan 3;29(1):8. PMID: 38172700
Environ Sci Technol

Triclosan Reprograms Immunometabolism and Activates the Inflammasome in Human Macrophages. [Abstract]

2023 Jan 10;57(1):428-439. PMID: 36546883
Pharmacol Res

SHH/GLI2-TGF-β1 feedback loop between cancer cells and tumor-associated macrophages maintains epithelial-mesenchymal transition and endoplasmic reticulum homeostasis in cholangiocarcinoma. [Abstract]

2023 Jan:187:106564. PMID: 36423790
Pharmacol Res

Systematic pan-cancer analysis identifies APOC1 as an immunological biomarker which regulates macrophage polarization and promotes tumor metastasis. [Abstract]

2022 Sep:183:106376. PMID: 35914680
Cell Death Dis

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway. [Abstract]

2022 Feb 24;13(2):183. PMID: 35210436
Cell Death Dis

Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer. [Abstract]

2021 Aug 30;12(9):818. PMID: 34462422
Cell Death Dis

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway. [Abstract]

2021 May 25;12(6):533. PMID: 34031369
Cell Death Dis

Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1. [Abstract]

2020 Jan 30;11(1):78. PMID: 32001671
Pharmacol Res

Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway. [Abstract]

2019 Apr:142:1-13. PMID: 30735802

Phorbol 12-myristate 13-acetate purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2019 Apr:142:1-13. [Abstract]

Total lysates from cells are analyzed for the expression of MMP-2 and MMP-9 by Western blot analysis in the treatment of different concentrations of PMA and PDD.

Phorbol 12-myristate 13-acetate purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2019 Apr:142:1-13. [Abstract]

MDA-MB-231 cells are pretreated with PPD for 24 h followed by exposure to 50 ng/mL of PMA for 30 min. The whole cell lysates are analyzed by Western blot for the activation of MAPK.
Cell Death Dis

CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling. [Abstract]

2018 Aug 29;9(9):880. PMID: 30158589
Cancer Lett

Targeting C/EBPβ/SCD1/C16:1 loop-driven macrophage M2 polarization by Bruceine D improves anti-PD-1 immunotherapy in colorectal cancer. [Abstract]

2026 Sep 28:656:218655. PMID: 42250753
Cancer Lett

Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition. [Abstract]

2026 May 28:646:218425. PMID: 41819525
Cancer Lett

Neutrophil extracellular traps enhance platinum resistance in ovarian cancer via SHP-1 activation. [Abstract]

2026 Apr 10:643:218288. PMID: 41620200
Cancer Lett

HOXC8-activated TRIM22/NF-κB pathway promotes stemness in colorectal cancer. [Abstract]

2026 Jan 28:638:218156. PMID: 41265630
Cancer Lett

Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages. [Abstract]

2025 Sep 1:627:217544. PMID: 39929434
Cancer Lett

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. [Abstract]

2024 Apr 10:587:216732. PMID: 38360142
Cancer Lett

Delivery of CD47-SIRPα checkpoint blocker by BCMA-directed UCAR-T cells enhances antitumor efficacy in multiple myeloma. [Abstract]

2024 Mar 31:585:216660. PMID: 38266806
Cancer Lett

LW-213 induces immunogenic tumor cell death via ER stress mediated by lysosomal TRPML1. [Abstract]

2023 Nov 28:577:216435. PMID: 37806516
J Immunother Cancer

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion. [Abstract]

2025 Nov 28;13(11):e011976. PMID: 41314980
J Immunother Cancer

Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma. [Abstract]

2025 Aug 22;13(8):e011091. PMID: 40846326
J Immunother Cancer

Integrated system for screening tumor-specific TCRs, epitopes, and HLA subtypes using single-cell sequencing data. [Abstract]

2025 Jul 31;13(7):e012029. PMID: 40744664
Int J Biol Sci

Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation. [Abstract]

2025 Apr 22;21(7):3061-3080. PMID: 40384874
J Immunother Cancer

Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma. [Abstract]

2025 Jan 4;13(1):e010183. PMID: 39755578
Int J Biol Sci

Senescent renal tubular cells derived extracellular vesicles transported miR-20a and miR-21 induced macrophage-to-myofibroblast transition in renal fibrosis after ischemia reperfusion injury. [Abstract]

2025 Jan 6;21(3):940-954. PMID: 39897045
J Immunother Cancer

Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway. [Abstract]

2024 Sep 4;12(9):e009318. PMID: 39237260
Int J Biol Sci

SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis. [Abstract]

2024 Jan 12;20(3):968-986. PMID: 38250161
Int J Biol Sci

Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. [Abstract]

2020 Jun 27;16(13):2382-2391. PMID: 32760206
Cell Commun Signal

Intestinal epithelial PIEZO1 regulates macrophage-to-myofibroblast transition via epithelial-derived TGF-α signaling in Crohn's disease. [Abstract]

2026 May 28. PMID: 42210253
Cell Commun Signal

NSP1 of Alongshan virus antagonizes type I interferon responses by promoting STUB1-mediated degradation of RIG-I. [Abstract]

2026 Mar 24;24(1):262. PMID: 41877189
Cell Commun Signal

NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment. [Abstract]

2025 Jul 21;23(1):348. PMID: 40691620
Cell Commun Signal

Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis. [Abstract]

2025 Jan 6;23(1):6. PMID: 39762835
Cell Commun Signal

Neutrophil extracellular traps promote angiogenesis in gastric cancer. [Abstract]

2023 Jul 21;21(1):176. PMID: 37480055
Cell Commun Signal

Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth. [Abstract]

2023 May 1;21(1):86. PMID: 37127629
J Exp Med

EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model. [Abstract]

2022 May 2;219(5):e20212414. PMID: 35420633
J Neuroinflammation

CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations. [Abstract]

2026 Jul 8. PMID: 42421023
J Neuroinflammation

Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways. [Abstract]

2022 Jul 28;19(1):194. PMID: 35902863
Phytomedicine

2026 Oct:160:158655. PMID: 42542054
Phytomedicine

Shegan Mahuang Decoction ameliorates pulmonary fibrosis progression by inhibiting CCL3-mediated NETosis. [Abstract]

2026 Aug:158:158386. PMID: 42275874
Phytomedicine

Oxymatrine attenuates melanoma progression and metastasis through SORBS2-mediated suppression of M2 macrophage polarization. [Abstract]

2026 Jun:155:158148. PMID: 41956023
Phytomedicine

Wuse-oil Compound 03 mitigates radiation-induced oral mucositis by modulating oral microbiota to mediate TLR4/NF-κB pathway and inhibit M1 macrophage polarization. [Abstract]

2025 Sep:145:157083. PMID: 40714424
Phytomedicine

Calycosin inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by downregulating early growth response 1. [Abstract]

2025 Jul 25:143:156884. PMID: 40446581
Phytomedicine

Tetrahydrocurcumin alleviates colorectal tumorigenesis by modulating the SPP1/CD44 axis and preventing M2 tumor-associated macrophage polarization. [Abstract]

2025 Jun:141:156674. PMID: 40220425
Phytomedicine

Panax notoginseng saponins ameliorate LPS-induced acute lung injury by promoting STAT6-mediated M2-like macrophage polarization. [Abstract]

2025 Apr:139:156513. PMID: 40010033
Phytomedicine

Protopine ameliorates OVA-induced asthma through modulatingTLR4/MyD88/NF-κB pathway and NLRP3 inflammasome-mediated pyroptosis. [Abstract]

2024 Apr:126:155410. PMID: 38367422
Phytomedicine

Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys. [Abstract]

2024 Apr:126:155450. PMID: 38368794
Phytomedicine

Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota. [Abstract]

2022 Nov:106:154416. PMID: 36037770
Phytomedicine

Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro. [Abstract]

2021 Jun:86:153562. PMID: 33857849
J Pharm Anal

2026 Apr 2.
EBioMedicine

Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes. [Abstract]

2023 Jan:87:104410. PMID: 36525723
Mater Today Bio

Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants. [Abstract]

2026 Apr 30. PMID: 42182868
Adv Healthc Mater

Biomimetic Copper-Doped Nano-Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia. [Abstract]

2026 Mar 10:e04039. PMID: 41804653
Mater Today Bio

Mitochondrial biogenesis modulation by silicon-stimulated mesenchymal stem cells-derived extracellular vesicles drives angio- and lymphangiogenesis in chronic wound healing. [Abstract]

2025 Dec 3:35:102629. PMID: 41450334
Cancer Genet

FBXL16 regulates TAMs recruitment by mediating cytokine release in gliomas. [Abstract]

2025 Nov:298-299:285-294. PMID: 41265012
Mater Today Bio

2025 Sep 6;35:102286.
Adv Healthc Mater

MOF-818 Nanozyme Suppresses Calcium Oxalate Kidney Stones by Alleviating Oxidative Stress and Inflammatory Injury. [Abstract]

2025 Mar;14(8):e2401574. PMID: 39171497
Nano Today

2024 Dec.
J Hazard Mater

Silicon carbide nanoparticles induce pulmonary fibrosis by promoting macrophage apoptosis through parkin-mediated mitophagy disruption and the intervention effect of emodin. [Abstract]

2026 Apr 1:507:141765. PMID: 41864028
Cell Death Discov

2026 Jul 7. PMID: 42414266
Mol Psychiatry

Role of LXRβ in oligodendrocytes in neuronal survival. [Abstract]

2025 Oct 1. PMID: 41034505
Acta Pharmacol Sin

Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth. [Abstract]

2025 May 20. PMID: 40394236
Cell Death Discov

NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury. [Abstract]

2025 Feb 20;11(1):69. PMID: 39979243
Cell Death Discov

Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis. [Abstract]

2024 Nov 3;10(1):463. PMID: 39489776
Cell Death Discov

Nuclear PCGF3 inhibits the antiviral immune response by suppressing the interferon-stimulated gene. [Abstract]

2024 Oct 5;10(1):429. PMID: 39368978
Cell Death Discov

Neutrophil extracellular traps promote invasion and metastasis via NLRP3-mediated oral squamous cell carcinoma pyroptosis inhibition. [Abstract]

2024 May 2;10(1):214. PMID: 38697992
Acta Pharmacol Sin

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism. [Abstract]

2023 May;44(5):940-953. PMID: 36357669
Cell Death Discov

Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis. [Abstract]

2023 Jan 23;9(1):26. PMID: 36690641
Acta Pharmacol Sin

Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays. [Abstract]

2022 Sep;43(9):2429-2438. PMID: 35110698
Cell Death Discov

Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. [Abstract]

2022 Feb 2;8(1):43. PMID: 35110526
Acta Biomater

Porous Se@SiO2 nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-κB pathway inhibition. [Abstract]

2019 Apr 1:88:392-405. PMID: 30753941
J Orthop Translat

2026 Jul 2:59:101168. PMID: 42437282
J Transl Med

Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression. [Abstract]

2025 Aug 21;23(1):950. PMID: 40841904

Phorbol 12-myristate 13-acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Aug 21;23(1):950. [Abstract]

The migratory and invasive capabilities of HOS and MG-63 cells were assessed using Transwell assays in response to normoxic or hypoxic M0, M1, and M2 macrophages. THP-1 cells underwent differentiation into M0 macrophages following 24 h exposure to 100 ng/mL phorbol 12-myristate 13-acetate (PMA, HY-18739). Following a 24 h recovery in a fresh complete medium, cells were treated with 100 ng/mL lipopolysaccharide and 20 ng/mL IFN-gamma Protein, Human (IFN-γ, HY-P7025A) for 48 h to drive M1 polarization.
J Transl Med

Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression. [Abstract]

2025 Aug 18;23(1):923. PMID: 40826409
J Transl Med

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma. [Abstract]

2025 Jan 22;23(1):103. PMID: 39844299
J Transl Med

Napabucasin-loaded PLGA nanoparticles trigger anti-HCC immune responses by metabolic reprogramming of tumor-associated macrophages. [Abstract]

