HDAC-IN-51
Based on 1 publication(s) in Google Scholar
HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer.
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- CAS. Nr.: 3026728-28-6
- Formel: C27H24N4O2
- Molecular Weight:436.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-51
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Biologische Aktivität
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HDAC10 0.32 μM (IC50) |
HDAC1 0.353 μM (IC50) |
HDAC2 0.431 μM (IC50) |
HDAC3 0.515 μM (IC50) |
HDAC11 85.4 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.51 μM
Compound: 8d; MC2666
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Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
| HCT-116 | IC50 |
0.32 μM
Compound: 8d; MC2666
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Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
| K562 | IC50 |
0.32 μM
Compound: 8d; MC2666
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Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
HDAC-IN-51 (compound 8d; 1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM for K562, HCT116, and A549 cells, respectively[1].
HDAC-IN-51 (1 and 5 μM; 24 and 48 h; U937 leukaemia cells) arrests cell cycle at the G1 phase[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) induces apoptosis and down-regulates miRNAs with antiapoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p)[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) increases mRNA expression of p21, BAX and BAK, down-regulates cyclin D1 and BCL-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, HCT116, and A549 cells
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Concentration:1 nM-10 μM
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Incubation Time:48 hours
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Result:Inhibited cell growth in cancer cells.
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Cell Line:U937 leukaemia cells
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Concentration:1 and 5 μM
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Incubation Time:24 and 48 hours
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Result:Blocked the cell cycle at the G1 phase in U937 leukaemia cells.
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Cell Line:U937 cells
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Concentration:1 and 5 μM
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Incubation Time:48 hours
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Result:Down-regulates miRNAs with antiapoptotic activity including miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p.
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Cell Line:U937 cells
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Concentration:1 and 5 μM
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Incubation Time:48 hours
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Result:Increased mRNA expression of p21, BAX and BAK and down-regulated cyclin D1 and BCL-2 in a dose-dependent manner.
Chemical Information
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CAS. Nr. 3026728-28-6
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Molecular Weight 436.51
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Formel C27H24N4O2
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SMILES
NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(C(C3=CC=CC=C3)CC4=CC=CC=C4)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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