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Art. -Nr.: HY-187854

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Chlorotonil A

Chlorotonil A is an orally active Antibacterial and antimalarial agent. Chlorotonil A is isolated from Sorangium cellulosum. Chlorotonil A inhibits the germination of Clostridioides difficile spores into vegetative cells. Chlorotonil A exhibits antibacterial activity against Gram-positive bacteria and gametocytocidal activity against mature Plasmodium falciparum gametocytes. Chlorotonil A reduces parasitemia in the murine Plasmodium berghei model and prevents recurrent C. difficile infection in mice. Chlorotonil A can be used for research on malaria and Clostridioides difficile infection.

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CAS. Nr.: 1009813-26-6
Formel: C₂₆H₃₂Cl₂O₄
Molecular Weight:479.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chlorotonil A Chemical Structure

CAS. Nr.: 1009813-26-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[3]

Microbial Metabolite

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Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

Parasitic InfectionBacterial Infection

Parasitic Infection

Chlorotonil A exhibits high activity against late-stage Plasmodium falciparum gametocytes in vitro, with an IC₅₀ of 0.030 μM^[1].

Bacterial Infection

Chlorotonil A (6.4 μg/mL-12.5 ng/mL; 24 h) exhibits potent bactericidal antibacterial activity against multiple Clostridioides difficile strains, including strains resistant to Vancomycin (HY-B0671), Metronidazole (HY-B0318), and Fidaxomicin (HY-17580), with MIC/MBC values of 0.4 to 1.6 μg/mL^[3].
Chlorotonil A (0.1 μg/mL and above) inhibits the outgrowth of C. difficile VPI10463 spores into vegetative cells, with complete inhibition observed at concentrations of 0.4 μg/mL and above^[3].

Bacterial Infection

Parasitic Infection

Chlorotonil A exhibits potent antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae, and potent antiplasmodial activity against Plasmodium falciparum^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

Chlorotonil A (40 mg/kg; p.o.) effectively antagonizes established CDI in mice and prevents recurrent infection, with a survival rate of 66.6%, and 83.3% of surviving mice clear the pathogen^[3].
Chlorotonil A (40 mg/kg; p.o.) maintains colonization resistance against C. difficile in mice, preventing colonization and disease^[3].
Chlorotonil A (2 × 5 mg/kg; intravenous injection) reduces the bacterial burden of Staphylococcus aureus by approximately 4 log units in a mouse thigh infection model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6N SPF mice (female and male, 6-30 weeks old)^[3]
Dosage:

40 mg/kg
Administration:

p.o.; on days 1 and 2; or on day −1 as pre-treatment
Result:

Achieved a final survival rate of 66.6% (6/9 mice).
Cleared C. difficile completely by day 7 in 83.3% of surviving mice (5/6).
Reduced amounts of toxins approximately 100-fold compared with vancomycin-treated mice at day 5.
Resulted in significantly slower onset of disease and minor severity compared with control in the pre-treatment experiment.

Animal Model:

C57BL/6N SPF mice (female and male, 6-30 weeks old)^[3]
Dosage:

40 mg/kg
Administration:

p.o.; single dose
Result:

Did not lead to phenotypic disease.
No vegetative cells or spores were detected in ChA-treated mice.

Animal Model:

Mice^[4]
Dosage:

2 × 5 mg/kg
Administration:

i.v.
Result:

Reduced bacterial burden in the thigh by approximately 4 log.

Related Protocols :

Chemical Information

CAS. Nr. 1009813-26-6
Molecular Weight 479.44
Formel C₂₆H₃₂Cl₂O₄
SMILES

O=C1C(Cl)(Cl)C([C@H](C)C(O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@]2([H])[C@]1([H])[C@]3([H])[C@H](C)C=C(C)C[C@@]3([H])C=C2)=O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganism
Sorangium cellulosum
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Moyo P, et al. Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?. Pharmaceuticals (Basel, Switzerland). 2020 Sep 17;13(9):251.

[2]. Karcher ML, et al. Construction of a novel reporter strain indicating inhibition of cell wall biosynthesis. Applied microbiology and biotechnology. 2026 Aug 28;110(1):260.

[3]. Bublitz A, et al. The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. [Content Brief]

[4]. Hofer W, et al. Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives. Angewandte Chemie (International ed. in English). 2022 Jul 25;61(30):e202202816.

[5]. Woldearegai T G. Characterization of Plasmodium falciparum mature gametocytes: lifespan, immunogenicity and susceptibility to novel compounds[D]. Dissertation, Tübingen, Universität Tübingen, 2018, 2018.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chlorotonil A

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Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Parasite Isoform-spezifische Produkte anzeigen

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Beschreibung

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In Vitro

In Vivo

Chemical Information

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Chlorotonil A Related Classifications

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