LTB - lymphotoxin beta Gene

Homo sapiens

Also known as p33; TNFC; TNFSF3; TNLG1C

Gene ID: 4050 | Gene type: protein coding

About LTB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,580,558-31,582,425 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 86 orthologues and 8 paralogues. Biased expression in spleen (RPKM 84.6), lymph node (RPKM 56.9) and 8 other tissues.

Summary

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LTB Products(2)

mRNA	Protein	Name
NM_002341.2	NP_002332.1	lymphotoxin-beta isoform a
NM_009588.1	NP_033666.1	lymphotoxin-beta isoform b

LTB Protein Structure

TNF

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

lymphotoxin-beta

LT-beta

Related Diseases

Diseases

Alias

Synovitis

Osteogenesis Imperfecta, Type Xxi

OI21	Osteogenesis Imperfecta Type 21
Osteogenesis Imperfecta, Type 21	Osteogenesis Imperfecta Type Xxi
Osteogenesis Imperfecta 21

Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1	Diabetes Mellitus, Insulin-Dependent, 2
IDDM2	Insulin-Dependent Diabetes Mellitus 2
NIDDM1	Diabetes Mellitus, Noninsulin-Dependent 1
T1D2	Type 2 Diabetes Mellitus 1
T2D1	Noninsulin-Dependent Diabetes Mellitus 1
Diabetes Mellitus, Non-Insulin-Dependent, 1	Type 2 Diabetes Mellitus 1, Susceptibility To
Diabetes Mellitus, Insulin-Dependent, Type 2	Diabetes Mellitus, Non-Insulin-Dependent

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-I0021	Bepotastine	Antagonist	98.03%	Unkown
HY-B0174A	Olsalazine	Inhibitor	99.64%	Unkown
HY-A0015	Bepotastine besilate	Antagonist	99.77%	Unkown
HY-I0021A	Bepotastine tosylate	Antagonist	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107608	Leukotriene B4		≥98.0%	Phase 2
HY-15874	Fiboflapon	Inhibitor	98.54%	Phase 2
HY-13628	Etalocib		98.74%	Phase 2
HY-15874A	Fiboflapon sodium	Inhibitor	99.91%	Phase 2
HY-19304	Amelubant		99.11%	Phase 2

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-N7176	Kaempferol 3-O-β-D-glucuronide	Modulator	99.41%	Unkown
HY-15744	LY255283	Antagonist	98.52%	Unkown
HY-114641A	BIIL-260 hydrochloride	Antagonist	99.90%	Unkown
HY-101408	Docosatrienoic Acid		≥99.0%	Unkown
HY-N1942	5-O-Demethylnobiletin		99.93%	Unkown
HY-101438A	Darbufelone mesylate	Inhibitor	98.45%	Unkown
HY-112737	LY223982	Inhibitor	99.67%	Unkown
HY-W073687	2,4,6-Triiodophenol	Inducer	98.29%	Unkown
HY-108396	γ-Linolenic acid ethyl ester	Antagonist	99.14%	Unkown
HY-161212	HSD17B13-IN-8	Inhibitor	99.97%	Unkown
HY-113483	20-Carboxy-Leukotriene B4	Inhibitor	≥98.0%	Unkown
HY-101438	Darbufelone		≥98.0%	Unkown
HY-12995A	(S)-BI 665915	Inhibitor	/	Unkown
HY-100173	DW-1350	Antagonist	/	Unkown
HY-10437	Setileuton	Inhibitor	/	Unkown
HY-107608S	Leukotriene B4-d4		/	Unkown
HY-112742	CP-195543	Antagonist	/	Unkown
HY-113479	20-Hydroxy-leukotriene B4		/	Unkown
HY-115369	Methyl (13Z,16Z,19Z)-docosatrienoate		/	Unkown
HY-120539	Enofelast	Inhibitor	/	Unkown
HY-130497	12-Oxo-leukotriene B4		/	Unkown
HY-131651	Leukotriene B4 ethanolamide	Antagonist	/	Unkown
HY-137350	12-epi-LTB4	Agonist	/	Unkown
HY-138050	Nyasol	Inhibitor	/	Unkown
HY-139112	Leukotriene B4 dimethyl amide		/	Unkown
HY-14165A	(S)-Veliflapon	Inhibitor	99.44%	Unkown
HY-149082	LTB4 antagonist 1	Antagonist	/	Unkown
HY-149083	LTB4 antagonist 2	Antagonist	/	Unkown
HY-149084	LTB4 antagonist 3	Antagonist	/	Unkown
HY-155204	LTB4-IN-2	Inhibitor	/	Unkown
HY-155300	BLT2 antagonist-1	Antagonist	/	Unkown
HY-19443	UCB-35440		/	Unkown
HY-A0015A	(Rac)-Bepotastine besilate		99.52%	Unkown
HY-RS07872	LTB Human Pre-designed siRNA Set A		/	Unkown
HY-RS07873	LTB4R Human Pre-designed siRNA Set A		/	Unkown
HY-RS07874	Ltb4r Rat Pre-designed siRNA Set A		/	Unkown
HY-RS07875	Ltb4r1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS07876	LTB4R2 Human Pre-designed siRNA Set A		/	Unkown
HY-W747565	Leukotriene B4-3-aminopropylamide		/	Unkown
HY-101579	LY 178002		/	Unkown
HY-113628	ABT-080	Inhibitor	/	Unkown
HY-117557	LY306669	Antagonist	/	Unkown
HY-117706	LY 292728	Antagonist	/	Unkown
HY-149589	11(Z),14(Z)-Eicosadienoic acid	Inhibitor	/	Unkown
HY-B0174AS1	Olsalazine-d3	Inhibitor	/	Unkown
HY-B0174AS2	Olsalazine-d3,15N	Inhibitor	/	Unkown
HY-U00170	Bunaprolast	Inhibitor	/	Unkown
HY-U00263	LY210073	Antagonist	/	Unkown
HY-U00299	LTB4-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LTB	VGNC	VGNC:68101
Macaca mulatta	LTB	VGNC	VGNC:74454
Bos taurus	LTB	VGNC	VGNC:31068
Rattus norvegicus	LTB	RGD	RGD:1303162
Mus musculus	LTB	MGD	MGI:104796
Canis familiaris	LTB	VGNC	VGNC:42854
Macaca fascicularis	LTB	NCBI
Others	LTB	NCBI

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