Art. -Nr.: HY-N2907

Atranorin

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Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions.

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Reinheit: 99.68%
CAS. Nr.: 479-20-9
Formel: C₁₉H₁₈O₈
Molecular Weight:374.34

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Atranorin Chemical Structure

CAS. Nr.: 479-20-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	>5 μM Compound: 4	Antiproliferative activity against human HaCaT cells Antiproliferative activity against human HaCaT cells	[PMID: 10395495]
PMNL	IC₅₀	6 μM Compound: 4	Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells	[PMID: 10395494]

In Vitro

Atranorin (0.01-10 μg/mL; 3 h) protects SH-SY5Y cells from H₂O₂-induced cytotoxicity^[1].
Atranorin (24 h) inhibits the expression of PD-L1 and TIM-3 in THP-1, KG-1 and Mono-Mac-1 cells, with the mechanism related to AKT pathway inhibition^[2].
Atranorin (0-10 μg/mL; 24-72 h) suppresses the migration and invasion of A549 cells. The mechanism involves the inhibition of AP-1, Wnt, STAT pathways and RhoGTPase activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atranorin (10 mg/kg; intraperitoneal injection; once every 3 days; 2 weeks) exhibits antitumor activity in a mouse lung cancer model^[3].
Atranorin (1-5%; topical application as an ointment; once daily; 3-21 days) promotes wound healing in a rat excisional wound model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice aged 8 weeks old treated LLC cells^[3]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection; once every 3 days; 2 weeks
Result:

Significantly reduced tumor volume, tumor weight, and nuclear Ki-67 immunoreactivity.
Downregulated target genes (e.g., KITENIN, STAT, c-myc) in tumor tissues.

Animal Model:

Male Wistar rats (220-260 g) with full-thickness excisional wounds created by an 8 mm biopsy punch on the back^[4]
Dosage:

1% and 5% in ointment form
Administration:

Topical application as an ointment; once daily; 3, 7, 14 and 21 days
Result:

Reduced wound areas significantly on days 3, 7, and 14 (particularly with 5% atranorin).
Induced earlier granulation tissue formation with increased fibroblastic and vascular components.
Improved collagen deposition and organization (with more type I collagen and dense interlaced arrangement in the 5% group).
Modulated myofibroblasts differentiation (reduced early myofibroblasts in the 5% group and promoted timely apoptosis by day 21).

Chemical Information

CAS. Nr. 479-20-9
Appearance Solid
Molecular Weight 374.34
Formel C₁₉H₁₈O₈
Color White to off-white
SMILES

O=C(OC1=CC(C)=C(C(OC)=O)C(O)=C1C)C2=C(C)C=C(O)C(C=O)=C2O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 12.5 mg/mL (33.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6714 mL

13.3568 mL

26.7137 mL

5 mM

0.5343 mL

2.6714 mL

5.3427 mL

10 mM

0.2671 mL

1.3357 mL

2.6714 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Melo MG, et al. Redox properties and cytoprotective actions of atranorin, a lichen secondary metabolite. Toxicol In Vitro. 2011 Mar;25(2):462-8. [Content Brief]

[2]. Semenov K N, et al. Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome. Journal of Molecular Liquids, 2024, 413: 125743.

[3]. Zhou R, et al. The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis. Sci Rep. 2017 Aug 15;7(1):8136. [Content Brief]

[4]. Barreto R S S, et al. Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents. Revista Brasileira de Farmacognosia, 2013, 23(2): 310-319.

[5]. Ranković B, et al. The antimicrobial activity of substances derived from the lichens Physcia aipolia, Umbilicaria polyphylla, Parmelia caperata and Hypogymnia physodes. World journal of microbiology and biotechnology, 2008, 24: 1239-1242.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6714 mL	13.3568 mL	26.7137 mL	66.7842 mL
	5 mM	0.5343 mL	2.6714 mL	5.3427 mL	13.3568 mL
	10 mM	0.2671 mL	1.3357 mL	2.6714 mL	6.6784 mL
	15 mM	0.1781 mL	0.8905 mL	1.7809 mL	4.4523 mL
	20 mM	0.1336 mL	0.6678 mL	1.3357 mL	3.3392 mL
	25 mM	0.1069 mL	0.5343 mL	1.0685 mL	2.6714 mL
	30 mM	0.0890 mL	0.4452 mL	0.8905 mL	2.2261 mL

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Atranorin

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