CDK2/TrkA-IN-1
CDK2/TrkA-IN-1 is a CDK2/TrkA inhibitor with IC50 values of 6.81 μM and 10.13 μM, respectively. CDK2/TrkA-IN-1 modulates cell cycle and cell proliferation signaling pathways and acts on EGFR and VEGFR-2 tyrosine kinases. CDK2/TrkA-IN-1 exhibits antiproliferative activity against MCF‑7, HCT‑116, and A‑549 tumor cells, with low toxicity to normal human lung fibroblasts. CDK2/TrkA-IN-1 induces cell cycle arrest and apoptosis in tumor cells. CDK2/TrkA-IN-1 can be used for research on breast cancer, colon cancer, and lung cancer.
For research use only. We do not sell to patients.
- Formula: C15H13ClF3N3S
- Molecular Weight:359.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CDK2 6.81 μM (IC50) |
TrkA 10.13 μM (IC50) |
VEGFR2 |
EGFR |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.05 μM
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Antiproliferative activity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
Antiproliferative activity against human MCF-7 breast cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
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42800165 |
| HCT-116 | IC50 |
0.02 μM
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Antiproliferative activity against human HCT-116 colon cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
Antiproliferative activity against human HCT-116 colon cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
|
42800165 |
| A549 | IC50 |
0.04 μM
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Antiproliferative activity against human A-549 lung cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
Antiproliferative activity against human A-549 lung cancer cells assessed as viability reduction by MTT assay with IC50 derived from dose-response curves.
|
42800165 |
| WI-38 | IC50 |
27.65 μM
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Antiproliferative activity against normal human WI-38 lung fibroblast cells assessed as viability reduction.
Antiproliferative activity against normal human WI-38 lung fibroblast cells assessed as viability reduction.
|
42800165 |
In Vitro
CDK2/TrkA-IN-1 has IC50 values of 0.05, 0.02, and 0.04 µM against MCF-7, HCT-116, and A-549, respectively; its IC50 in WI-38 normal human lung fibroblasts is 27.65 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- Protocol for Cell Cycle
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Apoptosis Solutions
- MTT Cell Proliferation Assay
Chemical Information
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Molecular Weight 359.80
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Formula C15H13ClF3N3S
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SMILES
C=CCNC1=NC(SCC2=CC=C(Cl)C=C2)=NC(C(F)(F)F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2/TrkA-IN-1 Related Classifications
HY-190642 Related Classifications
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Keywords
- CDK2/TrkA-IN-1
- CDK
- Trk Receptor
- EGFR
- VEGFR
- Apoptosis
- Cyclin dependent kinase
- Tropomyosin related kinase receptor
- Epidermal growth factor receptor
- ErbB-1
- HER1
- Vascular endothelial growth factor receptor
- CDK2
- TrkA
- VEGFR-2
- apoptosis
- breast cancer
- cell-cycle arrest
- cyclin-dependent kinase
- tropomyosin receptor kinase
- tyrosine kinases
- Inhibitor
- inhibitor
- inhibit