CST651
CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC50 values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia.
(Pink: Cdk4/cyclin D3 and Cdk4/cyclin D1 and Cdk6/cyclin D2 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440)).
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- CAS. Nr.: 2489241-16-7
- Formel: C56H72FN11O9S
- Molecular Weight:1094.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle PROTACs Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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CDK6 5.1 nM (DC50, In MM.1S cells) |
CDK4 20 nM (DC50, In MM.1S cells) |
VHL |
Chemical Information
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CAS. Nr. 2489241-16-7
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Molecular Weight 1094.30
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Formel C56H72FN11O9S
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SMILES
O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCN(CCOCCOCCOC6=CC(C7=C(C)N=CS7)=CC=C6CNC([C@H]8N(C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)C[C@H](O)C8)=O)CC5)C=N4)C
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Synonyms
PROTAC CDK4/6 degrader 34
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CST651 Related Classifications
HY-134303 Related Classifications
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