2024 Dec 20;22(1):1125. PMID: 39707412
J Transl Med

tRNA-derived fragment 3'tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer. [Abstract]

2024 Jul 30;22(1):706. PMID: 39080676
J Transl Med

P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin. [Abstract]

2023 May 9;21(1):314. PMID: 37161570
Sci China Life Sci

N6-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail. [Abstract]

2025 Aug 21. PMID: 40856928
Proc Natl Acad Sci U S A

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1. [Abstract]

2022 Feb 22;119(8):e2114851119. PMID: 35181605
Nano Res

2021 Mar 27.
Diabetes

N 6-Methyladenosine demethylase FTO controls macrophage homeostasis in diabetic vasculopathy. [Abstract]

2025 Jan 1;74(1):82-95. PMID: 39446524
Dev Cell

Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity. [Abstract]

2026 Apr 29:S1534-5807(26)00150-4. PMID: 42061405
Dev Cell

STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma. [Abstract]

2025 Jun 23;60(12):1751-1767.e9. PMID: 39933531
Basic Res Cardiol

HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype. [Abstract]

2021 Apr 23;116(1):30. PMID: 33893593
Oncogene

Enhancing glioma immunotherapy by disrupting RBP-J-mediated NNMT signaling in tumor microenvironment. [Abstract]

2026 Aug;45(29):2959-2977. PMID: 42310095
BME Front

mPEG@ELA-11 Alleviates Atherosclerosis via AKT-ER Stress-Mediated Macrophage Modulation. [Abstract]

2025 Nov 25:6:0203. PMID: 41306397
Oncogene

IL-17RA/CTSK axis mediates H. pylori-induced castration-resistant prostate cancer growth. [Abstract]

2024 Nov;43(49):3598-3616. PMID: 39424989
Apoptosis

BMP7 attenuates myocardial injury and preserves cardiac function after myocardial infarction by inhibiting cardiomyocyte pyroptosis. [Abstract]

2026 Jan 23;31(2):57. PMID: 41575474
Apoptosis

Deciphering macrophage heterogeneity and factors driving M2 polarization in lung adenocarcinoma through single-cell RNA sequencing. [Abstract]

2025 Oct 16. PMID: 41099999
Apoptosis

Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8+ T cell dysfunction and suppress cervical cancer progression. [Abstract]

2024 Dec;29(11-12):2108-2127. PMID: 39404933
Apoptosis

Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation. [Abstract]

2024 Oct;29(9-10):1810-1823. PMID: 38704789
Alzheimers Res Ther

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing. [Abstract]

2022 Jul 26;14(1):103. PMID: 35883144
Food Res Int

2026 Feb 11.
Leukemia

Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. [Abstract]

2025 Aug;39(8):1997-2009. PMID: 40588566
Leukemia

Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling. [Abstract]

2023 Mar;37(3):560-570. PMID: 36550214
Int J Biol Macromol

Omentin-1 promotes diabetic wound healing by regulating macrophage efferocytosis and M2 polarization. [Abstract]

2026 Feb:347:150757. PMID: 41654047
Int J Biol Macromol

A high-throughput reporter assay for screening potential gasdermin D inhibitors from natural products. [Abstract]

2026 Jan;339(Pt 2):150110. PMID: 41500275
Int J Biol Macromol

Downregulation of the biological macromolecule Spondin-2 disrupts maternal-fetal immune tolerance and trophoblast invasion, driving unexplained recurrent pregnancy loss. [Abstract]

2025 Dec 12;338(Pt 1):149672. PMID: 41391791
Int J Biol Macromol

Exploiting an evolutionary constraint: Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection. [Abstract]

2025 Jul 29;321(Pt 3):146394. PMID: 40744178
J Headache Pain

Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4. [Abstract]

2025 May 15;26(1):116. PMID: 40375206
Int J Biol Macromol

Bletilla striata polysaccharides alleviate ARDS by inhibiting NETs-induced pyroptosis in pulmonary alveolar macrophage through the PAD4 pathway. [Abstract]

2025 May;305(Pt 1):141026. PMID: 39954881
Int J Nanomedicine

Electromechanical Regulation Underlying Protein Nanoparticle-Induced Osmotic Pressure in Neurotoxic Edema. [Abstract]

2025 Apr 5:20:4145-4163. PMID: 40207308
BMC Med

Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations. [Abstract]

2025 Mar 31;23(1):189. PMID: 40165248
Int J Biol Macromol

S100A9 promotes renal calcium oxalate stone formation via activating the TLR4-p38/MAPK-LCN2 signaling pathway. [Abstract]

2024 Nov;281(Pt 1):136178. PMID: 39357728
Int J Biol Macromol

Ultra-small platinum nano-enzymatic spray with ROS scavenging and anti-inflammatory properties for photoaging treatment. [Abstract]

2024 Nov;280(Pt 2):135743. PMID: 39304038
Int J Biol Macromol

Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L. [Abstract]

2024 Mar;260(Pt 1):129455. PMID: 38232876
Int J Biol Macromol

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease. [Abstract]

2023 Jul 31:244:125373. PMID: 37327932
Int J Mol Med

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells. [Abstract]

2026 Jun;57(6):158. PMID: 41992969
Int J Mol Med

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling. [Abstract]

2026 Apr;57(4):85. PMID: 41645764
Int J Mol Med

Platelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling. [Abstract]

2025 May;55(5):78. PMID: 40084691
Microbiol Res

Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis. [Abstract]

2024 Dec:289:127927. PMID: 39393129
Neural Regen Res

Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype. [Abstract]

2024 Nov 1;19(11):2488-2498. PMID: 38526285
NPJ Breast Cancer

NR4A3 potentials M1-like macrophage polarization to facilitate anti-tumor immune responses in breast cancer. [Abstract]

2025 Jul 7;11(1):67. PMID: 40624019
JACC Basic Transl Sci

ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis. [Abstract]

2024 Oct 9;9(12):1388-1405. PMID: 39822602
EMBO J

Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection. [Abstract]

2023 Dec 1;42(23):e114086. PMID: 37807855
J Clin Periodontol

Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages. [Abstract]

2025 Aug;52(8):1196-1210. PMID: 40388972
J Clin Periodontol

Dynamin-Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1. [Abstract]

2025 Apr;52(4):622-636. PMID: 39762202
Mol Med

Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases. [Abstract]

2024 Dec 19;30(1):245. PMID: 39701924
Mol Med

Th1 cells reduce the osteoblast-like phenotype in valvular interstitial cells by inhibiting NLRP3 inflammasome activation in macrophages. [Abstract]

2024 Jul 30;30(1):110. PMID: 39080527
Antioxidants (Basel)

2026 Jul 30;15(8):955. PMID: 42650219
Mater Des

2026 Jun 3;267:116298.
Antioxidants (Basel)

Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor Cytotoxicity. [Abstract]

2026 Mar 25;15(4):413. PMID: 42072056
Cell Mol Gastroenterol Hepatol

Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization Via the Suppression of the NF-κB Signaling Pathway. [Abstract]

2025;19(10):101558. PMID: 40562095
Phytother Res

20(R)-Ginsenoside Rg3 Suppresses P-Glycoprotein-Mediated Multidrug Resistance in A549/Taxol Cells by Targeting MDM2-IκB-α Signaling Axis. [Abstract]

2026 Apr;40(4):1935-1950. PMID: 41630373
Phytother Res

Ginsenoside Re inhibits non-small cell lung cancer progression by suppressing macrophage M2 polarization induced by AMPKα1/STING positive feedback loop. [Abstract]

2024 Nov;38(11):5088-5106. PMID: 39119862
Phytother Res

Atractylenolide-III alleviates osteoarthritis and chondrocyte senescence by targeting NF-κB signaling. [Abstract]

2023 Oct;37(10):4607-4620. PMID: 37380363
Phytother Res

20(S)- Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis. [Abstract]

2023 Oct;37(10):4690-4705. PMID: 37424151
Free Radic Biol Med

Fyn deficiency drives pro-inflammatory macrophage activation to exacerbate septic acute lung injury. [Abstract]

2026 Mar 16:246:80-92. PMID: 41490764
Free Radic Biol Med

PN-CeO2 as a potential therapeutic agent for atopic dermatitis: Antioxidant and anti-inflammatory effects. [Abstract]

2025 Nov:239:540-551. PMID: 40782974
Free Radic Biol Med

Sophoridine alleviates sepsis-associated encephalopathy by inhibiting MARK4 and NLRP3 signaling. [Abstract]

2025 Oct 28:S0891-5849(25)01324-3. PMID: 41167535
Free Radic Biol Med

Fat mass and obesity-associated protein inhibits macrophage-mediated inflammation via the m6A demethylation of c-Jun in COPD. [Abstract]

2025 Sep 12:241:14-23. PMID: 40945342
Free Radic Biol Med

FUNDC1-dependent mitochondrial-ER membranes mediate mitochondrial dysfunction and melanocyte damage under oxidative stress. [Abstract]

2025 Aug 15:240:108-123. PMID: 40819663
Free Radic Biol Med

Therapeutic potential of plasma-treated solutions in atopic dermatitis. [Abstract]

2024 Nov 20:225:482-493. PMID: 39426754
Free Radic Biol Med

Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis. [Abstract]

2024 Nov 6:226:13-28. PMID: 39510452
Free Radic Biol Med

Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy. [Abstract]

2024 Jan:210:352-366. PMID: 38056575
Clin Transl Med

Tumour-derived SAA1 reprogrammes macrophages to promote CXCL1-mediated metastasis in Ovarian Cancer. [Abstract]

2026 May;16(5):e70698. PMID: 42145073
Cancer Immunol Res

CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer. [Abstract]

2026 May 4;14(5):875-891. PMID: 41686262
Cancer Immunol Res

Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis. [Abstract]

2025 Dec 9. PMID: 41364085
Cancer Immunol Res

METTL3 Inhibition Restores PD-L1 Expression and CD8+ T-cell Cytotoxic Function in Immunotherapy-Treated Gastric Cancer. [Abstract]

2025 Jul 2;13(7):1037-1052. PMID: 40299705
Clin Transl Med

The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis. [Abstract]

2025 Mar;15(3):e70263. PMID: 40045452
Clin Transl Med

Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms. [Abstract]

2024 Aug;14(8):e1799. PMID: 39118300
Stem Cell Res Ther

AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1+ macrophage polarization. [Abstract]

2025 Nov 14;16(1):639. PMID: 41239483
Am J Chin Med

Identification of Flavonoid Compounds in Treating Alzheimer's Disease Based on Network Medicine Framework Strategy. [Abstract]

2025 Aug 30:1-32. PMID: 40884807
Stem Cell Res Ther

Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury. [Abstract]

2025 Jun 3;16(1):286. PMID: 40462215
ACS Appl Mater Interfaces

Monitoring the Cascade of Monocyte-Derived Macrophages to Influenza Virus Infection in Human Alveolus Chips. [Abstract]

2024 Nov 6;16(44):60045-60055. PMID: 39450775
Br J Cancer

SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration. [Abstract]

2024 May;130(11):1770-1782. PMID: 38600327
Cell Rep

RBFOX2 suppresses NETosis and glioma growth via 5hmC-dependent PDGFB decay. [Abstract]

2026 Jun 11;45(6):117546. PMID: 42284147
Cell Rep

Mrgpra2+ neutrophils integrate infection-derived signals to trigger NET-mediated antimicrobial defense in bone marrow. [Abstract]

2026 Jun 22:117579. PMID: 42330955
Cell Rep

IRE1α regulates macrophage phagocytosis in immune thrombocytopenia through NR1D1 mRNA decay and lysosomal biogenesis. [Abstract]

2026 Mar 12;45(3):117083. PMID: 41824452
Cell Rep

Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM. [Abstract]

2025 Nov 25;44(11):116505. PMID: 41187060
Cell Rep

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]

2025 Sep 1;44(9):116139. PMID: 40892544
World J Gastroenterol

TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease. [Abstract]

2025 Aug 21;31(31):109605. PMID: 40901684
Cell Rep

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]

