HDAC-IN-43
HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity .
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- CAS No.: 1809163-24-3
- Formule: C22H28N6O4
- Masse moléculaire:440.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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HDAC6 24 nM (IC50) |
HDAC3 45 nM (IC50) |
HDAC1 82 nM (IC50) |
HDAC10 182 nM (IC50) |
HDAC2 358 nM (IC50) |
HDAC8 1441 nM (IC50) |
HDAC11 9061 nM (IC50) |
HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1]
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Concentration:0.22-1.42 μM
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Incubation Time:72 h
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Result:showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1].
Chemical Information
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CAS No. 1809163-24-3
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Masse moléculaire 440.50
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Formule C22H28N6O4
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SMILES
O=C(NO)CCCOC1=CC=CC(C2=C3N=CN(C(C)C)C3=NC(N4CCOCC4)=N2)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-43 Related Classifications
HY-147966 Related Classifications
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