LTB - lymphotoxin beta Gene

Also Known as p33; TNFC; TNFSF3; TNLG1C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4050

About LTB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,580,558-31,582,425 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 86 orthologues and 8 paralogues. Biased expression in spleen (RPKM 84.6), lymph node (RPKM 56.9) and 8 other tissues.

Summary

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LTB Products (2)

mRNA Protein Name
NM_002341.2 NP_002332.1 lymphotoxin-beta isoform a
NM_009588.1 NP_033666.1 lymphotoxin-beta isoform b

LTB Protein Structure

TNF

TNF: TNF(Tumour Necrosis Factor) family (102 - 243)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

lymphotoxin-beta

  • LT-beta

Related Diseases

Diseases Alias
Synovitis
Osteogenesis Imperfecta, Type Xxi

  • OI21

  • Osteogenesis Imperfecta Type 21

  • Osteogenesis Imperfecta, Type 21

  • Osteogenesis Imperfecta Type Xxi

  • Osteogenesis Imperfecta 21
Type 1 Diabetes Mellitus 2

  • Diabetes Mellitus, Noninsulin-Dependent, 1

  • Diabetes Mellitus, Insulin-Dependent, 2

  • IDDM2

  • Insulin-Dependent Diabetes Mellitus 2

  • NIDDM1

  • Diabetes Mellitus, Noninsulin-Dependent 1

  • T1D2

  • Type 2 Diabetes Mellitus 1

  • T2D1

  • Noninsulin-Dependent Diabetes Mellitus 1

  • Diabetes Mellitus, Non-Insulin-Dependent, 1

  • Type 2 Diabetes Mellitus 1, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 2

