Bdnf - brain derived neurotrophic factor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12064

Summary

The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Bdnf Products (12)

mRNA Protein Name
NM_001048139.1 NP_001041604.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048141.1 NP_001041606.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048142.1 NP_001041607.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285416.1 NP_001272345.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285417.1 NP_001272346.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285418.1 NP_001272347.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285419.1 NP_001272348.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285420.1 NP_001272349.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285421.1 NP_001272350.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285422.1 NP_001272351.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001316310.1 NP_001303239.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_007540.4 NP_031566.4 brain-derived neurotrophic factor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11684666 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IDA
IDA: Inferred from direct assay
24035762 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15014133 MGI
acts upstream of or within axon target recognition IMP
IMP: Inferred from mutant phenotype
15464571 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
15249684 MGI
acts upstream of or within cellular response to acid chemical IDA
IDA: Inferred from direct assay
25542970 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
23785138 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
12890780 MGI
acts upstream of or within dendrite extension IDA
IDA: Inferred from direct assay
24035762 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
15249684 MGI
acts upstream of or within feeding behavior IMP
IMP: Inferred from mutant phenotype
12796784 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IDA
IDA: Inferred from direct assay
16754670 MGI
acts upstream of or within glutamate secretion IPI
IPI: Inferred from physical interaction
16819522 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24201284 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
7605630 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
15249684 MGI
acts upstream of or within mechanoreceptor differentiation IGI
IGI: Inferred from genetic interaction
15376326 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12904469 MGI
involved in negative regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
26708520 MGI
acts upstream of or within negative regulation of neuroblast proliferation IDA
IDA: Inferred from direct assay
12798291 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
8861722 MGI
acts upstream of or within negative regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
24378336 MGI
acts upstream of or within negative regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
16754670 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
7605630 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
8861722 MGI
acts upstream of or within neuron recognition IMP
IMP: Inferred from mutant phenotype
15844198 MGI
acts upstream of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
23878391 MGI
NOT acts upstream of or within positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
24573299 MGI
acts upstream of or within positive regulation of collateral sprouting IDA
IDA: Inferred from direct assay
24573299 MGI
acts upstream of or within positive regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
24573299 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
12798291 MGI
involved in positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
26708520 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
23878391 MGI
acts upstream of or within regulation of collateral sprouting IGI
IGI: Inferred from genetic interaction
24573299 MGI
acts upstream of or within regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16516892 MGI
acts upstream of or within regulation of retinal cell programmed cell death IDA
IDA: Inferred from direct assay
11747369 MGI
acts upstream of or within regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
16819522 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
15249684 MGI
acts upstream of or within taste bud development IMP
IMP: Inferred from mutant phenotype
24378336 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission EXP
EXP: Inferred from Experiment
19448629 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
IDA: Inferred from direct assay
19448629 MGI
acts upstream of or within ureteric bud development IDA
IDA: Inferred from direct assay
16018995 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19448629 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22209827 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14715936 MGI
located in dendrite IDA
IDA: Inferred from direct assay
19448629 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
19448629 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19448629 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
22412021 MGI
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
22412021 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
22209827 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
24573299 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brain-derived neurotrophic factor

