Ltb - lymphotoxin B Gene

Also Known as p33; Tnfc; LTbeta; Tnfsf3; Tnlg1c

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16994

Summary

Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in positive regulation of interleukin-12 production. Acts upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human LTB (lymphotoxin beta). [provided by Alliance of Genome Resources, Apr 2022]

Ltb Products (1)

mRNA Protein Name
NM_008518.2 NP_032544.1 lymphotoxin-beta

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
17673451 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
9133428 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
17982081 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17673451 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphotoxin-beta

  • LT-beta

  • TNF-C

  • tumor necrosis factor C

  • tumor necrosis factor ligand 1c

  • tumor necrosis factor ligand superfamily member 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-I0021 Bepotastine Antagonist 99.88% Unkown
HY-A0015 Bepotastine besilate Antagonist 99.77% Unkown
HY-I0021A Bepotastine tosylate Antagonist / Unkown
HY-I0021R Bepotastine (Standard) Antagonist / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-101438 Darbufelone Inhibitor 99.49% Phase 3
HY-107608 Leukotriene B4 ≥98.0% Phase 2
HY-15874 Fiboflapon Inhibitor 99.50% Phase 2
HY-13628 Etalocib 99.03% Phase 2
HY-112737 LY223982 Inhibitor 99.65% Phase 2
HY-19304 Amelubant Antagonist 98.45% Phase 2
HY-15874A Fiboflapon sodium Inhibitor 98.51% Phase 2
HY-19166 E-6700 Inhibitor / Phase 2
HY-19198 SB-201993 Antagonist / Phase 2
HY-105176 Ontazolast Inhibitor / Phase 2
HY-19221 Bay-y-1015 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (99)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-101408 Docosatrienoic Acid 99.9% Unkown
HY-15744 LY255283 Antagonist 98.04% Unkown
HY-114641A BIIL-260 hydrochloride Antagonist 99.90% Unkown
HY-W073687 2,4,6-Triiodophenol Inducer 99.52% Unkown
HY-107608S Leukotriene B4-d4 99.14% Unkown
HY-108396 γ-Linolenic acid ethyl ester Antagonist 99.14% Unkown
HY-N1942 5-O-Demethylnobiletin Inhibitor 99.91% Unkown
HY-106929 Moxilubant Antagonist 99.83% Unkown
HY-113483 20-Carboxy-Leukotriene B4 Inhibitor 98.53% Unkown
HY-149589 11(Z),14(Z)-Eicosadienoic acid Inhibitor ≥98.0% Unkown
HY-112621 Leukotriene A4 methyl ester 99.9% Unkown
HY-14165A (S)-Veliflapon Inhibitor 99.25% Unkown
HY-A0015A (Rac)-Bepotastine besilate Inhibitor 99.52% Unkown
HY-101438A Darbufelone mesylate Inhibitor 99.65% Unkown
HY-10437 Setileuton Inhibitor 99.9% Unkown
HY-112741 SB-209247 Antagonist 99.33% Unkown
HY-112742 CP-195543 Antagonist 98.86% Unkown
HY-115369 Methyl (13Z,16Z,19Z)-docosatrienoate 99.9% Unkown
HY-156736 HSD17B13-IN-3 Inhibitor 99.78% Unkown
HY-161212 HSD17B13-IN-8 Inhibitor 99.97% Unkown
HY-N4267 Yangambin 98.27% Unkown
HY-W341962 Halometasone Inhibitor 98.47% Unkown
HY-12995A (S)-BI 665915 Inhibitor / Unkown
HY-100173 DW-1350 Antagonist / Unkown
HY-101579 LY 178002 99.60% Unkown
HY-10437A Setileuton tosylate Inhibitor / Unkown
HY-105504 CI-986 Inhibitor / Unkown
