Art. -Nr.: HY-B0223

Albendazole

(Synonyms: SKF-62979)

8 Cited Publications

Kundenbewertung

Based on 8 publication(s) in Google Scholar

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells.

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Reinheit: 99.05%
CAS. Nr.: 54965-21-8
Formel: C₁₂H₁₅N₃O₂S
Molecular Weight:265.33

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

Albendazole Chemical Structure

CAS. Nr.: 54965-21-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (8)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

parasites, tubulin^[1]^[2].
HIF-1α, VEGF^[3].

Alle Parasite Isoform-spezifische Produkte anzeigen :

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3M	EC₅₀	1.15 μM Compound: Albendazole	Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay	[PMID: 29288939]

In Vitro

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner^[1].
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle^[1].
Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner^[2].
Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells^[2].
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

SKHEP-1 cells
Concentration:

100, 500, 1000 nM
Incubation Time:

1, 3, or 5 days
Result:

Inhibited cell proliferation in a dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

SKHEP-1 HCC cells
Concentration:

100, 250, 500, 1000 nM
Incubation Time:

3 days
Result:

Showed dose-dependent effect on the cell cycle kinetics.

Apoptosis Analysis^[2]

Cell Line:

HCT-15, HCT-1 16, HT29, SW480 cells
Concentration:

5 µM
Incubation Time:

24, 36 h
Result:

Promoted apoptosis in colon cancer cells.

Cell Autophagy Assay^[2]

Cell Line:

HCT-15, HCT-1 16, HT29, SW480 cells
Concentration:

5 µM
Incubation Time:

24, 36 h
Result:

Induced autophagy in colon cancer cells.

Western Blot Analysis^[2]

Cell Line:

HCT-15, HCT-1 16, HT29, SW480 cells
Concentration:

5 µM
Incubation Time:

12, 24, 36 h
Result:

Induced apoptosis-related protein (PARP, caspase-3) and autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in a time-dependent manner.
Increased phosphorylation of different MAPKs (AMPK, ERK, JNK, p38) and ULK1 protein in a time dependent manner, and up-regulated the activation of different MAPKs.
Caused the activation of both MAPK and AMPK pathways.

Western Blot Analysis^[3]

Cell Line:

A549 cells
Concentration:

500 nM
Incubation Time:

24 h
Result:

Inhibited hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.

In Vivo

Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice^[4].
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/c mice (10-week-age; Echinococcus granulosus infection model)^[4].
Dosage:

10 mg/kg
Administration:

Oral gavage; once a day for 30 days.
Result:

Reduced Echinococcus granulosus cyst weights.

Animal Model:

Male BALB/c Nu/Nu mice (6 to 10-week-old; inoculated subcutaneously with SKHEP-1)^[1].
Dosage:

50, 150, 300 mg/kg
Administration:

Oral administration; per day in two divided dose for 20 days.
Result:

Profoundly suppressed tumor growth in vivo.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 54965-21-8
Appearance Solid
Molecular Weight 265.33
Formel C₁₂H₁₅N₃O₂S
Color White to off-white
SMILES

O=C(OC)NC1=NC2=CC=C(SCCC)C=C2N1
Synonyms

SKF-62979
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (8)

All Flow CytometryCell Proliferation/Viability AssayIn Vivo Efficacy StudyWB

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Journal Impact Factor

ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Commun Biol

Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. [Abstract]

2024 Jan 24;7(1):123. PMID: 38267545

Albendazole purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jan 24;7(1):123. [Abstract]

Albendazole (0.1-1.0 μM; 48 h) treatment increased the CD11b and CD14 expression in a dose dependent manner.