Recombinant Bdnf Proteins

Cat. No. Product Name Accession Purity
HY-P74383 BDNF Protein, Mouse (R129A, R130A, HEK293, His, Solution) P21237-1 (A19-R249, R129A, R130A) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0531 Triflusal 99.56% Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-B1618 Corticosterone Agonist 99.77% Phase 3
HY-16728 Rapastinel 99.78% Phase 3
HY-139897 CX 717 Agonist 99.95% Phase 2
HY-110255 AZD 2066 99.8% Phase 2
HY-110255A AZD 2066 hydrate ≥99.0% Phase 2
HY-120251A Leteprinim potassium Inhibitor 99.0% Phase 2
HY-184424 HDAC6-IN-84 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (85)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W013372 7,8-Dihydroxyflavone 99.74% Unkown
HY-106224B Orexin A (human, rat, mouse) acetate Agonist 99.53% Unkown
HY-P1178 Cyclotraxin B Inhibitor 99.78% Unkown
HY-18939 N6-Cyclohexyladenosine 99.98% Unkown
HY-114384B Mefluleucine hydrochloride Activator 98.0% Unkown
HY-120657 9-PAHSA 99.88% Unkown
HY-100115 TA-02 Inhibitor 99.44% Unkown
HY-N2125 Parishin C Agonist 99.24% Unkown
HY-N2038 3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone Inhibitor 99.86% Unkown
HY-N2055 Kaempferol 3-O-sophoroside 99.41% Unkown
HY-P1146 Semax Inhibitor 99.56% Unkown
HY-N0392 Polygalasaponin F 99.85% Unkown
HY-110166 PD 90780 98.83% Unkown
HY-N7981 Pratensein Inhibitor 99.92% Unkown
HY-13999 Amdiglurax 99.53% Yes
HY-122742 HBT1 99.73% Unkown
HY-W747599 Ganglioside GQ1b (bovine) sodium ≥98.0% Unkown
HY-124591 TC-2153 Inhibitor 98.19% Unkown
HY-14569 CDPPB 98.01% Unkown
HY-W044525 Phyllodulcin Inhibitor 99.75% Unkown
HY-153383 PDCD4-IN-1 Inhibitor 99.41% Unkown
HY-16728B Rapastinel Trifluoroacetate 98.0% Unkown
HY-W749694 Cannflavin B Inhibitor 98.36% Unkown
HY-N2736 3′,4′,7-Trihydroxyflavone Inhibitor 99.04% Unkown
HY-P1146A Semax acetate Inhibitor 99.39% Unkown
HY-121793 Roemerine Inhibitor 99.89% Unkown
HY-111527 PPZ2 99.92% Unkown
HY-173025 Nurr1 agonist 12 Agonist 99.62% Unkown
HY-N6076 Tenuifoliside A Inhibitor 98.09% Unkown
HY-142026 Vitisin A 96% Unkown
HY-N1414A 3′,6-Disinapoylsucrose Inhibitor 98.88% Unkown
HY-132993 Hcyb1 Inhibitor 98.20% Unkown
HY-N1414 (E)-3',6-Disinapoylsucrose 99.59% Unkown
HY-N3097 Pellitorine 99.84% Unkown
HY-RS01460 BDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N8693 Withanoside IV 98.47% Unkown
HY-RS16220 Bdnf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102091 (2R,4R)-APDC Agonist / Unkown
HY-102091A (2R,4R)-APDC hydrate Agonist 98.0% Unkown
HY-13999A1 Amdiglurax phosphate Activator 99.75% Unkown
HY-160921 Capeserod Agonist 98.66% Unkown
HY-172876 FLY26 99.66% Unkown
HY-179390 KMCA-0011 Antagonist 99.88% Unkown
HY-N2125R Parishin C (Standard) Agonist 98.88% Unkown
HY-W770410 9-PAHSA-13C4 99.9% Unkown
HY-144026S 9-PAHSA-d9 / Unkown
HY-169964 TSPO/Carbonic Anhydrase Modulator 1 Modulator / Unkown
HY-120251 Leteprinim Inhibitor / Unkown
HY-120306 HHL-6 Inhibitor / Unkown
HY-121012 (rac)-AG-205 / Unkown
HY-123222 CGP 56999 Antagonist / Unkown
HY-123439 FTY720-C2 Inhibitor 99.64% Unkown
HY-138967 BRF110 / Unkown
HY-139806 SRA880 free base Inhibitor / Unkown
HY-146523 TRK-IN-17 Inhibitor / Unkown
HY-146524 TRK-IN-18 Inhibitor / Unkown
HY-157792 Antidepressant agent 6 Antagonist / Unkown
HY-16728A Rapastinel acetate / Unkown
HY-174337 PX5–9 / Unkown
HY-174339 Neuroprotective agent 12 / Unkown
HY-174419 TFSeB / Unkown
HY-175483S TrkB activator-1 Activator / Unkown
HY-178153 BPAM363 Modulator / Unkown
HY-179337 PDE2-IN-1 / Unkown
HY-181998 CN016 Inhibitor / Unkown
HY-184011 SERT-IN-4 / Unkown
HY-D2970 Golgi-P / Unkown
HY-E70870 TRKB(NTRK2) Recombinant Human Active Protein Kinase / Unkown
HY-N0392R Polygalasaponin F (Standard) Inhibitor / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-N20637 Polygalasaponin XXXII Activator / Unkown
HY-N4161 Euparin Inhibitor 99.0% Unkown
HY-P11092 TLQP-62 (mouse,rat) / Unkown
HY-P1178A Cyclotraxin B TFA Inhibitor / Unkown
HY-110255B AZD-2066 hydrochloride / Unkown
HY-120657S 9-PAHSA-d4 / Unkown
HY-120657S1 9-PAHSA-d31 99.00% Unkown
HY-124503 Longanlactone Activator / Unkown
HY-164461 AZD6918 Inhibitor / Unkown
HY-167836 BNN-20 Activator / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-N11872 Suffruticosol A Activator / Unkown
HY-N7773 Hibiscetin / Unkown
HY-RS22932 Bdnf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991413 ZEB85 Activator 96.3985% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bdnf NCBI NCBI:627