JAGN1 - jagunal homolog 1 Gene

Also Known as SCN6; GL009

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84522

About JAGN1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,890,610-9,894,349 (from NCBI)

This gene has 2 transcripts (splice variants), 267 orthologues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 15.3), liver (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014]

JAGN1 Products (2)

mRNA	Protein	Name
NM_001363890.1	NP_001350819.1	protein jagunal homolog 1 isoform b
NM_032492.4	NP_115881.3	protein jagunal homolog 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in granulocyte colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	25129144	GOA
involved in neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	25129144	GOA
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	25129144	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25129144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAGN1 Protein Structure

Jagunal

0
100
183 a.a.

Protein Preferred Names	Protein Names
protein jagunal homolog 1

JAGN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JAGN1	Q8N5M9	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CLEC4D	Homo sapiens	Q8WXI8	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CLEC4D	Homo sapiens	Q8WXI8	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CLEC4D	Homo sapiens	Q8WXI8	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CLEC12B	Homo sapiens	Q2HXU8-2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CLEC12B	Homo sapiens	Q2HXU8-2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	NRG1	Homo sapiens	Q02297-10	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	NRG1	Homo sapiens	Q02297-10	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	STOML3	Homo sapiens	Q8TAV4	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	STOML3	Homo sapiens	Q8TAV4	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	STOML3	Homo sapiens	Q8TAV4	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	HTATIP2	Homo sapiens	Q9BUP3-3	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM207	Homo sapiens	Q6UWW9	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM207	Homo sapiens	Q6UWW9	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	SLAMF6	Homo sapiens	Q96DU3	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	SLAMF6	Homo sapiens	Q96DU3	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	SLAMF6	Homo sapiens	Q96DU3	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	FCRL2	Homo sapiens	Q96LA5-2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	FCRL2	Homo sapiens	Q96LA5-2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FCRL2	Homo sapiens	Q96LA5-2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	SMIM19	Homo sapiens	Q96E16	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	SMIM19	Homo sapiens	Q96E16	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	SMIM19	Homo sapiens	Q96E16	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	GP2	Homo sapiens	P55259-4	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	GP2	Homo sapiens	P55259-4	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CLEC7A	Homo sapiens	Q9BXN2	Validated Y2H	25416956
Intra	JAGN1	Q8N5M9	FCRL4	Homo sapiens	Q96PJ5	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FCRL4	Homo sapiens	Q96PJ5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	FCRL4	Homo sapiens	Q96PJ5	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	EDA2R	Homo sapiens	Q9HAV5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	EDA2R	Homo sapiens	Q9HAV5	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	EDA2R	Homo sapiens	Q9HAV5	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	FRMD3	Homo sapiens	A2A2Y4	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	FRMD3	Homo sapiens	A2A2Y4	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	OTULINL	Homo sapiens	Q9NUU6	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	25416956
Intra	JAGN1	Q8N5M9	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	PLPP2	Homo sapiens	O43688	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	PLPP2	Homo sapiens	O43688	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	VTI1B	Homo sapiens	Q9UEU0	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	F11R	Homo sapiens	Q9Y624	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	F11R	Homo sapiens	Q9Y624	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	F11R	Homo sapiens	Q9Y624	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	JAGN1	Q8N5M9	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	KCNA1	Homo sapiens	Q09470	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	KCNA1	Homo sapiens	Q09470	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	VSIG4	Homo sapiens	Q9Y279	Y2H Prey Pooling	32296183
Intra	JAGN1	Q8N5M9	VSIG4	Homo sapiens	Q9Y279	Validated Y2H	32296183
Intra	JAGN1	Q8N5M9	VSIG4	Homo sapiens	Q9Y279	Y2H Array	32296183
Intra	JAGN1	Q8N5M9	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

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Neutropenia, Severe Congenital, 6, Autosomal Recessive	SCN6 Neutropenia, Severe Congenital 6, Autosomal Recessive Severe Congenital Neutropenia 6, Autosomal Recessive Neutropenia, Severe Congenital, Type 6, Autosomal Recessive
Severe Congenital Neutropenia 6	Autosomal Recessive Severe Congenital Neutropenia Due To Jagn1 Deficiency Scn6
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Neutropenia	Leukopenia
Severe Congenital Neutropenia 3	Kostmann Syndrome Infantile Agranulocytosis Kostmann Disease Scn3 Severe Congenital Neutropenia Type 3
Autosomal Dominant Severe Congenital Neutropenia	Severe Congenital Neutropenia Autosomal Dominant Neutropenia, Congenital, Severe, Autosomal Dominant
Severe Congenital Neutropenia 5	Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome Vps45 Deficiency Scn5
Severe Congenital Neutropenia 7	Autosomal Recessive Severe Congenital Neutropenia Due To Csf3r Deficiency Scn7
Cyclic Neutropenia	Cyclic Hematopoiesis Cyclical Neutropenia Neutropenia Cyclic Cyclic Hematopoesis Neutropenia, Cyclic Cyclic Agranulocytosis Neutropenia, Periodic Cyclic Leucopenia Periodic Neutropenia Cyclic Haematopoiesis CH Hematopoiesis, Cyclic Neutropenia, Cyclical
Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio Type PN Clericuzio Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia, Clericuzio-Type Clericuzio-Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia Clericuzio Type Immune-Deficient Poikiloderma Clericuzio-Type Poikiloderma Neutropenia Syndrome Poikiloderma With Neutropenia Clericuzio-Type Poikiloderma, With Neutropenia
Cohen Syndrome	Pepper Syndrome COH1 Hypotonia, Obesity, And Prominent Incisors Coh Chs1, Formerly Norio Syndrome Obesity-Hypotonia Syndrome Prominent Incisors-Obesity-Hypotonia Syndrome Chs1 Hypotonia-Obesity-Prominent Incisors Stage 4s Neuroblastoma
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07014	JAGN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	JAGN1	MGD	MGI:1915017
Canis familiaris	JAGN1	VGNC	VGNC:42174
Bos taurus	JAGN1	VGNC	VGNC:30363
Rattus norvegicus	JAGN1	RGD	RGD:1565488
Macaca mulatta	JAGN1	VGNC	VGNC:73664
Felis catus	JAGN1	VGNC	VGNC:62998
Others	JAGN1	NCBI