2025 Jun 13;44(6):115851. PMID: 40516055
Cell Rep

Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets. [Abstract]

2025 May 28;44(6):115771. PMID: 40440172
Cell Rep

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis. [Abstract]

2024 Dec 13;43(12):115060. PMID: 39673708
Cell Rep

Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC. [Abstract]

2024 Aug 7;43(8):114613. PMID: 39116206
Cell Rep

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy. [Abstract]

2024 Jul 31;43(8):114573. PMID: 39093701
Cell Rep

Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity. [Abstract]

2024 Mar 23;43(4):114003. PMID: 38527062
Cell Rep

Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER. [Abstract]

2023 Jun 27;42(7):112700. PMID: 37379216
Cell Rep

ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression. [Abstract]

2023 Jun 19;42(6):112654. PMID: 37342906
Cell Rep

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling. [Abstract]

2023 Mar 13;42(3):112259. PMID: 36920907
Cell Rep

TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. [Abstract]

2021 Jul 20;36(3):109404. PMID: 34289346
Br J Pharmacol

Neutrophil extracellular traps drive tubulointerstitial fibrosis via the coiled-coil domain-containing protein 25 (CCDC25)-Yes-associated protein 1 (YAP1) axis-mediated autophagy regulation. [Abstract]

2026 May 27. PMID: 42204873
Brain Behav Immun

Regulation of macrophage efferocytosis by the CLCF1/NF-κB pathway improves neurological and cognitive impairment following CO poisoning. [Abstract]

2025 Jul:127:126-146. PMID: 40081779
Br J Pharmacol

Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV-dependent and UV-independent melanogenesis. [Abstract]

2021 Dec;178(23):4646-4662. PMID: 34363226
Chin Med

Narcissoside attenuates atherosclerosis by suppressing CD36-mediated foam cell formation via upregulation of NR4A1. [Abstract]

2026 May 20;21(1):136. PMID: 42163363
Neurotherapeutics

The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome. [Abstract]

2026 Mar 30;23(3):e00895. PMID: 41916145
Chin Med

Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition. [Abstract]

2025 Dec 10;20(1):215. PMID: 41372934
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Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway. [Abstract]

2024 Apr 18;44(1):36. PMID: 38637346
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2026 Aug 13;69(15):18705-18722. PMID: 42470361
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2026 Jun 25.
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Targeted Degradation of Prolyl Hydroxylase Domain Enzyme 1 (PHD1) as a Novel Therapeutic Strategy for Acetaminophen-Induced Acute Liver Injury. [Abstract]

2026 May 13. PMID: 42126822
Clin Sci

Evaluation of inflammation-mediated cancer progression during FLASH and conventional irradiation-induced lung injury. [Abstract]

2026 Feb 11;140(2):201-219. PMID: 41552931
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Discovery of Novel Nonsteroidal SGRMs of Sulfonamide-2-Oxo-Tetrahydroquinoline Derivatives by Carbonyl Migration. [Abstract]

2026 Jan 22;69(2):1507-1529. PMID: 41490153
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Identification of 5,7-Dihydro-6 H-pyrrolo[2,3- d]pyrimidin-6-one Derivatives as ENPP1 Inhibitors for STING Pathway-Mediated Immunotherapy. [Abstract]

2025 Aug 14;68(15):16059-16075. PMID: 40711563
Environ Health (Wash)

Lung Single-Cell Transcriptomics Offers Insights into the Pulmonary Interstitial Toxicity Caused by Silica Nanoparticles. [Abstract]

2024 Jul 1;2(11):786-801. PMID: 39568699
J Med Chem

Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. [Abstract]

2022 Dec 8;65(23):15710-15724. PMID: 36399795
Environ Pollut

Silica-induced innate immune activation drives macrophage pyroptosis and lung inflammation through glycolytic reprogramming. [Abstract]

2025 Oct 1:382:126762. PMID: 40614958
Atherosclerosis

Isolinderalactone alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages. [Abstract]

2026 Jan 26:414:120648. PMID: 41759391
Front Immunol

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production. [Abstract]

2026 Jan 14:16:1684836. PMID: 41613144
Cancer Cell Int

DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]

2025 Nov 17;25(1):408. PMID: 41250029
J Invest Dermatol

MRGPRX2-Mediated Mast Cell Activation Promotes Malignant Progression of Cutaneous Squamous Cell Carcinoma through IL-17A Release. [Abstract]

2025 Nov 4:S0022-202X(25)03517-1. PMID: 41197765
J Invest Dermatol

A Sex-Specific Anti-Inflammatory Role for p62 in Psoriasis-Like Disease. [Abstract]

2025 Apr 19:S0022-202X(25)00413-0. PMID: 40258471
Front Immunol

Comprehensive multiomics analysis identifies PYCARD as a key pyroptosis-related gene in osteoarthritis synovial macrophages. [Abstract]

2025 Mar 24:16:1558139. PMID: 40196125
Front Immunol

S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis. [Abstract]

2024 May 17:15:1405622. PMID: 38827741
Cancer Cell Int

Targeting copper death genotyping associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration. [Abstract]

2023 May 29;23(1):105. PMID: 37246211
Emerg Microbes Infect

Interactions between host epithelial cells and Acinetobacter baumannii promote the emergence of highly antibiotic resistant and highly mucoid strains. [Abstract]

2022 Dec;11(1):2556-2569. PMID: 36227610
Front Immunol

Comprehensive Analyses Identify APOBEC3A as a Genomic Instability-Associated Immune Prognostic Biomarker in Ovarian Cancer. [Abstract]

2021 Oct 21;12:749369. PMID: 34745121
Front Immunol

Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation. [Abstract]

2021 May 20;12:653030. PMID: 34093541
PLoS Biol

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1. [Abstract]

2025 Nov 24;23(11):e3003490. PMID: 41284701
J Ethnopharmacol

Rexiao Kuining decoction ameliorates ulcerative colitis by restoring immune homeostasis via the protein kinase C alpha-FMS-like tyrosine kinase 3 ligand axis: multi-omics evidence. [Abstract]

2026 Nov 15:370:121985. PMID: 42264446
J Ethnopharmacol

Sanghuangporus vaninii extract exerts dual anti-tumor effects in colitis-associated colorectal cancer by direct cytotoxicity and macrophage reprogramming via the PPARγ/NF-κB axis. [Abstract]

2026 Jul 15:366:121657. PMID: 41974235
J Ethnopharmacol

Melampodium divaricatum (Rich.) DC. extracts exert anti-inflammatory effects via inhibition of the NLRP3 inflammasome. [Abstract]

2026 Oct 28:369:121903. PMID: 42202918
J Ethnopharmacol

Buyang Huanwu Decoction attenuates vascular aging by suppressing the pathway of neutrophil extracellular trap formation via modulation of the HMGB1/TLR4/p38 signaling pathway. [Abstract]

2026 May 10:362:121315. PMID: 41655726
JCI Insight

LYVE1 ectodomain shedding blunts lymphatic transmigration and clearance of macrophages during kidney injury. [Abstract]

2026 Jan 22;11(5):e195176. PMID: 41587141
J Ethnopharmacol

Modulation of the CEACAM1/TIM3 pathway by traditional Chinese medicine Xuebijing alleviates sepsis-induced acute lung injury through inhibition of NETs formation. [Abstract]

2025 Jul 10;353(Pt A):120280. PMID: 40651727
J Autoimmun

Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies. [Abstract]

2025 May:153:103411. PMID: 40179478
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Ginseng and Platycodon grandiflorum ameliorated pulmonary fibrosis and inflammation targeting TLR4-P2X7r/NLRP3 signaling pathway. [Abstract]

2025 May 28:348:119913. PMID: 40318772
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Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity. [Abstract]

2024 Apr 6:323:117711. PMID: 38176663
Eur J Med Chem

Synthesis and pharmacological evaluation of brominated derivatives of natural product celastrol for treatment of hepatic fibrosis. [Abstract]

2026 May 5:309:118765. PMID: 41844113
J Agric Food Chem

Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation. [Abstract]

2025 Oct 22;73(42):27089-27098. PMID: 41061708
Eur J Med Chem

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes. [Abstract]

2022 Jul 5;237:114338. PMID: 35436667
Eur J Med Chem

Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms. [Abstract]

2021 Jun 5:218:113388. PMID: 33784603
CNS Neurosci Ther

Angiotensin II Receptor-Associated Protein (AGTRAP) Enhances Glioma Cell Survival Through the IL-6/JAK2/STAT3 Pathway and Correlates With an Immunosuppressive Microenvironment. [Abstract]

2026 Feb;32(2):e70796. PMID: 41689202
Ecotoxicol Environ Saf

Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization. [Abstract]

2025 Dec:308:119481. PMID: 41319465
CNS Neurosci Ther

Vitamin D3 Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKCα/NOX4 Signaling Pathway. [Abstract]

2024 Sep;30(9):e70067. PMID: 39328008
Ecotoxicol Environ Saf

Nicotine induces macrophage pyroptosis via LINC01272/miR-515/KLF6 axis. [Abstract]

2023 Sep 15:263:115265. PMID: 37478567
Ecotoxicol Environ Saf

The protective role of HMGB1 in affecting the balance between autophagy and pyroptosis to maintain neutrophils homeostasis during β-glucan-induced mice lung inflammation. [Abstract]

2023 Mar 1:252:114637. PMID: 36774802
Ecotoxicol Environ Saf

Nuclear factor-kappaB mediates the survival of rat kidney cells after cadmium exposure via promoting autophagy and inhibiting apoptosis. [Abstract]

2023 Jan 1:249:114465. PMID: 38321684
Biochem Pharmacol

2026 Oct:252:118206. PMID: 42378776
Biochem Pharmacol

Recruitment of tumor-associated macrophages via the CCL4-CCR5 axis promotes immune escape through PD-1 signaling in lung adenocarcinoma. [Abstract]

2026 Jul:249:117925. PMID: 41876018
Biochem Pharmacol

Hypoxia-driven TCF21/CCL11 axis in GCMSCs orchestrates macrophage polarization and lymphatic remodeling to promote gastric cancer lymph node metastasis. [Abstract]

2026 May 14;250(Pt 2):118056. PMID: 42134670
Cell Mol Life Sci

Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates. [Abstract]

2025 May 28;82(1):218. PMID: 40434714
Biochem Pharmacol

Repurposing TAK875 as a novel STAT3 inhibitor for treating inflammatory bowel disease. [Abstract]

2024 Jan:219:115957. PMID: 38049007
Cell Biosci

Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice. [Abstract]

2023 Aug 21;13(1):154. PMID: 37605246
Biochem Pharmacol

STING activation in macrophages by vanillic acid exhibits antineoplastic potential. [Abstract]

2023 Jul:213:115618. PMID: 37211172
Mol Ther Nucleic Acids

DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD. [Abstract]

2021 Dec 11:27:375-389. PMID: 35036051
Life Sci

G0S2 drives lipid metabolism disorders and oxidative stress to promote M1 macrophage polarization and inflammation in polycystic ovary syndrome. [Abstract]

2026 Jul 15:397:124392. PMID: 41985712
Cell Insight

Capicua mediates interleukin-2 withdrawal-induced death of activated CD8+ T cells. [Abstract]

2026 Apr 2;5(3):100323. PMID: 42011339
Life Sci

Exploring the hepatoprotective effects of perillyl alcohol in the experimental models of acute liver injury. [Abstract]

2025 Nov 1:380:123926. PMID: 40850494
Life Sci

Homoyessotoxin alleviates inflammatory responses by regulating the TLR4/MyD88/NFκB and Nrf2/HO-1 pathways. [Abstract]

2025 Oct 15:379:123858. PMID: 40669807
Life Sci

M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis. [Abstract]

2025 Jun 1:370:123561. PMID: 40127859
Life Sci

Targeting the HDAC6/Hint2/MICU1 axis to ameliorate acute liver failure via inhibiting NETosis. [Abstract]

