Ebp - EBP, cholestenol delta-isomerase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117278

Summary

Enables C-8 sterol isomerase activity. Involved in Cholesterol biosynthetic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in MEND syndrome; X-linked chondrodysplasia punctata 2; and chondrodysplasia punctata. Orthologous to human EBP (EBP cholestenol delta-isomerase). [provided by Alliance of Genome Resources, Apr 2022]

Ebp Products (1)

mRNA Protein Name
NM_057137.1 NP_476478.1 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables C-8 sterol isomerase activity IDA
IDA: Inferred from direct assay
11171067 RGD
Biological Process GO Annotation Evidence References Source
involved in cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
11171067 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

  • D8-D7 sterol isomerase

  • cholestenol Delta-isomerase

  • delta(8)-Delta(7) sterol isomerase

  • emopamil binding protein (sterol isomerase)

  • emopamil-binding protein

  • phenylalkylamine Ca2+ antagonist (emopamil) binding protein

  • sterol 8-isomerase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0660 Eicosapentaenoic Acid Activator 98.09% Yes
HY-10466 Daclatasvir Inhibitor 99.57% Unkown
HY-10465 Daclatasvir dihydrochloride Inhibitor 99.82% Unkown
HY-10237 Boceprevir Inhibitor 98.52% Unkown
HY-W011269 Eicosapentaenoic Acid sodium Activator 95.78% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-132607 MTL-CEBPA 95.52% Phase 2
HY-13766 Timcodar Inhibitor 99.66% Phase 2
HY-132168 RMC-5552 Inhibitor 99.94% Phase 1
HY-10062 AZD3409 Inhibitor / Phase 1
HY-157828 DSP-0390 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (82)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110188 BiP inducer X Inhibitor 99.62% Unkown
HY-N4103 Fucosterol Inhibitor 98.27% Unkown
HY-12461 WS6 99.30% Unkown
HY-164561 TASIN-30 99.96% Unkown
HY-116572A TASIN-1 98.09% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-162351 EBP-IN-1 Inhibitor 99.77% Unkown
HY-N1677 2,6-Dimethoxy-1,4-benzoquinone 98.72% Unkown
HY-N6954 Garcinone C 99.51% Unkown
HY-N0777 Isorhamnetin-3-O-glucoside 99.96% Unkown
HY-12462 WS3 98.70% Unkown
HY-132607A MTL-CEBPA sodium 91.62% Unkown
HY-N0656A (+)-Usnic acid 99.64% Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-114519 Helenalin acetate Inhibitor 99.55% Unkown
HY-134334 C/EBPα inducer 1 99.82% Unkown
HY-115590 JP-11646 98.74% Unkown
HY-N14035 Garcinia cambogia extract Activator / Unkown
HY-134333 ICCB280 Activator 98.14% Unkown
HY-143510 RMC-4627 99.20% Unkown
HY-128671 6-​Thioinosine 99.31% Unkown
HY-P5275 Tripeptide-41 99.30% Unkown
HY-W348485 WRX606 Inhibitor 95.65% Unkown
HY-130723A AMPK activator 2 hydrochloride Activator 99.68% Unkown
HY-134903 (32-Carbonyl)-RMC-5552 Inhibitor 95.41% Unkown
HY-N11709 Theasaponin E1 99.08% Unkown
HY-P10323A T7 Peptide TFA 98.20% Unkown
HY-114267 Cbz-B3A Inhibitor 98.63% Unkown
HY-176761 NSC647889 99.28% Unkown
HY-N15574 Saringosterol ≥90.0% Unkown
HY-RS04277 EIF4EBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W412264 Pim-1/2 kinase inhibitor 1 Inhibitor 99.78% Unkown
HY-124348 DM-PIT-1 Inhibitor 99.9% Unkown
HY-172609 SL-176 99.91% Unkown
HY-N3027 Soyasaponin Aa Inhibitor 99.88% Unkown
HY-N4253 Kudinoside D 99.80% Unkown
HY-N7661 4β-Hydroxywithanolide E Inhibitor 98% Unkown
HY-P11642A Sialorphin TFA / Unkown
HY-111370 mTOR inhibitor-2 Inhibitor / Unkown
HY-10237S Boceprevir-d9 Inhibitor / Unkown
HY-10466BS Daclatasvir-d6 hydrochloride / Unkown
HY-10466S Daclatasvir-d6 Inhibitor 99.64% Unkown
HY-10466S2 Daclatasvir-d16 Inhibitor / Unkown
HY-115869 RMC-4529 Inhibitor / Unkown
HY-119831 Rohitukine / Unkown
HY-121033 BS148 / Unkown
HY-122670 VS-II-173 / Unkown
HY-126956 Porphyra 334 99.58% Unkown
HY-130723 AMPK activator 2 Activator / Unkown
HY-149292 SR-4133 Inhibitor / Unkown
HY-157482 EBP-59 Inhibitor / Unkown
HY-169751 Dihydro-N-caffeoyltyramine Inhibitor / Unkown
HY-176948 M-1111 Inhibitor / Unkown
HY-181650 T133 / Unkown
HY-181925 FD2024 / Unkown
HY-182957 MNK/PIM-IN-2 / Unkown
HY-B0660S1 Eicosapentaenoic acid 1,2,3,4,5-13C5 Activator / Unkown
HY-B0660S2 Eicosapentaenoic acid-d10 / Unkown
HY-N11507 Tibesaikosaponin V Inhibitor / Unkown
HY-N15121 4-O-Methyl-ascochlorin / Unkown
HY-N3027R Soyasaponin Aa (Standard) Inhibitor / Unkown
HY-N4103R Fucosterol (Standard) Inhibitor / Unkown
HY-P10323 T7 Peptide / Unkown
HY-P11642 Sialorphin / Unkown
HY-P6183 LXJ-02 Inducer / Unkown
HY-RS04130 EBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04278 EIF4EBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04279 EIF4EBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05464 GLB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12834 SH3D19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10466S1 Daclatasvir-13C2,d6 Inhibitor / Unkown
HY-116572 TASIN-1 hydrochloride / Unkown
HY-B0660A Eicosapentaenoic acid metformin Activator / Unkown
HY-N10612 Petasin / Unkown
HY-N1677R 2,6-Dimethoxy-1,4-benzoquinone (Standard) / Unkown
HY-N20754 DHA-free EPA oil / Unkown
HY-RS18892 Ebp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20227 Eif4ebp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20664 Eif4ebp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25383 Ebp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26734 Eif4ebp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27175 Eif4ebp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ebp NCBI NCBI:10682