HY-105711 RBx-7796 sodium Inhibitor / Unkown
HY-105933 L-652343 Inhibitor / Unkown
HY-106929B Moxilubant hydrochloride Antagonist / Unkown
HY-107608A 5(S),12(S)-Leukotriene B4 / Unkown
HY-112740 SC-53228 Antagonist / Unkown
HY-113479 20-Hydroxy-leukotriene B4 / Unkown
HY-113484 Leukotriene B5 Activator / Unkown
HY-113879 18-Carboxy dinor Leukotriene B4 / Unkown
HY-114641 BIIL-260 Antagonist / Unkown
HY-115390 14,15-Dehydro Leukotriene B4 Antagonist / Unkown
HY-115500 PL265 / Unkown
HY-117896 SC-50605 Antagonist / Unkown
HY-119094 WAY-196025 Inhibitor / Unkown
HY-120539 Enofelast Inhibitor / Unkown
HY-121621 RO5101576 / Unkown
HY-123008 Reproterol hydrochloride / Unkown
HY-123014 (Rac)-SC-45694 Agonist / Unkown
HY-123014A SC-45694 lithium / Unkown
HY-123575 LY 245769 Inhibitor / Unkown
HY-124100 LTB4 antagonist 4 / Unkown
HY-12995 BI 665915 Inhibitor / Unkown
HY-12996 AZD6642 Inhibitor / Unkown
HY-130497 12-Oxo-leukotriene B4 / Unkown
HY-131651 Leukotriene B4 ethanolamide Antagonist / Unkown
HY-134123 Lipoxin B4 methyl ester / Unkown
HY-13628A Etalocib sodium / Unkown
HY-137350 12-epi-LTB4 Agonist / Unkown
HY-138050 Nyasol Inhibitor / Unkown
HY-139112 Leukotriene B4 dimethyl amide / Unkown
HY-149082 LTB4 antagonist 1 Antagonist / Unkown
HY-149083 LTB4 antagonist 2 Antagonist / Unkown
HY-149084 LTB4 antagonist 3 Antagonist / Unkown
HY-155204 LTB4-IN-2 Inhibitor / Unkown
HY-155300 BLT2 antagonist-1 Antagonist / Unkown
HY-168015 5-Oxo leukotriene B4 / Unkown
HY-169434 LTB Inhibitor / Unkown
HY-169435 TK-OH 98.36% Unkown
HY-169436 Lon-TK Inhibitor / Unkown
HY-180411 SM-15178 Antagonist / Unkown
HY-182422 CGS 23885 Inhibitor / Unkown
HY-182696 CGS 24891 Inhibitor / Unkown
HY-185709 2-ARA-LysoPtdEtn / Unkown
HY-19114 WY-50295 Inhibitor / Unkown
HY-CE00537 18-CoA-18-oxo-dinor-LTB4 / Unkown
HY-N7801 (±)5-HEPE / Unkown
HY-RS07872 LTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07873 LTB4R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07874 Ltb4r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07875 Ltb4r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07876 LTB4R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W744842 γ-Linolenic acid ethyl ester-d5 / Unkown
HY-W747565 Leukotriene B4-3-aminopropylamide / Unkown
HY-106929R Moxilubant (Standard) Antagonist / Unkown
HY-107608S1 Leukotriene B4-d5 / Unkown
HY-113628 ABT-080 Inhibitor 98.42% Unkown
HY-117557 LY306669 Antagonist / Unkown
HY-117706 LY 292728 Antagonist / Unkown
HY-117854 SB 201146 Antagonist / Unkown
HY-118156 L-699333 / Unkown
HY-118848 A63162 Inhibitor / Unkown
HY-120606 A-78773 Inhibitor / Unkown
HY-122536 Ricinelaidic acid / Unkown
HY-14162 AM103 free acid Inhibitor / Unkown
HY-141635 cis-11,14-Eicosadienoic acid methyl ester 98.05% Unkown
HY-174587 Human LTB mRNA / Unkown
HY-N11072 Tremulacin Inhibitor 96.41% Unkown
HY-RS16892 Ltb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23334 Ltb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00170 Bunaprolast Inhibitor / Unkown
HY-U00263 LY210073 Antagonist / Unkown
HY-U00299 LTB4-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ltb NCBI NCBI:4050