ATG5 - autophagy related 5 Gene

Also Known as ASP; APG5; APG5L; hAPG5; SCAR25; APG5-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9474

About ATG5

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:106,184,476-106,325,760 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 11.9), adrenal (RPKM 11.0) and 25 other tissues.

Summary

The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate Antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and Apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

ATG5 Products (5)

mRNA	Protein	Name
NM_001286106.2	NP_001273035.1	autophagy protein 5 isoform a
NM_001286107.2	NP_001273036.1	autophagy protein 5 isoform b precursor
NM_001286108.2	NP_001273037.1	autophagy protein 5 isoform c
NM_001286111.2	NP_001273040.1	autophagy protein 5 isoform d
NM_004849.4	NP_004840.1	autophagy protein 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables Atg8-family ligase activity	IDA IDA: Inferred from direct assay	23202584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9852036	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in aggrephagy	IMP IMP: Inferred from mutant phenotype	22982048	GOA
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	23202584	GOA
involved in autophagy	IGI IGI: Inferred from genetic interaction	28389568	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	26812546	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	25484072	GOA
acts upstream of or within negative regulation of autophagic cell death	IMP IMP: Inferred from mutant phenotype	19273585	GOA
involved in negative regulation of defense response to virus	IDA IDA: Inferred from direct assay	19666601	GOA
involved in positive regulation of viral translation	IDA IDA: Inferred from direct assay	19666601	GOA
involved in regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	22342342	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Atg12-Atg5-Atg16 complex	IPI IPI: Inferred from physical interaction	23202584	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	15292400	GOA
located in membrane	IDA IDA: Inferred from direct assay	23093945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG5 Protein Structure

APG5

0
100
200
275 a.a.

Protein Preferred Names	Protein Names
autophagy protein 5	APG5 autophagy 5-like

ATG5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ATG5	Q9H1Y0	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	ATG10	Homo sapiens	Q9H0Y0	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	ATG10	Homo sapiens	Q9H0Y0	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	FMR1	Homo sapiens	Q8IXW7	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	FMR1	Homo sapiens	Q8IXW7	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	ATG5	Q9H1Y0	MAVS	Homo sapiens	Q7Z434-1	Pull Down	17709747
Intra	ATG5	Q9H1Y0	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	17709747
Intra	ATG5	Q9H1Y0	RIGI	Homo sapiens	O95786-1	Pull Down	17709747
Intra	ATG5	Q9H1Y0	RIGI	Homo sapiens	O95786-1	Anti Tag CoIP	17709747
Intra	ATG5	Q9H1Y0	WDFY3	Homo sapiens	Q8IZQ1	Anti Tag CoIP	20417604
Intra	ATG5	Q9H1Y0	WDFY3	Homo sapiens	Q8IZQ1	Confocal	20417604
Intra	ATG5	Q9H1Y0	WDFY3	Homo sapiens	Q8IZQ1	Y2H	20417604
Intra	ATG5	Q9H1Y0	PSMB11	Homo sapiens	A5LHX3	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	PSMB11	Homo sapiens	A5LHX3	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	CCDC12	Homo sapiens	Q8WUD4	Anti Tag CoIP	20562859
Intra	ATG5	Q9H1Y0	CCDC12	Homo sapiens	Q8WUD4	Anti Tag CoIP	33961781
Intra	ATG5	Q9H1Y0	CCDC12	Homo sapiens	Q8WUD4	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	CCDC12	Homo sapiens	Q8WUD4	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	TECPR1	Homo sapiens	Q7Z6L1	Anti Tag CoIP	20562859
Intra	ATG5	Q9H1Y0	TECPR1	Homo sapiens	Q7Z6L1	Anti Tag CoIP	33961781
Intra	ATG5	Q9H1Y0	TECPR1	Homo sapiens	Q7Z6L1	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	TECPR1	Homo sapiens	Q7Z6L1	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG5	Q9H1Y0	ATG16L1	Homo sapiens	Q676U5	GMS	23202584
Intra	ATG5	Q9H1Y0	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	20562859
Intra	ATG5	Q9H1Y0	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	33961781
Intra	ATG5	Q9H1Y0	ATG16L1	Homo sapiens	Q676U5	Ion Exchange Chrom	23202584
Intra	ATG5	Q9H1Y0	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG5	Q9H1Y0	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	17353931
Intra	ATG5	Q9H1Y0	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	ATG5	Q9H1Y0	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	32296183
Intra	ATG5	Q9H1Y0	TEKT4	Homo sapiens	Q8WW24	Y2H Array	31515488
Intra	ATG5	Q9H1Y0	TEKT4	Homo sapiens	Q8WW24	Y2H Array	32296183
Intra	ATG5	Q9H1Y0	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG5 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7620	ATG5 Protein, Human	Q9H1Y0-1 (M1-D275)	≥ 90%, as determined by reducing SDS-PAGE.