Albendazole purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jan 24;7(1):123. [Abstract]

AML cell lines (Kasumi3, Kasumi6, THP-1, and KG-1) were treated with DMSO, Albendazole (ABZ, 100 nM), or PBZ (100 nM), and the number of cells was counted for 4 days.
Biol Proced Online

Establishment of a mouse lung cancer organoid model and its applications for therapeutic screening. [Abstract]

2025 Jun 16;27(1):21. PMID: 40524168
Toxicol Appl Pharmacol

Albendazole-induced autophagy blockade contributes to elevated apoptosis in cholangiocarcinoma cells through AMPK/mTOR activation. [Abstract]

2022 Nov 1:454:116214. PMID: 36055539

Albendazole purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2022 Nov 1:454:116214. [Abstract]

CCK8 assay of RBE and FRH cells and HIBEPIC (normal human intrahepatic biliary epithelial cells) treated with indicated concentrations of Albendazole (ABZ, 5-20 μM) for 24 h, 48 h and 72 h.

Albendazole purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2022 Nov 1:454:116214. [Abstract]

Albendazole (ABZ, 10 mg/kg; i.p.; once daily) significantly reduced the size, weight, and growth rate of CCA xenografts in treated mice compared with the control group.

Albendazole purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2022 Nov 1:454:116214. [Abstract]

Western blot analysis of autophagy-related proteins expression level in RBE, FRH cells treated with Albendazole (ABZ, 5-10 μM) for 24 h.
Res Sq

2026 Jan 9.
Res Sq

2024 Aug 05.
J Oncol

Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3 β/Tyr216 Accumulation. [Abstract]

2021 Dec 20;2021:4475192. PMID: 34966427

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 20 mg/mL (75.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7689 mL

18.8445 mL

37.6889 mL

5 mM

0.7538 mL

3.7689 mL

7.5378 mL

10 mM

0.3769 mL

1.8844 mL

3.7689 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2 mg/mL (7.54 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2 mg/mL (7.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 3.33 mg/mL (12.55 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (623 KB)
- English - EN (623 KB)
- Français - FR (623 KB)
- Deutsch - DE (623 KB)
- Norwegian - NO (623 KB)
- Español - ES (623 KB)
- Swedish - SV (623 KB)
- Italian - IT (623 KB)
- Korean - KR (623 KB)
- Portuguese - PT (623 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pourgholami MH, et al. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole. Cancer Lett. 2001 Apr 10;165(1):43-9. [Content Brief]

[2]. Jung YY, et al. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Biochimie. 2022 Jul;198:155-166. [Content Brief]

[3]. Zhou F, et al. Albendazole inhibits HIF-1α-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 2017 Apr;428(1-2):171-178. [Content Brief]

[4]. Vural G, et al. Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice. Parasitology. 2020 Nov;147(13):1425-1432. [Content Brief]

[5]. Li L, et al. Determination of albendazole and metabolites in silkworm Bombyx mori hemolymph by ultrafast liquid chromatography tandem triple quadrupole mass spectrometry. PLoS One. 2014 Sep 25;9(9):e105637. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7689 mL	18.8445 mL	37.6889 mL	94.2223 mL
	5 mM	0.7538 mL	3.7689 mL	7.5378 mL	18.8445 mL
	10 mM	0.3769 mL	1.8844 mL	3.7689 mL	9.4222 mL
	15 mM	0.2513 mL	1.2563 mL	2.5126 mL	6.2815 mL
	20 mM	0.1884 mL	0.9422 mL	1.8844 mL	4.7111 mL
	25 mM	0.1508 mL	0.7538 mL	1.5076 mL	3.7689 mL
	30 mM	0.1256 mL	0.6281 mL	1.2563 mL	3.1407 mL
	40 mM	0.0942 mL	0.4711 mL	0.9422 mL	2.3556 mL
	50 mM	0.0754 mL	0.3769 mL	0.7538 mL	1.8844 mL
	60 mM	0.0628 mL	0.3141 mL	0.6281 mL	1.5704 mL

Albendazole

8 Cited Publications

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Albendazole

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

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Publications Citing Use of MedChemExpress (MCE) Albendazole