2025 Apr 1:366-367:123498. PMID: 39983829
Life Sci

TPX2 influences the regulation of macrophage polarization via the NF-κB pathway in lung adenocarcinoma. [Abstract]

2024 Mar 1:340:122437. PMID: 38266813
Life Sci

PGRN-/- TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration. [Abstract]

2021 Jan 1:264:118687. PMID: 33181174
Life Sci

Epigenetic modulation of glycoprotein VI gene expression by DNA methylation. [Abstract]

2020 Jan 15:241:117103. PMID: 31783053
Life Sci

FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway. [Abstract]

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Food Biosci

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Oncoimmunology

Inhibiting SLAMF8 modulates tumor-associated macrophages and restores CD8+ T cell-mediated antitumor immunity in colorectal cancer. [Abstract]

2025 Dec 31;14(1):2581910. PMID: 41211891
Inflamm Res

Molecular profiling of core immune-escape genes highlights TNFAIP3 as an immune-related prognostic biomarker in neuroblastoma. [Abstract]

2024 Sep;73(9):1529-1545. PMID: 39028490
Inflamm Res

Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis. [Abstract]

2024 Jun;73(6):961-978. PMID: 38587531
Inflamm Res

Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice. [Abstract]

2024 Jun;73(6):945-960. PMID: 38587532
Oncoimmunology

CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage. [Abstract]

2024 May 10;13(1):2352179. PMID: 38746869
Drug Des Devel Ther

Morin Regulates M1/M2 Microglial Polarization via NF-κB p65 to Alleviate Vincristine-Induced Neuropathic Pain. [Abstract]

2024 Jul 22:18:3143-3156. PMID: 39071815
Cells

2026 Jul 27;15(15):1349. PMID: 42587759
EMBO Rep

CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity. [Abstract]

2025 Nov 17. PMID: 41249580
EMBO Rep

Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex. [Abstract]

2025 Sep 16. PMID: 40958049
J Clin Transl Hepatol

CCNE1 Promotes the Progression of Hepatic Precancerous Lesion and the Malignant Phenotype of Hepatocellular Carcinoma. [Abstract]

2025 Jul 28;13(7):555-567. PMID: 40937080
Cells

Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro. [Abstract]

2025 May 8;14(10):678. PMID: 40422181
J Am Heart Assoc

HMGB1-Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice. [Abstract]

2022 Feb 15;11(4):e023800. PMID: 35156391
J Funct Biomater

2026 Jun 26;17(7):312. PMID: 42506538
Cancer Immunol Immunother

CXCL9/SPP1-polarized tumor-associated macrophages exert dual roles in regulating anti-tumor immunity in lung adenocarcinoma. [Abstract]

2026 Jun 16. PMID: 42301510
Commun Biol

Pseudorabies virus infection induces IRF1-dependent PANoptosis to provoke the excessive release of HMGB1 and IL-1β. [Abstract]

2026 Jun 5. PMID: 42249111
Cancer Immunol Immunother

A novel oncolytic herpes simplex virus type 2 induces polarization of tumor-associated macrophages and remodels the immune microenvironment in glioblastoma. [Abstract]

2026 May 30. PMID: 42217049
Mol Cancer Res

ID4 suppresses proliferation and macrophage polarization in esophageal carcinoma through interaction with TCF4. [Abstract]

2026 Mar 2. PMID: 41770101
Cancer Immunol Immunother

SLC16A3 in lung adenocarcinoma regulates glycolysis and lactate release to facilitate M2 polarization of tumor-associated macrophages : Short Title: SLC16A3 reinforces macrophage M2 polarization through glycolysis. [Abstract]

2025 Dec 23;75(1):25. PMID: 41432987
Cancer Immunol Immunother

MS4A1 regulates M1-polarized tumor-associated macrophage infiltration, angiogenesis, and cancer progression through the HIPPO pathway in lung adenocarcinoma. [Abstract]

2025 Nov 3;74(12):356. PMID: 41182411
Nutrients

Dietary Copper on the Onset of Puberty in Rats: Possible Mechanism. [Abstract]

2025 Nov 12;17(22):3534. PMID: 41305585
Cancer Immunol Immunother

Integrating necroptosis and immune landscapes: a multi-omics-derived NecropImmScore stratifies prognosis and therapy in ovarian cancer. [Abstract]

2025 Oct 15;74(11):340. PMID: 41094064
Commun Biol

Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway. [Abstract]

2025 Mar 12;8(1):417. PMID: 40074811
Commun Biol

Defining gastric cancer ecology: the crucial roles of TREM2+ macrophages and fibroblasts in tumor microenvironments. [Abstract]

2025 Mar 28;8(1):514. PMID: 40155473
Cancer Immunol Immunother

SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma cells. [Abstract]

2025 Feb 1;74(3):87. PMID: 39891717
Cancer Immunol Immunother

STC1 encapsulated in small extracellular vesicles from laryngeal squamous cell carcinoma cells induces CD8+ T cell dysfunction by reprogramming tumor-associated macrophages into M2-like macrophages. [Abstract]

2025 Jan 3;74(2):64. PMID: 39751648
Cancer Immunol Immunother

Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma. [Abstract]

2024 Nov 2;74(1):11. PMID: 39487876
Cancer Immunol Immunother

Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer. [Abstract]

2023 Jun;72(6):1917-1932. PMID: 36729212
Nutrients

Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages. [Abstract]

2020 Oct 11;12(10):3088. PMID: 33050595
Eur J Pharmacol

Therapeutic potential of oral edaravone in diabetic endothelial dysfunction through NF-κB and p38 pathway inhibition. [Abstract]

2026 Jan 20:1012:178500. PMID: 41421410
Eur J Pharmacol

Remimazolam alleviates acute lung injury via translocator protein mediated inhibition of the NF-κB pathway. [Abstract]

2026 Feb 10:1014:178540. PMID: 41519458
Cancer Biol Ther

CD44v5 enhances the IL-4/IL-4Rα/STAT6/SAM68 aix inducing M2 polarization and promoting triple-negative breast cancer progression. [Abstract]

2025 Dec 31;26(1):2589658. PMID: 41319154
Respir Res

MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization. [Abstract]

2025 Jul 10;26(1):238. PMID: 40640787
Pharmaceuticals (Basel)

In Vitro and In Vivo Assessment of Pharmacokinetic Profile of Peramivir in the Context of Inhalation Therapy. [Abstract]

2025 Jan 29;18(2):181. PMID: 40005995
Eur J Pharmacol

Cinobufagin modulates vasculogenic mimicry and tumor-associated macrophages to inhibit ovarian cancer progression. [Abstract]

2025 Jan 15:987:177157. PMID: 39617163
Eur J Pharmacol

Cylindrin from Imperata cylindrica inhibits M2 macrophage formation and attenuates renal fibrosis by downregulating the LXR-α/PI3K/AKT pathway. [Abstract]

2023 Jul 5:950:175771. PMID: 37146709
Pharmaceuticals (Basel)

Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing. [Abstract]

2023 Jun 15;16(6):885. PMID: 37375833
Acta Physiol

The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function. [Abstract]

2023 Apr;237(4):e13926. PMID: 36606511
Int Immunopharmacol

Electroacupuncture protects intestinal barrier integrity in MAFLD mice and is associated with a macrophage α7nAChR/exosomal miR-217-5p/epithelial HO-1 signaling axis. [Abstract]

2026 Aug 15:183:116879. PMID: 42161050
Biomolecules

2026 Aug;16(8):1081.
Int Immunopharmacol

Paeonol mitigates age-related osteoporosis via mitophagy-mediated NLRP3 inflammasome inhibition. [Abstract]

2026 Aug 1:182:116787. PMID: 42096961
Int Immunopharmacol

Clostridium butyricum alleviates DSS-induced colitis by suppressing neutrophil extracellular trap formation via the IL-17 pathway. [Abstract]

2026 Jul 15:181:116770. PMID: 42070310
Cell Oncol (Dordr)

P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer. [Abstract]

2026 Jun 6. PMID: 42250059
Int Immunopharmacol

CTSK+ macrophages drive fibrotic stenosis in benign airway stenosis via the PROS1-AXL pathway. [Abstract]

2026 Jun 16:185:117018. PMID: 42302376
Int Immunopharmacol

Celastrol protects against renal tubular injury in early diabetic kidney disease through modulation of NOX2 and ferroptosis. [Abstract]

2026 May 15:177:116533. PMID: 41861539
Int Immunopharmacol

Sakuranetin ameliorates joint inflammation and bone erosion in rheumatoid arthritis by suppressing NLRP3 inflammasome-mediated inflammatory signaling. [Abstract]

2026 May 15:177:116542. PMID: 41864012
Int Immunopharmacol

UBE2C-PI3K/AKT-mediated upregulation of MTHFD2 promotes tumor progression in hepatocellular carcinoma. [Abstract]

2026 Feb 1:170:116081. PMID: 41456492
Int Immunopharmacol

Oleanolic acid alleviates intestinal injury after hepatic ischemia-reperfusion under steatosis via PPARG-dependent M2 macrophage polarization. [Abstract]

2026 Feb 15:171:116162. PMID: 41494252
Int Immunopharmacol

Nimbolide inhibits NLRP3 inflammasome activation via blocking NEK7-NLRP3 interaction and alleviates sepsis-induced lung injury. [Abstract]

2026 Jan 1;168(Pt 2):115954. PMID: 41319565
Int Immunopharmacol

Impact of the combination of diet with environment exposures on an eczema mouse model. [Abstract]

2026 Jan 1;168(Pt 1):115803. PMID: 41218583
Int Immunopharmacol

Microbial metabolite tigloside alleviates osteoarthritis by repolarizing macrophages from M1 to M2 phenotype through Trafd1 destabilization and Trafd1-mediated NF-κB/STAT6 signaling pathways. [Abstract]

2026 Jan 1;168(Pt 1):115747. PMID: 41192114
Int Immunopharmacol

GPRC5A+ myCAFs promote ESCC progression via TGF-β-induced fibroblast activation and ANXA1-mediated M2 macrophage polarization. [Abstract]

2025 Dec 10:167:115663. PMID: 41082840
Int J Mol Sci

Synovial CXCL3+FOSL2+ Macrophages Mediate Inflammation via FOSL2/AP-1 in Rheumatoid Arthritis: A Single-Cell Transcriptome Analysis. [Abstract]

2025 Oct 6;26(19):9718. PMID: 41096984
Int Immunopharmacol

Bruceine D promotes TNBC regression by inhibiting M2-like tumor-associated macrophage polarization induced Wnt3a/β-catenin pathway. [Abstract]

2025 Sep 23:166:115596. PMID: 40991998
Int Immunopharmacol

Timosaponin AIII from Anemarrhena asphodeloides binds and inhibits S100A8-mediated neutrophil infiltration and NET formation ameliorates MASH. [Abstract]

2025 Sep 20:166:115539. PMID: 40976053
Int Immunopharmacol

Cucurbitacin B suppresses malignant progression of oral leukoplakia via ferroptosis-induced macrophage polarization. [Abstract]

2025 Sep 13:165:115485. PMID: 40946669
Noncoding RNA Res

Aerobic exercise alleviates allergic airway inflammation by suppressing circMETTL9-mediated formation of macrophage extracellular traps. [Abstract]

2025 Aug 29:15:156-171. PMID: 41169933
Int Immunopharmacol

High ELK3 expression is associated with the wild type IDH1 in glioma and enhances infiltration of M2 macrophages. [Abstract]

2025 Aug 28:161:115064. PMID: 40513332
Int Immunopharmacol

Narirutin attenuates LPS-induced neuroinflammatory responses in both microglial cells and wild-type mice. [Abstract]

2025 Jun 26:159:114954. PMID: 40424653
Int Immunopharmacol

IDH1/MDH1 deacetylation activates the cGAS-STING pathway by promoting NETosis in acute liver failure. [Abstract]

2025 Jun 17:158:114884. PMID: 40388861
Int Immunopharmacol

The natural compound PEITC ameliorates imiquimod-induced psoriasis in mice by suppressing neutrophil extracellular traps formation. [Abstract]

