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Cat. No.: HY-N16409

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Berkeleyamide C

Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases.

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CAS No.: 1019854-23-9
Formule: C₂₂H₂₆N₂O₆
Masse moléculaire:414.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Berkeleyamide C Chemical Structure

CAS No.: 1019854-23-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

MMP-3

Caspase-1

Voir tous les produits spécifiques à Isoform MMP :

Voir tous les produits spécifiques à Isoform Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 7	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27359163]
HeLa	IC₅₀	>50 μM Compound: 7	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27359163]
HL-60	IC₅₀	>50 μM Compound: 7	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27359163]
K562	IC₅₀	>50 μM Compound: 7	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 27359163]

Chemical Information

CAS No. 1019854-23-9
Masse moléculaire 414.45
Formule C₂₂H₂₆N₂O₆
SMILES

CC(O[C@@H](C1=CC=CC=C1)C(N(C=C2C(NC(CC(C)C)=O)=O)CCO)=CC2=O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Penicillium rubrum
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Stierle AA, et al. The berkeleyamides, amides from the acid lake fungus Penicillum rubrum. J Nat Prod. 2008 May;71(5):856-60. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Berkeleyamide C

Voir tous les produits spécifiques à Isoform MMP

Voir tous les produits spécifiques à Isoform Caspase