Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Parasite Related Products (2569)
Related Products (2569)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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Antileishmanial agent-21
0 ImagesCat. No.: HY-155845Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM.
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Deoxycaesaldekarin C
0 ImagesDeoxycaesaldekarin C (Methyl vouacapenate) is a naturally occurring, orally active cassane furanoditerpene with antibacterial, antioxidant, antiplasmodial, and analgesic effects. Deoxycaesaldekarin C inhibits bacterial growth and lipid peroxidation, and scavenges free radicals. Deoxycaesaldekarin C exhibits weak antiplasmodial activity and shows analgesic activity in mouse in vivo models. Deoxycaesaldekarin C can be used in research related to pain, bacterial infections, and Plasmodium infections.
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Sterekunthal B
0 ImagesCat. No.: HY-N20619CAS No.: 475673-78-0Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research.
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Diclazuril sodium
0 ImagesCat. No.: HY-B0357BCAS No.: 112209-99-1Synonyms: R-64433 sodiumDiclazuril sodium (R-64433 sodium) is an anticoccidial agent active in preventing parasitic contamination of livestock and poultry feed. Evaluation of the efficacy of Diclazuril sodium in the treatment of Eimeria infection showed poor performance in sustained levels of oocyst excretion compared with controls. Diclazuril sodium has a significant impact on the pathological effects of young animals in clinical applications.
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Tizoxanide-d4 glucuronide
0 ImagesCat. No.: HY-136307STizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum.
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Antiparasitic agent-9
0 ImagesCat. No.: HY-151133CAS No.: 2516237-50-4Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite.
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TCMDC-125457
0 ImagesCat. No.: HY-132931CAS No.: 872113-12-7TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
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Oxyclozanide (Standard)
0 ImagesOxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity.
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Flumethrin (Standard)
0 ImagesCat. No.: HY-107835RCAS No.: 69770-45-2Synonyms: FCR 2769 (Standard)Flumethrin (Standard) (FCR 2769 (Standard)) is the analytical standard of Flumethrin (HY-107835). This product is intended for research and analytical applications. Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer.
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N-Desmethyl clomipramine
0 ImagesN-Desmethyl clomipramine (Desmethylclomipramine; Norclomipramine) is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis.
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Phomoxanthone A
0 ImagesCat. No.: HY-126640CAS No.: 359844-69-2Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively.
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Trypanothione synthetase-IN-1
0 ImagesCat. No.: HY-151148CAS No.: 2355349-41-4Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S.
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Artesunate-d3
0 ImagesCat. No.: HY-N0193SCAS No.: 1316303-44-2Artesunate-d3 is the deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
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BKI 1708
0 ImagesCat. No.: HY-179463CAS No.: 2332840-70-5BKI 1708 is a potent and orally active calcium-dependent protein kinase 1 (CDPK1) inhibitor (IC50 = 0.7 nM). BKI 1708 exhibits potent activity against Neospora (IC50 = 481 nM) and Toxoplasma (IC50 = 122 nM). BKI-1708 induces the formation of multinucleated complexes. BKI-1708 efficiently inhibits vertical transmission of both parasites and increases pup survival in mice.
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(4S)-Anthelvencin
0 ImagesCat. No.: HY-169507CAS No.: 58616-25-4(4S)-Anthelvencin is a pyrrolamide metabolite with moderate antibacterial and anthelmintic activities.
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Antimalarial agent 63
0 ImagesCat. No.: HY-184181CAS No.: 1596337-67-5Antimalarial agent 63 is an inhibitor of Plasmodium falciparum. Antimalarial agent 63 exhibits inhibitory activity against field isolates of Plasmodium falciparum and Plasmodium vivax. Antimalarial agent 63 shows an antagonistic interaction when used in combination with Proguanil (HY-B0806) against Plasmodium falciparum. Antimalarial agent 63 has low cytotoxicity to hepatocytes and a high selectivity index. Antimalarial agent 63 can be used in the research of malaria.
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Antiparasitic agent-43
0 ImagesCat. No.: HY-184376CAS No.: 2095562-44-8Antiparasitic agent-43 is a pyrazine derivative and a Plasmodium falciparum inhibitor with in vitro and in vivo antimalarial activity. It inhibits the growth of P. falciparum in vitro and can be used in research related to malaria.
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Cabraleahydroxylactone
0 ImagesCat. No.: HY-N29777CAS No.: 35833-69-3Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis.
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TbPTR1 inhibitor 1
0 ImagesCat. No.: HY-147940CAS No.: 2499713-65-2TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM).
