DNH28
DNH28 is a potent NF-κB and MAPK inhibitor with an IC50 of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and Cleaved-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC).
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- Formel: C23H24ClF3N2O
- Molecular Weight:436.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Caspase 3 |
Bax |
Bcl-2 |
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DNH28 (Compound 28) exhibits lower toxicity toward THLE-3 cells (IC50 = 18.16 μM)[1].
DNH28 (0.46-1.84 μM, 24 h) inhibits HepG2 cells proliferation by inducing apoptosis and dose-dependently inhibits HepG2 cells in the G2/M phase[1].
DNH28 (0.46-1.84 μM, 24 h) inhibits HepG2 cell migration dose-dependently, and it completely inhibits the migration ability at a concentration of 1.84 μM[1].
DNH28 (1.84 μM, 24 h) effectively inhibits the nuclear translocation of p65 induced by TNF-α[1].
DNH28 (0.46-1.84 μM, 24 h) exerts anti-HCC effects by inhibiting the activation of NF-κB and MAPK signaling pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:0.46, 0.92 and 1.84 μM
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Incubation Time:24 h
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Result:Induced apoptosis dose-dependently.
Reached 45.90% of apoptotic cells at 1.84 μM (compared with 14.57% in the control group).
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Cell Line:HepG2 cells
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Concentration:0.46, 0.92 and 1.84 μM
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Incubation Time:24 h
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Result:Reached 76.22% G2/M phase ratio at 1.84 μM.
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Cell Line:HepG2 cells
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Concentration:0.46, 0.92 and 1.84 μM
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Incubation Time:24 h
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Result:Partially suppressed cell migration, whereas at 1.84 μM, the scratch width remained unchanged.
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Cell Line:HepG2 cells
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Concentration:0.46, 0.92 and 1.84 μM
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Incubation Time:24 h
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Result:Increased the expression of pro-apoptotic mRNA levels BAX and C-caspase-3.
Reduced the expression of the anti-apoptotic mRNA levels of BCL-2.
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Cell Line:HepG2 cells
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Concentration:0.46, 0.92 and 1.84 μM
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Incubation Time:24 h
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Result:Exhibited dose-dependent inhibition of the phosphorylation of p65, IκB-α, p38 and ERK.
Significantly down-regulated the activation of the NF-κB and MAPK signaling pathways
Chemical Information
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Molecular Weight 436.90
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Formel C23H24ClF3N2O
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SMILES
CCN1CCN(C2=CC(CC/C(C3=O)=C\C4=CC=C(F)C(F)=C4F)=C3C=C2)CC1.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DNH28 Related Classifications
HY-175037 Related Classifications
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