2025 Jun 26:159:114939. PMID: 40414074
Int J Mol Sci

CD71-Mediated Effects of Soluble Vasorin on Tumor Progression, Angiogenesis and Immunosuppression. [Abstract]

2025 May 20;26(10):4913. PMID: 40430053
Int J Mol Sci

Mechanical Force Triggers Macrophage Pyroptosis and Sterile Inflammation by Disrupting Cellular Energy Metabolism. [Abstract]

2025 Apr 2;26(7):3321. PMID: 40244158
Int Immunopharmacol

SPP1-mediated M2 macrophage polarization shapes the tumor microenvironment and enhances prognosis and immunotherapy guidance in nasopharyngeal carcinoma. [Abstract]

2025 Feb 6:147:113944. PMID: 39742726
Biomolecules

PAR2 Participates in the Development of Cough Hypersensitivity in Guinea Pigs by Regulating TRPA1 Through PKC. [Abstract]

2025 Feb 1;15(2):208. PMID: 40001511
Int Immunopharmacol

HSPA5-mediated glioma hypoxia tolerance promotes M2 macrophage polarization under hypoxic microenvironment. [Abstract]

2025 Feb 6:147:113856. PMID: 39740502
Int J Mol Sci

Oxymatrine Ameliorates Lupus Nephritis by Targeting the YY1-Mediated IL-6/STAT3 Axis. [Abstract]

2024 Nov 14;25(22):12260. PMID: 39596325
Int Immunopharmacol

OSU-T315 overcomes immunosuppression in triple-negative breast cancer by targeting the ILK/NF-κB signaling pathway to enhance immunotherapeutic efficacy. [Abstract]

2024 Nov 7;143(Pt 3):113530. PMID: 39515039
Int Immunopharmacol

M2 Macrophage exosomal HOXC13-AS in laryngeal cancer immunity via targeting miR-485-5p/IGF2BP2/PD-L1. [Abstract]

2024 Oct 25:140:112742. PMID: 39126735
Int Immunopharmacol

Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization. [Abstract]

2024 Oct 14;143(Pt 1):113323. PMID: 39405940
Int Immunopharmacol

The VDR/FFAR2 axis mitigates sepsis-induced lung injury by suppressing macrophage lipid peroxidation. [Abstract]

2024 Oct 16;143(Pt 2):113328. PMID: 39418731
Int Immunopharmacol

Tumor-associated macrophages induce epithelial-mesenchymal transition and promote lung metastasis in breast cancer by activating the IL-6/STAT3/TGM2 axis. [Abstract]

2024 Oct 18;143(Pt 2):113387. PMID: 39426226
Int Immunopharmacol

IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy. [Abstract]

2024 Sep 30;143(Pt 1):113270. PMID: 39353390
Int Immunopharmacol

Chinese medicine compound prescription HeQi San ameliorates chronic inflammatory states and modulates gut flora in dehydroepiandrosterone-induced polycystic ovary syndrome mouse model. [Abstract]

2024 Aug 20:137:112491. PMID: 38909499
Int Immunopharmacol

Fecal microbiota transplantation regulates the microbiota-gut-spinal cord axis to promote recovery after spinal cord injury. [Abstract]

2024 Jan 5:126:111212. PMID: 37979452
Int Immunopharmacol

Tryptophan metabolism regulates inflammatory macrophage polarization as a predictive factor for breast cancer immunotherapy. [Abstract]

2023 Dec;125(Pt B):111196. PMID: 37972471
Int Immunopharmacol

Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-κB pathways. [Abstract]

2023 Oct:123:110763. PMID: 37567009
Int Immunopharmacol

Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma. [Abstract]

2023 Oct:123:110685. PMID: 37494837
Int Immunopharmacol

Human umbilical cord-derived mesenchymal stromal cells alleviate liver cirrhosis through the Hippo/YAP/Id1 pathway and macrophage-dependent mechanism. [Abstract]

2023 Oct:123:110456. PMID: 37494836
Int J Mol Sci

Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway. [Abstract]

2023 Sep 30;24(19):14771. PMID: 37834220
Int J Mol Sci

Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10. [Abstract]

2023 Sep 30;24(19):14808. PMID: 37834257
Int Immunopharmacol

Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway. [Abstract]

2023 Jul:120:110378. PMID: 37244119
Int J Mol Sci

R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis. [Abstract]

2023 Feb 27;24(5):4588. PMID: 36902020
Int Immunopharmacol

Extracellular citrate serves as a DAMP to activate macrophages and promote LPS-induced lung injury in mice. [Abstract]

2021 Dec;101(Pt B):108372. PMID: 34810128
Int Immunopharmacol

Senkyunolide I protect against lung injury via inhibiting formation of neutrophil extracellular trap in a murine model of cecal ligation and puncture. [Abstract]

2021 Oct:99:107922. PMID: 34224996
Int Immunopharmacol

Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment. [Abstract]

2021 May:94:107455. PMID: 33582592
Int Immunopharmacol

Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions. [Abstract]

2020 Apr:81:106030. PMID: 31796385
Int Immunopharmacol

Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway. [Abstract]

2018 Dec:65:458-469. PMID: 30390593
Mol Neurobiol

GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification. [Abstract]

2025 May;62(5):5501-5517. PMID: 39560901
Antibiotics (Basel)

The Tick Saliva Peptide HIDfsin2 TLR4-Dependently Inhibits the Tick-Borne Severe Fever with Thrombocytopenia Syndrome Virus in Mouse Macrophages. [Abstract]

2024 May 15;13(5):449. PMID: 38786177
Immunology

STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis. [Abstract]

2026 Mar 3. PMID: 41775627
Inflammation

Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]

2025 Dec 20;49(1):11. PMID: 41420798
BMC Biol

Bradykinin's carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction. [Abstract]

2025 Mar 12;23(1):76. PMID: 40075424
Immunology

Hypoxic tumour-derived exosomal miR-1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization. [Abstract]

2024 Dec;173(4):672-688. PMID: 39183579
J Periodontal Res

Caspase-3 and gasdermin E mediate macrophage pyroptosis in periodontitis. [Abstract]

2024 Feb;59(1):140-150. PMID: 37885312
Inflammation

Small Extracellular Vesicles from Periodontal Ligament Stem Cells Primed by Lipopolysaccharide Regulate Macrophage M1 Polarization via miR-433-3p Targeting TLR2/TLR4/NF-κB. [Abstract]

2023 Oct;46(5):1849-1858. PMID: 37351818
Front Pharmacol

Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway. [Abstract]

2021 May 13:12:655726. PMID: 34054535
Front Pharmacol

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. [Abstract]

2020 Jul 31:11:1038. PMID: 32903813
Front Pharmacol

Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway. [Abstract]

2020 Jan 28:10:1589. PMID: 32116659
Probiotics Antimicrob Proteins

Potential Benefits of Metformin Via Roseburia Intestinalis in High-fat Diet-fed Mice With Colorectal Adenomas. [Abstract]

2025 Nov 26. PMID: 41296177
Front Cell Dev Biol

Enhancing Fatty Acid Catabolism of Macrophages Within Aberrant Breast Cancer Tumor Microenvironment Can Re-establish Antitumor Function. [Abstract]

2021 Apr 15:9:665869. PMID: 33937269
Chem Biol Interact

Phenylalanine metabolism as a key pathway in polystyrene microplastics-induced abnormal macrophage polarization: Implications for fetal growth and development. [Abstract]

2026 Aug 1:436:112213. PMID: 42303205
Int Dent J

Pulpal Pressure Aggravates Pulpitis by Mechano-Inflammatory Signal Synergy. [Abstract]

2026 Jun 27;76(5):109698. PMID: 42364415
Chem Biol Interact

Fusobacterium nucleatum-derived 3-indolepropionic acid promotes colorectal cancer progression via aryl hydrocarbon receptor activation in macrophages. [Abstract]

2025 Jun 1:414:111495. PMID: 40174685
Toxicology

A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction. [Abstract]

2024 May 11:153829. PMID: 38740170
ACS Omega

Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity. [Abstract]

2022 Aug 5;7(32):28334-28341. PMID: 35990425
Molecules

β,β-Dimethylacrylalkannin, a Natural Naphthoquinone, Inhibits the Growth of Hepatocellular Carcinoma Cells by Modulating Tumor-Associated Macrophages. [Abstract]

2024 Aug 20;29(16):3919. PMID: 39202998
Molecules

Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. [Abstract]

2023 Nov 10;28(22):7527. PMID: 38005247
Biochim Biophys Acta Mol Basis Dis

2026 Nov;1872(8):168382. PMID: 42498053
Clin Exp Allergy

Prognostic Significance of Eosinophil Extracellular Traps in Chronic Rhinosinusitis and Innovative Nanosheets-Based Clearance Therapy. [Abstract]

2026 Feb 12. PMID: 41679737
Mol Med Rep

CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis. [Abstract]

2026 Jan;33(1):44. PMID: 41268607
Food Sci Nutr

Spatial Domain-Based Approach to Analyze the Mechanism of Sparganii Rhizoma-Curcumae Rhizoma Pair in the Treatment of Colorectal Cancer. [Abstract]

2025 Aug 19;13(8):e70794. PMID: 40842663
Biochim Biophys Acta Mol Basis Dis

Small extracellular vesicles from HO-1 modified BMMSCs alleviate steatotic liver grafts ischemia-reperfusion injury by delivering PDIA4 to promote reparative macrophage polarization. [Abstract]

2025 Jun 9;1871(7):167947. PMID: 40494182
Mol Med Rep

N‑methyladenosine reader YTHDF2‑mediated AC026691.1 degradation promotes gastric cancer cell proliferation, migration and M2 macrophage polarization. [Abstract]

2025 May;31(5):120. PMID: 40052573
Mol Med Rep

Targeted degradation of hexokinase 2 for anti‑inflammatory treatment in acute lung injury. [Abstract]

2024 May;29(5):83. PMID: 38516767
Sci Rep

2026 Jul 11. PMID: 42436337
Sci Rep

Multi-target regulation mechanisms of systemic lupus erythematosus, a network pharmacology and molecular docking study on active compounds from Artemisia argyi. [Abstract]

2026 Jul 10. PMID: 42432303
Cancer Sci

2026 Jun 30. PMID: 42374997
Transl Oncol

Deciphering IFN signaling in gastric cancer: A single-cell and bulk transcriptomic integration reveals CXCR4 as a key immunomodulator and prognostic determinant. [Abstract]

2026 Jun:68:102778. PMID: 42019279
Sci Rep

IL-36 activates neutrophil extracellular traps and exacerbates LPS-induced ARDS in mice. [Abstract]

2026 May 9;16(1):21231. PMID: 42103804
Sci Rep

FNDC1 is closely related to poor prognosis and immune cell infiltration in gastric cancer. [Abstract]

2026 Apr 15;16(1):17490. PMID: 41986425
Sci Rep

Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization. [Abstract]

2026 Mar 31. PMID: 41917130
Sci Rep

DUSP6 promotes motility, invasion, and tumorigenicity of thyroid cancer cells via IL8-induced neutrophil extracellular traps. [Abstract]

2026 Mar 8;16(1):12575. PMID: 41796219
APL Bioeng

Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis. [Abstract]

2026 Jan 30;10(1):016107. PMID: 41624806
Sci Rep

Transcriptome analysis combined with single-cell analysis identified that APOC1 influences cholesterol transport by macrophages in ccRCC. [Abstract]

2025 Oct 6;15(1):34724. PMID: 41053280
Sci Rep

Constitutive interaction between neutrophils and von Willebrand factor in peripheral blood. [Abstract]

2025 Jul 10;15(1):24895. PMID: 40640566
PLoS Pathog

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. [Abstract]

2025 Jul 16;21(7):e1013344. PMID: 40668819
Sci Rep

Identification of natural killer cell-characteristic genes in atherosclerosis based on bioinformatics analysis. [Abstract]