  • Diabetes Mellitus, Non-Insulin-Dependent
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-I0021 Bepotastine Antagonist 99.88% Unkown
HY-A0015 Bepotastine besilate Antagonist 99.77% Unkown
HY-I0021A Bepotastine tosylate Antagonist / Unkown
HY-I0021R Bepotastine (Standard) Antagonist / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-101438 Darbufelone Inhibitor 99.49% Phase 3
HY-107608 Leukotriene B4 ≥98.0% Phase 2
HY-15874 Fiboflapon Inhibitor 99.50% Phase 2
HY-13628 Etalocib 99.03% Phase 2
HY-112737 LY223982 Inhibitor 99.65% Phase 2
HY-19304 Amelubant Antagonist 98.45% Phase 2
HY-15874A Fiboflapon sodium Inhibitor 98.51% Phase 2
HY-19166 E-6700 Inhibitor / Phase 2
HY-19198 SB-201993 Antagonist / Phase 2
HY-105176 Ontazolast Inhibitor / Phase 2
HY-19221 Bay-y-1015 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (99)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-101408 Docosatrienoic Acid 99.9% Unkown
HY-15744 LY255283 Antagonist 98.04% Unkown
HY-114641A BIIL-260 hydrochloride Antagonist 99.90% Unkown
HY-W073687 2,4,6-Triiodophenol Inducer 99.52% Unkown
HY-107608S Leukotriene B4-d4 99.14% Unkown
HY-108396 γ-Linolenic acid ethyl ester Antagonist 99.14% Unkown
HY-N1942 5-O-Demethylnobiletin Inhibitor 99.91% Unkown
HY-106929 Moxilubant Antagonist 99.83% Unkown
HY-113483 20-Carboxy-Leukotriene B4 Inhibitor 98.53% Unkown
HY-149589 11(Z),14(Z)-Eicosadienoic acid Inhibitor 98.0% Unkown
HY-112621 Leukotriene A4 methyl ester 99.9% Unkown
HY-14165A (S)-Veliflapon Inhibitor 99.25% Unkown
HY-A0015A (Rac)-Bepotastine besilate Inhibitor 99.52% Unkown
HY-101438A Darbufelone mesylate Inhibitor 99.65% Unkown
HY-10437 Setileuton Inhibitor 99.9% Unkown
HY-112741 SB-209247 Antagonist 99.33% Unkown
HY-112742 CP-195543 Antagonist 98.86% Unkown
HY-115369 Methyl (13Z,16Z,19Z)-docosatrienoate 99.9% Unkown
HY-156736 HSD17B13-IN-3 Inhibitor 99.78% Unkown
HY-161212 HSD17B13-IN-8 Inhibitor 99.97% Unkown
HY-N4267 Yangambin 98.27% Unkown
HY-W341962 Halometasone Inhibitor 98.47% Unkown
HY-12995A (S)-BI 665915 Inhibitor / Unkown
HY-100173 DW-1350 Antagonist / Unkown
HY-101579 LY 178002 99.60% Unkown
HY-10437A Setileuton tosylate Inhibitor / Unkown
HY-105504 CI-986 Inhibitor / Unkown
HY-105711 RBx-7796 sodium Inhibitor / Unkown
HY-105933 L-652343 Inhibitor / Unkown
HY-106929B Moxilubant hydrochloride Antagonist / Unkown
HY-107608A 5(S),12(S)-Leukotriene B4 / Unkown
HY-112740 SC-53228 Antagonist / Unkown
HY-113479 20-Hydroxy-leukotriene B4 / Unkown
HY-113484 Leukotriene B5 Activator / Unkown
HY-113879 18-Carboxy dinor Leukotriene B4 / Unkown
HY-114641 BIIL-260 Antagonist / Unkown
HY-115390 14,15-Dehydro Leukotriene B4 Antagonist / Unkown
HY-115500 PL265 / Unkown
HY-117896 SC-50605 Antagonist / Unkown
HY-119094 WAY-196025 Inhibitor / Unkown
HY-120539 Enofelast Inhibitor / Unkown
HY-121621 RO5101576 / Unkown
HY-123008 Reproterol hydrochloride / Unkown
HY-123014 (Rac)-SC-45694 Agonist / Unkown
HY-123014A SC-45694 lithium / Unkown
HY-123575 LY 245769 Inhibitor / Unkown
HY-124100 LTB4 antagonist 4 / Unkown
HY-12995 BI 665915 Inhibitor / Unkown
HY-12996 AZD6642 Inhibitor / Unkown
HY-130497 12-Oxo-leukotriene B4 / Unkown
HY-131651 Leukotriene B4 ethanolamide Antagonist / Unkown
HY-134123 Lipoxin B4 methyl ester / Unkown
HY-13628A Etalocib sodium / Unkown
HY-137350 12-epi-LTB4 Agonist / Unkown
HY-138050 Nyasol Inhibitor / Unkown
HY-139112 Leukotriene B4 dimethyl amide / Unkown
HY-149082 LTB4 antagonist 1 Antagonist / Unkown
HY-149083 LTB4 antagonist 2 Antagonist / Unkown
HY-149084 LTB4 antagonist 3 Antagonist / Unkown
HY-155204 LTB4-IN-2 Inhibitor / Unkown
HY-155300 BLT2 antagonist-1 Antagonist / Unkown
HY-168015 5-Oxo leukotriene B4 / Unkown
HY-169434 LTB Inhibitor / Unkown
HY-169435 TK-OH 98.36% Unkown
HY-169436 Lon-TK Inhibitor / Unkown
HY-180411 SM-15178 Antagonist / Unkown
HY-182422 CGS 23885 Inhibitor / Unkown
HY-182696 CGS 24891 Inhibitor / Unkown
HY-185709 2-ARA-LysoPtdEtn / Unkown
HY-19114 WY-50295 Inhibitor / Unkown
HY-CE00537 18-CoA-18-oxo-dinor-LTB4 / Unkown
HY-N7801 (±)5-HEPE / Unkown
HY-RS07872 LTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07873 LTB4R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07874 Ltb4r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07875 Ltb4r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07876 LTB4R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W744842 γ-Linolenic acid ethyl ester-d5 / Unkown
HY-W747565 Leukotriene B4-3-aminopropylamide / Unkown
HY-106929R Moxilubant (Standard) Antagonist / Unkown
HY-107608S1 Leukotriene B4-d5 / Unkown
HY-113628 ABT-080 Inhibitor 98.42% Unkown
HY-117557 LY306669 Antagonist / Unkown
HY-117706 LY 292728 Antagonist / Unkown
HY-117854 SB 201146 Antagonist / Unkown
HY-118156 L-699333 / Unkown
HY-118848 A63162 Inhibitor / Unkown
HY-120606 A-78773 Inhibitor / Unkown
HY-122536 Ricinelaidic acid / Unkown
HY-14162 AM103 free acid Inhibitor / Unkown
HY-141635 cis-11,14-Eicosadienoic acid methyl ester 98.05% Unkown
HY-174587 Human LTB mRNA / Unkown
HY-N11072 Tremulacin Inhibitor 96.41% Unkown
HY-RS16892 Ltb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23334 Ltb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00170 Bunaprolast Inhibitor / Unkown
HY-U00263 LY210073 Antagonist / Unkown
HY-U00299 LTB4-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LTB VGNC VGNC:68101
Macaca mulatta LTB VGNC VGNC:74454
Bos taurus LTB VGNC VGNC:31068
Rattus norvegicus LTB RGD RGD:1303162
Mus musculus LTB MGD MGI:104796
Canis familiaris LTB VGNC VGNC:42854
Others LTB NCBI