ATG5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80022	ATG5 Antibody (YA599)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Rat, Mouse, Monkey
HY-P80545	ATG5 Antibody (YA615)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80545A	ATG5 Antibody (YA615)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84790	ATG5 Antibody (YA4487)	WB, ICC/IF, FC, ELISA	Human
HY-P84790A	ATG5 Antibody (YA4487)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P85775	ATG5 Antibody (YA5467)	WB, ICC/IF, ELISA	Human, Mouse,
HY-P86397	ATG5 Antibody (YA6089)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86744	ATG5 Antibody (YA6436)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat
HY-P86744A	ATG5 Antibody (YA6436)(PBS only)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 25	SCAR25 Autosomal Recessive Spinocerebellar Ataxia 25 Spinocerebellar Ataxia, Autosomal Recessive, 25
Stomatitis
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Vici Syndrome	Absent Corpus Callosum Cataract Immunodeficiency VICIS Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum Dionisi Vici Sabetta Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome Dionisi-Vici-Sabetta-Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Ciliary Dyskinesia, Primary, 33	Primary Ciliary Dyskinesia 33 CILD33 Ciliary Dyskinesia, Primary, 33, Without Situs Inversus Primary Ciliary Dyskinesia 33 Without Situs Inversus
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Mouth Disease	Mouth Diseases Mouth Disorders
Danon Disease	Pseudoglycogenosis Ii Antopol Disease Glycogen Storage Disease Iib Glycogen Storage Disease Type 2b Glycogen Storage Disease Type Iib Gsd2b Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency Vacuolar Cardiomyopathy And Myopathy X-Linked Vacuolar Cardiomyopathy And Myopathy, X-Linked Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly Gsd2b, Formerly Gsd Iib, Formerly Glycogen Storage Cardiomyopathy Glycogen Storage Disease Limited To The Heart Pseudoglycogenosis 2 X-Linked Vacuolar Cardiomyopathy And Myopathy Lysosomal Glycogen Storage Disease With Normal Acid Maltase Glycogen Storage Disease Due To Lamp-2 Deficiency Gsd Due To Lamp-2 Deficiency Glycogenosis Due To Lamp-2 Deficiency Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity DAND Gsd-Iib
Cerebellar Hypoplasia
Myopathy, X-Linked, With Excessive Autophagy	X-Linked Myopathy With Excessive Autophagy Xmea MEAX Vacuolar Myopathy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Malt Worker'S Lung	Alveolitis Due To Aspergillus Clavatus Malt Worker Lung Malt Workers' Lung Malt-Workers' Lung Malt Fever Malt House Workers' Cough Malt-Workers' Alveolitis Malt-Workers' Lung Disease Alveolitis Due To Aspergillus Fumigatus Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Art. -Nr.	Produktname	Reinheit	Rare Diseases
HY-W018791	Bifendate	99.92%	Unkown
HY-N0538	Xylitol	99.5%	Yes
HY-B0960	Sulfabenzamide	99.68%	Unkown

Pre-clinical Phase

Bioactive Molecules (30)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N3415	Kumatakenin		99.31%	Unkown
HY-N4120	Valechlorine	Inducer	/	Unkown
HY-RS01152	ATG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23989	Atg5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-151914	Antitumor agent-82	Inducer	/	Unkown
HY-157548	Antitumor agent-133	Inducer	/	Unkown
HY-167843	Alborixin		/	Unkown
HY-170594	Antitumor agent-192	Inducer	/	Unkown
HY-173133	Antitumor agent-199		/	Unkown
HY-179052	Apoptosis inducer 50		/	Unkown
HY-183730	4E1RCat 17d	Inhibitor	/	Unkown
HY-183731	ATG5 PPI-IN-1		/	Unkown
HY-183737	ATG5/TECAIR-IN-1	Inhibitor	/	Unkown
HY-183738	4E1RCat 27d		/	Unkown
HY-183807	T1742	Inhibitor	/	Unkown
HY-183826	ATG5 PPI-IN-4	Inhibitor	/	Unkown
HY-183827	ATG5 PPI-IN-5	Inhibitor	/	Unkown
HY-183829	ATG5/TECAIR-IN-3	Inducer	/	Unkown
HY-183833	Autophagy-IN-9	Inhibitor	/	Unkown
HY-183835	Autophagy-IN-10	Inhibitor	/	Unkown
HY-183838	Autophagy-IN-11	Inhibitor	/	Unkown
HY-183848	ATG5/TECAIR-IN-4	Inhibitor	/	Unkown
HY-183867	ATG5 PPI-IN-6	Inhibitor	/	Unkown
HY-184501	UE01		/	Unkown
HY-N13352	Bufothionine		/	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-183732	ATG5 PPI-IN-2	Inhibitor	/	Unkown
HY-183736	Autophagy-IN-12	Inhibitor	/	Unkown
HY-183828	ATG5/TECAIR-IN-2	Inhibitor	/	Unkown
HY-RS17532	Atg5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATG5	VGNC	VGNC:56361
Macaca mulatta	ATG5	VGNC	VGNC:70165
Rattus norvegicus	ATG5	RGD	RGD:1359580
Mus musculus	ATG5	MGD	MGI:1277186
Canis familiaris	ATG5	VGNC	VGNC:38226
Felis catus	ATG5	VGNC	VGNC:67742
Others	ATG5	NCBI