2025 May 16;15(1):17112. PMID: 40379756
Transl Oncol

Tumor-stroma proportion is associated with increased M2 macrophage abundance and predicts the resistance to immune checkpoint blockade in breast cancer. [Abstract]

2025 Apr:54:102343. PMID: 40068383
World J Stem Cells

Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis. [Abstract]

2025 Apr 26;17(4):103919. PMID: 40308884
Transl Oncol

Thiostrepton suppresses intrahepatic cholangiocarcinoma progression via FOXM1-mediated tumor-associated macrophages reprogramming. [Abstract]

2025 Feb 21:54:102327. PMID: 39986191
Sci Rep

Innovative peptide therapeutics targeting IL17RA to regulate inflammatory responses. [Abstract]

2025 Mar 22;15(1):8542. PMID: 40121226
J Mol Cell Cardiol

SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway. [Abstract]

2024 Nov:196:71-83. PMID: 39245317
PLoS Pathog

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages. [Abstract]

2024 Sep 9;20(9):e1012543. PMID: 39250507
PLoS Pathog

MARCH2, a T cell specific factor that restricts HIV-1 infection. [Abstract]

2024 Jul 29;20(7):e1012330. PMID: 39074162
Cancer Sci

Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T-cell lymphoma via TLR4 signaling pathway. [Abstract]

2024 Jul;115(7):2444-2460. PMID: 38613253
Dig Liver Dis

TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization. [Abstract]

2024 Jul;56(7):1237-1247. PMID: 38151453
Sci Rep

Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3. [Abstract]

2024 Mar 4;14(1):5237. PMID: 38433281
J Mol Cell Cardiol

MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1. [Abstract]

2020 Jun;143:1-14. PMID: 32278833
Mediators Inflamm

Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide. [Abstract]

2020 Feb 29:2020:2720369. PMID: 32189992
Eur J Med Res

2026 Apr 24;31(1):843.
Eur J Med Res

The miR-3164/PAD4 axis regulates NETosis to prevent airway inflammation and remodeling through the TLR2/NF-κB signaling pathway. [Abstract]

2025 Oct 9;30(1):947. PMID: 41068990
Eur J Med Res

GDF-15 upregulates the SLC7A11/GPX4 signaling axis and promotes mitoxantrone resistance in AML cells. [Abstract]

2025 Jun 21;30(1):504. PMID: 40544302
Eur J Med Res

Invisible appliance promotes bone reconstruction via modulating the periodontal immune microenvironment. [Abstract]

2025 May 12;30(1):378. PMID: 40350478
Eur J Med Res

GATA1-mediated macrophage polarization via TrkB/cGMP-PKG signaling pathway to promote the development of preeclampsia. [Abstract]

2025 Jan 7;30(1):12. PMID: 39773303
Cancers (Basel)

MICA+ Tumor Cell Upregulated Macrophage-Secreted MMP9 via PROS1-AXL Axis to Induce Tumor Immune Escape in Advanced Hepatocellular Carcinoma (HCC). [Abstract]

2024 Jan 8;16(2):269. PMID: 38254761
Cell Signal

FOLR2+ tumor-associated macrophages drive metastatic microenvironment remodeling and lymphatic dissemination in colorectal cancer. [Abstract]

2026 Oct:146:112676. PMID: 42297063
Neuropharmacology

CXCL10 activates STAT3 signaling to promote ferroptosis in the spinal dorsal horn during neuropathic pain. [Abstract]

2026 Aug 1:293:110965. PMID: 41951153
Mol Cell Biochem

CCL3 promotes oxaliplatin resistance in gastric cancer via CCR5-mediated tumor cell survival and macrophage M2 polarization. [Abstract]

2026 Jun 19. PMID: 42319715
J Cell Mol Med

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma. [Abstract]

2026 Jan;30(1):e71000. PMID: 41486508
J Cell Mol Med

ZBP1, an M1 Macrophage-Associated Biomarker Identified by Machine Learning, Suppresses Tumorigenesis and Predicts Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. [Abstract]

2025 Nov;29(22):e70953. PMID: 41299204
J Cell Mol Med

The Flavonoid Kaempferol Mitigates Periprosthetic Osteolysis by Regulating the NLRP3 Inflammasome and Balancing Bone Metabolism. [Abstract]

2025 Oct;29(19):e70878. PMID: 41053962
J Cell Mol Med

RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response. [Abstract]

2025 Oct;29(20):e70915. PMID: 41126439
Cell Signal

Proguanil inhibits proliferation and migration in glioblastoma development through targeting CSF1R receptor. [Abstract]

2025 Mar:127:111550. PMID: 39662608
Cell Signal

Single-cell analysis reveals that TCF7L2 facilitates the progression of ccRCC via tumor-associated macrophages. [Abstract]

2024 Dec:124:111453. PMID: 39366533
J Cell Mol Med

Anti-inflammatory effect of Trichospira verticillata via suppression of the NLRP3 inflammasome in neutrophilic asthma. [Abstract]

2024 Apr;28(8):e18356. PMID: 38668995
J Cell Mol Med

ER-α36 is involved in calycosin inhibition of IL-6 production in macrophages. [Abstract]

2024 Jan;28(1):e18037. PMID: 37974543
Med Oncol

FAT4 activation inhibits epithelial-mesenchymal transition (EMT) by promoting autophagy in H2228/Cer cells. [Abstract]

2022 Dec 28;40(1):64. PMID: 36576661
Cell Signal

CLDN6 inhibits breast cancer cell malignant behavior by suppressing ERK signaling. [Abstract]

2022 Sep:97:110393. PMID: 35752352
Cell Signal

KLF14 alleviated breast cancer invasion and M2 macrophages polarization through modulating SOCS3/RhoA/Rock/STAT3 signaling. [Abstract]

2022 Apr:92:110242. PMID: 34998931
Cell Signal

Mechanism of neutrophil extracellular traps generation and their role in trophoblasts apoptosis in gestational diabetes mellitus. [Abstract]

2021 Dec:88:110168. PMID: 34634453
J Inflamm Res

Yi-qi-hua-yu-jie-du Decoction Inhibits Gastric Cancer Progression by Inducing Tumor-Associated Macrophage Polarization via Modulating PP2A Enzyme Activity to Mediate the PI3K/AKT/NF-κB Axis. [Abstract]

2026 May 12:19:568022. PMID: 42152943
Oncol Res

SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]

2026 Jan 19;34(2):25. PMID: 41613800
J Inflamm Res

Interleukin-27 and Interleukin-2 Cooperatively Regulate CD4⁺ T Cell Subsets and Immune Imbalance in Coronary Artery Disease. [Abstract]

2025 Dec 10:18:17253-17269. PMID: 41399529
J Inflamm Res

Downregulated RSAD2 Attenuates the Apoptosis of LPS-Stimulated RAW264.7 via NF-κB Signaling Pathway. [Abstract]

2025 Aug 12:18:10939-10952. PMID: 40823355
J Inflamm Res

Calycosin-7-Glucoside Alleviates Atherosclerosis by Inhibiting Ox-LDL-Induced Foam Cell Formation and Inflammatory Response in THP-1-Derived Macrophages via ATF-1 Activation Through the p38/MAPK Pathway. [Abstract]

2025 Apr 25:18:5573-5586. PMID: 40303003
J Inflamm Res

Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury. [Abstract]

2025 Mar 19:18:4143-4156. PMID: 40125085
J Inflamm Res

FLI1 Induces Plaque Psoriasis and Its Inhibition Attenuates Disease Progression. [Abstract]

2025 Mar 20:18:4213-4231. PMID: 40129872
J Inflamm Res

Benidipine Hydrochloride Inhibits NLRP3 Inflammasome Activation by Inhibiting LPS-Induced NF-κB Signaling in THP-1 Macrophages. [Abstract]

2024 Sep 11:17:6307-6316. PMID: 39281771
J Innate Immun

Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma. [Abstract]

2021;13(1):38-48. PMID: 33271553
iScience

2026 Jul 14;29(8):116793. PMID: 42519027
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2026 Jul 1;29(7):116360. PMID: 42491464
Biomedicines

HIF-1α Promotes Macrophage Extracellular Trap Formation and Exacerbates Acute Lung Injury in Neonatal Sepsis. [Abstract]

2026 May 18;14(5):1145. PMID: 42193470
Neurochem Res

Electroacupuncture Stimulation of the Head Motor Area Alleviates Brain Cell Pyroptosis and Neurobehaviors in Stroke Rats Through the NF-κB/NLRP3 Signaling Axis. [Abstract]

2026 Apr 27;51(3):146. PMID: 42043662
Poult Sci

Targeting TatD nuclease and the MAPK Pathway: Luteolin multifaceted approach against Mycoplasma gallisepticum infection. [Abstract]

2026 Jan 12;105(3):106426. PMID: 41548475
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2025 Dec 3.
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M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor. [Abstract]

2025 Sep 5;28(10):113517. PMID: 41031375
Clin Exp Med

HCQ reverses the immune imbalance related to severe infections following chemotherapy of acute myeloid leukemia and exhibits inhibitory effects on inflammatory cytokine storms. [Abstract]

2025 Aug 15;25(1):294. PMID: 40815351
iScience

AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease. [Abstract]

2025 May 13;28(7):112658. PMID: 40687779
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Atractylodin modulates ASAH3L to improve galactose metabolism and inflammation to alleviate acute lung injury. [Abstract]

2024 Aug 31;27(10):110751. PMID: 39351199
Mol Nutr Food Res

Pretreatment with Kahweol Attenuates Sepsis-Induced Acute Lung Injury via Improving Mitochondrial Homeostasis in a CaMKKII/AMPK-Dependent Pathway. [Abstract]

2023 Oct;67(19):e2300083. PMID: 37483173
iScience

Elabela inhibits TRAF1/NF-κB induced oxidative DNA damage to promote diabetic foot ulcer wound healing. [Abstract]

2023 Aug 9;26(9):107601. PMID: 37664606
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TSC22D3 as an immune-related prognostic biomarker for acute myeloid leukemia. [Abstract]

2023 Jul 22;26(8):107451. PMID: 37575189
Comp Biochem Physiol C Toxicol Pharmacol

The role of intercellular junction proteins in the penetration resistance of Drosophila larvae to avermectin. [Abstract]

2023 Apr:266:109557. PMID: 36717043
Endocr Relat Cancer

COL12A1 as a prognostic biomarker links immunotherapy response in breast cancer. [Abstract]

2023 Apr 3;30(5):e230012. PMID: 36877531
Epigenetics Chromatin

Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation. [Abstract]

2023 Apr 19;16(1):11. PMID: 37076890
Front Mol Neurosci

Chronic salmon calcitonin exerts an antidepressant effect via modulating the p38 MAPK signaling pathway. [Abstract]

2023 Mar 10:16:1071327. PMID: 36969556
Front Mol Neurosci

The chronification mechanism of orofacial inflammatory pain: Facilitation by GPER1 and microglia in the rostral ventral medulla. [Abstract]

2023 Jan 6:15:1078309. PMID: 36683848
BMC Complement Med Ther

Pharmacokinetics and pharmacodynamics of bioactive compounds in Penyanqing preparation in THP-1 inflammatory cells induced by Lipopolysaccharide. [Abstract]

2022 Dec 6;22(1):323. PMID: 36474249
Front Mol Biosci

Comparative Analysis of Long Non-Coding RNA Expression and Immune Response in Mild and Severe COVID-19. [Abstract]

2022 Apr 27;9:835590. PMID: 35573725
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Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice. [Abstract]

2017 Sep 6:10:287. PMID: 28932185
Front Mol Neurosci

MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors. [Abstract]

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Mol Divers

Unraveling RELA as a potential dioctyl terephthalate-related target regulates M2-like macrophages to induce an immunosuppressive microenvironment in colorectal cancer: a multi-omics data study by experimental validation. [Abstract]

