country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187854

Copy Link Print Information

Chlorotonil A

Chlorotonil A is an orally active Antibacterial and antimalarial agent. Chlorotonil A is isolated from Sorangium cellulosum. Chlorotonil A inhibits the germination of Clostridioides difficile spores into vegetative cells. Chlorotonil A exhibits antibacterial activity against Gram-positive bacteria and gametocytocidal activity against mature Plasmodium falciparum gametocytes. Chlorotonil A reduces parasitemia in the murine Plasmodium berghei model and prevents recurrent C. difficile infection in mice. Chlorotonil A can be used for research on malaria and Clostridioides difficile infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1009813-26-6
Formule: C₂₆H₃₂Cl₂O₄
Masse moléculaire:479.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chlorotonil A Chemical Structure

CAS No.: 1009813-26-6

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[3]

Microbial Metabolite

Voir tous les produits spécifiques à Isoform Antibiotic :

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Voir tous les produits spécifiques à Isoform Parasite :

In Vitro

Parasitic InfectionBacterial Infection

Parasitic Infection

Chlorotonil A exhibits high activity against late-stage Plasmodium falciparum gametocytes in vitro, with an IC₅₀ of 0.030 μM^[1].

Bacterial Infection

Chlorotonil A (6.4 μg/mL-12.5 ng/mL; 24 h) exhibits potent bactericidal antibacterial activity against multiple Clostridioides difficile strains, including strains resistant to Vancomycin (HY-B0671), Metronidazole (HY-B0318), and Fidaxomicin (HY-17580), with MIC/MBC values of 0.4 to 1.6 μg/mL^[3].
Chlorotonil A (0.1 μg/mL and above) inhibits the outgrowth of C. difficile VPI10463 spores into vegetative cells, with complete inhibition observed at concentrations of 0.4 μg/mL and above^[3].

Bacterial Infection

Parasitic Infection

Chlorotonil A exhibits potent antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and potent antiplasmodial activity against Plasmodium falciparum^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

Chlorotonil A (40 mg/kg; p.o.) effectively antagonizes established CDI in mice and prevents recurrent infection, with a survival rate of 66.6%, and 83.3% of surviving mice clear the pathogen^[3].
Chlorotonil A (40 mg/kg; p.o.) maintains colonization resistance against C. difficile in mice, preventing colonization and disease^[3].
Chlorotonil A (2 × 5 mg/kg; intravenous injection) reduces the bacterial burden of Staphylococcus aureus by approximately 4 log units in a mouse thigh infection model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6N SPF mice (female and male, 6-30 weeks old)^[3]
Dosage:

40 mg/kg
Administration:

p.o.; on days 1 and 2; or on day −1 as pre-treatment
Result:

Achieved a final survival rate of 66.6% (6/9 mice).
Cleared C. difficile completely by day 7 in 83.3% of surviving mice (5/6).
Reduced amounts of toxins approximately 100-fold compared with vancomycin-treated mice at day 5.
Resulted in significantly slower onset of disease and minor severity compared with control in the pre-treatment experiment.

Animal Model:

C57BL/6N SPF mice (female and male, 6-30 weeks old)^[3]
Dosage:

40 mg/kg
Administration:

p.o.; single dose
Result:

Did not lead to phenotypic disease.
No vegetative cells or spores were detected in ChA-treated mice.

Animal Model:

Mice^[4]
Dosage:

2 × 5 mg/kg
Administration:

i.v.
Result:

Reduced bacterial burden in the thigh by approximately 4 log.

Related Protocols :

Chemical Information

CAS No. 1009813-26-6
Masse moléculaire 479.44
Formule C₂₆H₃₂Cl₂O₄
SMILES

O=C1C(Cl)(Cl)C([C@H](C)C(O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@]2([H])[C@]1([H])[C@]3([H])[C@H](C)C=C(C)C[C@@]3([H])C=C2)=O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganism
Sorangium cellulosum
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Moyo P, et al. Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?. Pharmaceuticals (Basel, Switzerland). 2020 Sep 17;13(9):251.

[2]. Karcher ML, et al. Construction of a novel reporter strain indicating inhibition of cell wall biosynthesis. Applied microbiology and biotechnology. 2026 Aug 28;110(1):260.

[3]. Bublitz A, et al. The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. [Content Brief]

[4]. Hofer W, et al. Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives. Angewandte Chemie (International ed. in English). 2022 Jul 25;61(30):e202202816.

[5]. Woldearegai T G. Characterization of Plasmodium falciparum mature gametocytes: lifespan, immunogenicity and susceptibility to novel compounds[D]. Dissertation, Tübingen, Universität Tübingen, 2018, 2018.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Chlorotonil A

Voir tous les produits spécifiques à Isoform Antibiotic

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Description

IC50 & Target

In Vitro

In Vivo

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Chlorotonil A Related Classifications

HY-187854 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target