2026 Aug;30(4):6403-6419. PMID: 41966666
FASEB J

2026 Jul 15;40(13):e72098. PMID: 42366857
FASEB J

2026 Jul 31;40(14):e72140. PMID: 42455592
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CPN2 alleviates cryptorchidism by inhibiting the NF-κB pathway and regulating immune responses. [Abstract]

2025 Dec;58(1):2538860. PMID: 40720213
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SAA1 Induces TGF-β1 Secretion by Ovarian Cancer Cells, Leading to M2 Macrophage Polarization and Inhibition of NK Cell Activity. [Abstract]

2025 Nov 30;39(22):e71239. PMID: 41269670
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Macrophage WTAP Deficiency Protects Atherosclerosis by Improving Macrophage Apoptosis in an m6A-Independent Manner. [Abstract]

2025 Nov 15;39(21):e71182. PMID: 41148185
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Colorectal cancer cell-derived extracellular vesicles trigger macrophage production of IL6 through activating STING signaling to drive metastasis. [Abstract]

2025 Mar 31;39(6):e70474. PMID: 40100063
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FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3. [Abstract]

2024 Apr;1871(4):119689. PMID: 38367916
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DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease. [Abstract]

2024 Mar 31;38(6):e23564. PMID: 38522019
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Ixazomib Induces Apoptosis and Suppresses Proliferation in Esophageal Squamous Cell Carcinoma through Activation of the c-Myc/NOXA Pathway. [Abstract]

2022 Jan;380(1):15-25. PMID: 34740946
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2026 Jul 14:177:111595. PMID: 42448069
Fish Shellfish Immunol

Transcription factor networks drive perforin activity in the anti-bacterial immune response of tilapia. [Abstract]

2024 Nov:154:109975. PMID: 39427837
Fish Shellfish Immunol

Inducible IL-2 production and IL-2+ cell expansion are landmark events for T-cell activation of teleost. [Abstract]

2024 May:148:109515. PMID: 38499218
Fish Shellfish Immunol

Nitric oxide synthase regulates coelomocytes apoptosis through the NF-κB signaling pathway in the sea cucumber Apostichopus japonicus. [Abstract]

2023 Oct:141:109027. PMID: 37633344
Fish Shellfish Immunol

The flagellin of Vibrio parahaemolyticus induces the inflammatory response of Tetraodon nigroviridis through TLR5M. [Abstract]

2022 Jan:120:102-110. PMID: 34737057
Clin Immunol

2026 Jul 6:287:110745. PMID: 42409229
Clin Immunol

PLK2 facilitates Mycobacterium tuberculosis clearance via p38 MAPK-mediated ROS production. [Abstract]

2026 Jun:285:110705. PMID: 41962814
J Virol

Repression of EEF1D by KSHV RTA promotes viral lytic reactivation. [Abstract]

2026 Apr 21;100(4):e0179325. PMID: 41805193
J Virol

The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway. [Abstract]

2026 Mar 24;100(3):e0195225. PMID: 41631827
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Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles. [Abstract]

2026 Jan 20:111182. PMID: 41570990
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UBE2I promotes immune infiltration and tumor progression in thyroid cancer and modulates hnRNPA2B1 SUMOylation. [Abstract]

2025 Dec 20;302(2):111091. PMID: 41429355
Microbiol Spectr

A novel anti- Toxoplasma peptide suppresses parasite invasion and rescues host autophagic defenses. [Abstract]

2025 Dec 29:e0221825. PMID: 41459975
Microbiol Spectr

miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14. [Abstract]

2025 Aug 5;13(8):e0018825. PMID: 40662581
BMC Cancer

Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes. [Abstract]

2025 Jul 31;25(1):1250. PMID: 40745589
J Antimicrob Chemother

The two-component sensor factor envZ influences antibiotic resistance and virulence in the evolutionary dynamics of multidrug-resistant Salmonella enteritidis causing multisite invasive infections. [Abstract]

2024 Dec 2;79(12):3254-3263. PMID: 39365636
Funct Integr Genomics

Peripheral and central immune features in insomnia: Integrative bulk and single-cell transcriptomic analyses reveal core hub genes and candidate compounds. [Abstract]

2026 Jun 10;26(1):130. PMID: 42265520
ACS Pharmacol Transl Sci

Proviral Integration Site for Moloney Murine Leukemia Virus 2 Suppresses Fibronectin 1 to Drive Adhesion Loss and Epithelial-Mesenchymal Transition in Multiple Myeloma. [Abstract]

2025 Oct 27;8(11):3835-3843. PMID: 41262587
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Trans-Coumaryl acetate mediates GRK5/NF-κB/Nrf2 signaling axis to ameliorate septic acute kidney injury. [Abstract]

2025 Sep 4;19(3):e70044. PMID: 40917114
Regen Ther

PPARA ameliorates sepsis-induced myocardial injury via promoting macrophage M2 polarization by interacting with DUSP1. [Abstract]

2024 May 18:26:33-41. PMID: 38798745
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Clathrin-mediated endocytosis is essential for the selective degradation of maternal membrane proteins and preimplantation development. [Abstract]

2021 Jul 15;148(14):dev199461. PMID: 34269385
J Immunol

The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages. [Abstract]

2021 Mar 1;206(5):963-977. PMID: 33495238
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Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats. [Abstract]

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2026 Apr 11;140:107290.
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2026 Jul 13:116:103518. PMID: 42442637
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The correlation between Omentin-1 levels and Th17/Treg imbalance in patients with periodontitis (Stage Ⅱ/Ⅲ, Grade B/C) and its diagnostic value. [Abstract]

2026 Jun 22. PMID: 42332681
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The Interaction Between Echinococcus multilocularis Calreticulin S-Domain and Human Complement C1q Inhibits C1q-Dependent Immune Functions. [Abstract]

2026 Apr 16;15(4):427. PMID: 42075754
Neurotoxicology

Microglia as a key mediator in rosuvastatin-associated cognitive impairment. [Abstract]

2026 Mar:113:103405. PMID: 41690424
J Orthop Surg Res

RRM2 contributes to pathogenic phenotype of fibroblast-like synoviocytes by activating NF-κB signaling and inhibiting ferroptosis in rheumatoid arthritis. [Abstract]

2025 Nov 7;20(1):976. PMID: 41204303
Metab Brain Dis

β-Caryophyllene modulates the JAK2/STAT3 signaling pathway to downregulate neutrophil extracellular traps and alleviate cerebral ischemia-reperfusion injury. [Abstract]

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Chemoproteomics Reveals FAM114A2 as a Functional Target of Wikstroelide E for Reversal of HIV-1 Latency. [Abstract]

2025 Oct 23. PMID: 41131870
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LncRNA MEG3 Suppresses Prostate Cancer Progression by Mediating Macrophage Polarization via the miR-148a-3p/ARRDC3 Signaling Axis. [Abstract]

2025 Apr 3;46(2):bgaf009. PMID: 40036590
BMC Oral Health

Investigation of the mechanism of baicalein in the treatment of periodontitis based on network pharmacology, molecular docking and experimental validation. [Abstract]

2024 Aug 23;24(1):987. PMID: 39180042
Carcinogenesis

Copine 1 predicts poor clinical outcomes by promoting M2 macrophage activation in ovarian cancer. [Abstract]

2023 Dec 15;44(10-11):748-759. PMID: 37747823
Endocrinology

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2. [Abstract]

2022 Dec 19;164(2):bqac210. PMID: 36524678
J Bioenerg Biomembr

2026 Jul 30;58(1):42. PMID: 42530694
Mol Immunol

Luteolin inhibits IL-33/ST2L-induced M2 macrophage polarization in endometriosis. [Abstract]

2026 Jul:195:172-185. PMID: 42167049
J Med Virol

Quercetin Interrupts the SIRT3/ROS/NF-κB/SPI1 Feedback Loop to Ameliorate Microglia-Mediated HIV-1 Tat Neurotoxicity. [Abstract]

2026 Apr;98(4):e70906. PMID: 41964421
Pathol Res Pract

DDB2 promotes epithelial-mesenchymal transition through activating NF-κB pathway in glioma. [Abstract]

2026 Mar:279:156368. PMID: 41570727
Kidney Dis (Basel)

Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis. [Abstract]

2025 May 9;11(1):450-468. PMID: 40606676
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Antiviral Activity of the MEK1/2 Inhibitor Trametinib Against Lymphocytic Choriomeningitis Virus. [Abstract]

2025 Mar;97(3):e70267. PMID: 40008425
Pathol Res Pract

SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization. [Abstract]

2024 Oct:262:155544. PMID: 39197215
Parasit Vectors

Clonorchis sinensis granulin promotes malignant transformation of human intrahepatic biliary epithelial cells through interaction with M2 macrophages via regulation of STAT3 phosphorylation and the MEK/ERK pathway. [Abstract]

2023 Apr 24;16(1):139. PMID: 37095578
Mol Immunol

Naringenin inhibits pro‑inflammatory cytokine production in macrophages through inducing MT1G to suppress the activation of NF‑κB. [Abstract]

2021 Sep:137:155-162. PMID: 34252709
J Med Virol

Apigenin suppresses influenza A virus-induced RIG-I activation and viral replication. [Abstract]

2020 Dec;92(12):3057-3066. PMID: 32776519
Mol Immunol

mTORC1 signaling pathway regulates macrophages in choroidal neovascularization. [Abstract]

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Curr Pharm Anal

2026 Jul 4;22(6):486-494.
J Diabetes Investig

Hypoxia-preconditioned adipose-derived mesenchymal stem cells-derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5-mediated inactivation of TLR4/NF-κB/NLRP3 inflammatory signaling. [Abstract]

2026 Jun 8. PMID: 42257551
J Biochem Mol Toxicol

UCP2 in Glioblastoma Cells Regulates Mitochondrial Metabolic Reprogramming to Mediate Immunophenotypic Repolarization of Tumor-Associated Macrophages and Immunotherapy. [Abstract]

2026 Apr;40(4):e70808. PMID: 41918143
Stem Cells Int

Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF- κ B Pathway. [Abstract]

2025 Dec 17:2025:1891956. PMID: 41497811
Basic Clin Pharmacol Toxicol

Bergaptol Alleviates Oxidative Stress and Inflammation in Intracerebral Haemorrhage Mice via JAK2/STAT3 and NF-κB Pathways, Improving Neurological Function. [Abstract]

2025 Dec;137(6):e70135. PMID: 41139697
PLoS Negl Trop Dis

The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation. [Abstract]

2025 Dec 11;19(12):e0013815. PMID: 41379884
J Biochem Mol Toxicol

FTO-mediated m6A Methylation of KCNAB2 Inhibits Tumor Property of Non-Small Cell Lung Cancer Cells and M2 Macrophage Polarization by Inactivating the PI3K/AKT Pathway. [Abstract]

2025 Apr;39(4):e70232. PMID: 40114527
Genomics

Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis. [Abstract]

2025 Feb 4;117(2):111013. PMID: 39914597
Nanotoxicology

The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile. [Abstract]

2020 Oct;14(8):1137-1155. PMID: 32916084
Toxicol Appl Pharmacol

M1 macrophage mediated increased reactive oxygen species (ROS) influence wound healing via the MAPK signaling in vitro and in vivo. [Abstract]

2019 Mar 1:366:83-95. PMID: 30690042
Appl Biochem Biotechnol

The Transcription Factor SOX6 Regulates Autophagy Levels Through LAMP5 to Inhibit the Development of Pituitary Adenomas. [Abstract]

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J Radiat Res Appl Sci

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Appl Biochem Biotechnol

LAMA1 Promotes Tumor-Associated Macrophages Polarization Towards the M2 Phenotype and Induces Colorectal Cancer. [Abstract]

2026 Feb;198(2):1374-1390. PMID: 41484729
Arch Biochem Biophys

Exosomal miR-4687-5p alleviates silica-induced fibrosis by inhibiting EMT via β-catenin targeting. [Abstract]

2026 Feb:776:110714. PMID: 41443291
Cardiovasc Drugs Ther

High Mobility Group Protein B1 Mediates the Role of the Neutrophil Extracellular Traps in the Progression of Acute Myocardial Infarction. [Abstract]

2026 Jan 24. PMID: 41579229
Exp Cell Res

Neutrophil extracellular traps promote epithelial-mesenchymal transition in COPD via the RAGE/PI3K/AKT pathway. [Abstract]

2025 Dec 24;455(2):114869. PMID: 41453711
Exp Cell Res

Pseudane V alleviates ox-LDL-induced macrophage M1 polarization by inhibiting m6A modification of PPARGC1A. [Abstract]

2025 Nov 25;454(2):114842. PMID: 41297622
Arch Biochem Biophys

NNMT enhances invasive and migratory capacity of keloid fibroblasts and M2 macrophage polarization. [Abstract]

2025 Nov:773:110593. PMID: 40818625
Immun Inflamm Dis

Neutrophil Extracellular Traps Activate Meningeal Fibroblast to Aggravate Subarachnoid Fibrosis in Kaolin-Induced Hydrocephalus in Rats. [Abstract]

2025 Nov;13(11):e70268. PMID: 41236114
Cell Biol Int

HMGB1 promotes M1 polarization of macrophages and induces COPD inflammation. [Abstract]

2025 Jan;49(1):79-91. PMID: 39364689
Mol Carcinog

LAIR1 promotes hepatocellular carcinoma cell metastasis and induces M2-macrophage infiltration through activating AKT-IKKβ-p65 axis. [Abstract]

2024 Sep;63(9):1827-1841. PMID: 39016636
Arch Biochem Biophys

GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. [Abstract]

2024 Sep:759:110102. PMID: 39029644
Arch Biochem Biophys

Antitumor activity of dictamnine against colorectal cancer through induction of ferroptosis and inhibition of M2 macrophage polarization via the MAPK signaling. [Abstract]

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Vaccines

Mafosfamide Boosts GMI-HBVac against HBV via Treg Depletion in HBV-Infected Mice. [Abstract]

2023 May 25;11(6):1026. PMID: 37376415
Exp Cell Res

CTRP9 induces macrophages polarization into M1 phenotype through activating JNK pathway and enhances VSMCs apoptosis in macrophages and VSMCs co-culture system. [Abstract]

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Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene. [Abstract]

2020 Jul 15;687:108375. PMID: 32339486
Diabetes Metab Syndr Obes

Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes. [Abstract]

2019 Nov 4:12:2289-2302. PMID: 31807042
Mol Cell Endocrinol

2026 Nov:621:112874. PMID: 42476336
J Leukoc Biol

2026 Jul 10:qiag093. PMID: 42430657
Arch Microbiol

YY1-activated LINC00926 promotes the survival of mycobacteria and regulates inflammatory response in Mycobacterium tuberculosis-infected macrophages. [Abstract]

2026 Jun 11;208(9):434. PMID: 42274770
J Evid Based Integr Med

"Huanglianjiedu Decoction" Against Pancreatic Adenocarcinoma Proliferation of by Downregulating the PI3K/AKT/mTOR and MAPK/ERK1/2 Signaling Pathways. [Abstract]

2024 Jan-Dec:29:2515690X241291381. PMID: 39410848
Front Oncol

Overexpression of serum HMGB1 and IDO in esophageal squamous cell carcinoma patients: potential clinical auxiliary diagnostic markers and immunotherapeutic targets. [Abstract]

2024 Sep 9:14:1452282. PMID: 39314628
J Neurooncol

FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells. [Abstract]

2024 Sep;169(3):659-670. PMID: 39073688
J Cancer

Immunoreactive Microenvironment Modulator GBP5 Suppresses Ovarian Cancer Progression by Inducing Canonical Pyroptosis. [Abstract]

2024 May 5;15(11):3510-3530. PMID: 38817865
Reproduction

Follistatin-like I promotes endometriosis by increasing proinflammatory factors and promoting angiogenesis. [Abstract]

2021 Dec 30;163(1):57-68. PMID: 34866594
Mol Cell Endocrinol

Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy. [Abstract]

2019 Aug 20:494:110490. PMID: 31207271
Carbohydr Res

Development of specific inhibitors for heparin-binding proteins based on the cobra cardiotoxin structure: an effective synthetic strategy for rationally modified heparin-like disaccharides and a trisaccharide. [Abstract]

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Cell Immunol

Mesenchymal stromal cells relieved systemic lupus erythematosus via CCL2 dependent macrophage polarization. [Abstract]

2025 Dec:418:105046. PMID: 41187528
J Cancer Res Clin Oncol

Single-cell RNA sequencing reveals SLC31A1-mediated M2 polarization of macrophages promotes malignant progression in triple-negative breast cancer. [Abstract]

2025 May 14;151(5):163. PMID: 40360897
Breast Cancer Res Treat

A high-risk luminal A dominant breast cancer subtype with increased mobility. [Abstract]

2019 Jun;175(2):459-472. PMID: 30778902
Mol Biol Rep

Overexpression of miR-7641 activates ox-LDL-induced autophagy in macrophages by regulating USP7. [Abstract]

2026 Apr 22;53(1):645. PMID: 42018035
IUBMB Life

OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling. [Abstract]

2026 Mar;78(3):e70094. PMID: 41853919
Animals (Basel)

Neutrophil Extracellular Traps Promote Urolithiasis Formation in Dogs: A Preliminary Study. [Abstract]

2026 Mar 17;16(6):942. PMID: 41897919
Food Chem Toxicol

Lysosomal dependent transcytosis of polystyrene nanoplastics within macrophages. [Abstract]

2025 Dec:206:115771. PMID: 41038372
Mol Biol Rep

Inhibition of ACSL6 ameliorates atherosclerosis by suppressing macrophage ferroptosis via the Nrf2 pathway. [Abstract]

2025 Nov 6;53(1):53. PMID: 41196445
Mol Biotechnol

Unraveling the Molecular Landscape of Neutrophil Extracellular Traps in Severe Asthma: Identification of Biomarkers and Molecular Clusters. [Abstract]

2025 May;67(5):1852-1866. PMID: 38801616
Mol Biol Rep

Study on the mechanism of heterogeneous tumor-associated macrophages in three subtypes of breast cancer through the integration of single-cell RNA sequencing and in vitro experiments. [Abstract]

2024 Jun 1;51(1):720. PMID: 38824268
Mol Biotechnol

Tumor Cell-Derived Exosomal miR-191-5p Activates M2-Subtype Macrophages Through SOCS3 to Facilitate Breast Cancer. [Abstract]

2024 May;66(5):1314-1325. PMID: 38270757
Immunol Lett

Autophagy and LC3-associated phagocytosis contribute negatively to the killing capability of THP-1-derived macrophages against Candida albicans at the mid-stage. [Abstract]

2023 Nov:263:25-32. PMID: 37717912
Food Chem Toxicol

Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy. [Abstract]

2022 Oct:168:113354. PMID: 35952824
Immunopharmacol Immunotoxicol

2026 Jul 8:1-17. PMID: 42421290
Placenta

2026 Jul 1:182:217-228. PMID: 42391936
Immunobiology

Chronic stress promotes colorectal cancer progression by inducing M2 macrophage polarization and activating the CCL2-CCR2 axis. [Abstract]

2026 Jun 25;231(4):153211. PMID: 42372631
Tissue Cell

Silencing of SOX4 prevents endothelial injury from ox-LDL stimulation by inhibiting NF-κB pathway and ferroptosis. [Abstract]

2026 Feb:98:103199. PMID: 41166996
Immunobiology

ZBP1 aggravates acute lung injury in mice by promoting the macrophage inflammatory phenotype. [Abstract]

2025 Dec 31;231(1):153154. PMID: 41496195
Tissue Cell

Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD. [Abstract]

2025 Apr:93:102645. PMID: 39671756
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Identification of novel anti-leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach. [Abstract]

2025 Feb;599(3):367-380. PMID: 39266470
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β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β. [Abstract]

2025 Feb 28;25(1):97. PMID: 40022030
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2024 Dec:91:102580. PMID: 39396437
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Immunopharmacol Immunotoxicol

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Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta. [Abstract]

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Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1 β and IL-18 in the Septic Response. [Abstract]

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PLoS One

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2026 Apr 25. PMID: 42032376
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The Role of Talaromyces Marneffei Binding To CD86 in the CD86-CTLA4 Regulatory Pathway. [Abstract]

2025 Dec 27;83(2):100. PMID: 41460255
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ODC1 loss upon KLF6 upregulation promotes macrophage pyroptosis and acute kidney injury in sepsis. [Abstract]

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METTL14 knockdown augmented the polarization of M2-like macrophages to promote acute myeloid leukemia progression. [Abstract]

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Reprod Sci

Targeting Decidual Macrophage Polarization through JNK Signaling Pathway Inhibition Alleviates Adverse Pregnancy Outcomes in Early Spontaneous Abortion. [Abstract]

2025 Jul;32(7):2233-2243. PMID: 40550988
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Tumor-associated macrophages derived exosomal circPLK1 promotes resistance to EGFR inhibitor osimertinib in non-small cell lung cancer. [Abstract]

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Biomol Biomed

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Cytotechnology

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Anticancer Drugs

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Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 100 mg/mL (162.12 mM; Need ultrasonic)

DMSO : 25 mg/mL (40.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6212 mL

8.1060 mL

16.2119 mL

5 mM

0.3242 mL

1.6212 mL

3.2424 mL

10 mM

0.1621 mL

0.8106 mL

1.6212 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (4.05 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 5

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (4.05 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 6

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

All Signal Pathway Related

Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
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Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sergio E. Alvarez, et al. Autocrine and paracrine roles of sphingosine-1-phosphate. TRENDS in Endocrinology and Metabolism Vol.18 No.8

[2]. Zhang T, et al. MPTP-Induced Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors. Front Mol Neurosci. 2017 Aug 7;10:247. [Content Brief]

[3]. Schwende H, et al. Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3. J Leukoc Biol. 1996;59(4):555-561. [Content Brief]

[4]. Mugami S, et al. Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. Mol Cell Endocrinol. 2017 Jan 5;439:141-154. [Content Brief]

[5]. Starr T, et al. The phorbol 12-myristate-13-acetate differentiation protocol is critical to the interaction of THP-1 macrophages with Salmonella Typhimurium. PLoS One. 2018;13(3):e0193601. Published 2018 Mar 14. [Content Brief]

[6]. Hou S, et al. Mechanism of Mitochondrial Connexin43's Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci. 2016 May 5;17(5). pii: E679. [Content Brief]

[7]. Heng-Ching Wen, et al. PMA inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1. Sci Rep. 2018 Nov 2;8(1):16247. [Content Brief]

[8]. Silván AM, et al. Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA-induced mouse ear oedema. Inflamm Res. 1996 Jun;45(6):289-92. [Content Brief]

[9]. Kaur G, et al. Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria. J Ethnopharmacol. 2004 Feb;90(2-3):285-92. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	1.6212 mL	8.1060 mL	16.2119 mL	40.5298 mL
	5 mM	0.3242 mL	1.6212 mL	3.2424 mL	8.1060 mL
	10 mM	0.1621 mL	0.8106 mL	1.6212 mL	4.0530 mL
	15 mM	0.1081 mL	0.5404 mL	1.0808 mL	2.7020 mL
	20 mM	0.0811 mL	0.4053 mL	0.8106 mL	2.0265 mL
	25 mM	0.0648 mL	0.3242 mL	0.6485 mL	1.6212 mL
	30 mM	0.0540 mL	0.2702 mL	0.5404 mL	1.3510 mL
	40 mM	0.0405 mL	0.2026 mL	0.4053 mL	1.0132 mL
Ethanol	50 mM	0.0324 mL	0.1621 mL	0.3242 mL	0.8106 mL
	60 mM	0.0270 mL	0.1351 mL	0.2702 mL	0.6755 mL
	80 mM	0.0203 mL	0.1013 mL	0.2026 mL	0.5066 mL
	100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.4053 mL

Bioz

Keywords

Phorbol 12-myristate 13-acetate

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Phorbol 12-myristate 13-acetate

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