2. Gene
  3. Syk - spleen tyrosine kinase Gene

Syk - spleen tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sykb

Gene ID: 20963 | Gene type: protein coding

About Syk

Chromosome 13: 52,737,209-52,802,828 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 202 orthologues, 32 paralogues and is associated with 77 phenotypes. Biased expression in spleen adult (RPKM 36.), mammary gland adult (RPKM 7.6) and 11 other tissues.

Summary

Enables several functions, including ATP binding activity; SH2 domain binding activity; and Enzyme binding activity. Involved in several processes, including cell surface receptor signaling pathway; myeloid cell activation involved in immune response; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including positive regulation of leukocyte activation; positive regulation of macromolecule metabolic process; and protein phosphorylation. Located in early phagosome. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human Syk (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Syk Products(2)

mRNA Protein Name
NM_001198977.1 NP_001185906.1 tyrosine-protein kinase SYK
NM_011518.2 NP_035648.2 tyrosine-protein kinase SYK

Syk Protein Structure

SH2_N-SH2_Zap70_Syk_like

SH2_N-SH2_Zap70_Syk_like: cd09938 (11 - 114)

SH2_C-SH2_Syk_like

SH2_C-SH2_Syk_like: cd10401 (162 - 260)

PTKc_Syk

PTKc_Syk: cd05116 (369 - 624)

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  • 629 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase SYK

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13038A Fostamatinib Inhibitor 99.50% Yes
HY-13038 Fostamatinib Disodium Inhibitor 99.88% Yes
HY-13038B Fostamatinib disodium hexahydrate Inhibitor 99.73% Yes
Clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-15968 Entospletinib Inhibitor 99.88% Phase 3
HY-15999 Cerdulatinib Inhibitor 98.96% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 99.89% Phase 3
HY-15323 PRT062607 Hydrochloride Inhibitor 98.68% Phase 2
HY-109091 Lanraplenib Inhibitor 99.12% Phase 2
HY-103018 Gusacitinib Inhibitor 99.41% Phase 2
HY-100867A TAK-659 hydrochloride Inhibitor 99.91% Phase 2
HY-109082 Cevidoplenib Inhibitor 98.08% Phase 2
HY-109091B Lanraplenib succinate Inhibitor 98.58% Phase 2
HY-100867 TAK-659 Inhibitor / Phase 2
HY-109091A Lanraplenib monosuccinate Inhibitor / Phase 2
HY-15322 PRT062607 Inhibitor / Phase 2
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12067 R406 Inhibitor 98.72% Unkown
HY-13518 Piceatannol Inhibitor 98.90% Unkown
HY-11108 R406 free base Inhibitor 99.80% Unkown
HY-14985 BAY 61-3606 dihydrochloride Inhibitor 99.91% Unkown
HY-112390A Syk Inhibitor II Inhibitor 98.05% Unkown
HY-12974 PRT-060318 Inhibitor 99.36% Unkown
HY-78263 MNS Inhibitor 99.55% Unkown
HY-16902 RO9021 Inhibitor 98.76% Unkown
HY-145598 Sovleplenib Inhibitor 99.56% Unkown
HY-16420 R112 Inhibitor 99.71% Unkown
HY-136198 SRX3207 Inhibitor 98.50% Unkown
HY-12657 Syk-IN-1 Inhibitor 99.18% Unkown
HY-12736A GSK143 dihydrochloride Inhibitor 99.73% Unkown
HY-131341 Syk-IN-4 Inhibitor 98.05% Unkown
HY-109082A Cevidoplenib dimesylate Inhibitor 98.48% Unkown
HY-151634 Syk-IN-6 Inhibitor / Unkown
HY-108489 ER-27319 maleate Inhibitor ≥99.4% Unkown
HY-10230S Midostaurin-d5 Inhibitor ≥98.0% Unkown
HY-138961 ER-27319 Inhibitor / Unkown
HY-112386 OXSI-2 Inhibitor / Unkown
HY-76474 BAY 61-3606 Inhibitor 98.21% Unkown
HY-130680 Syk-IN-3 Inhibitor / Unkown
HY-103018A Gusacitinib hydrochloride Inhibitor / Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-P2504 Syk Kinase Peptide Substrate, Biotin labeled / Unkown
HY-N3702 Dehydroabietinol Inhibitor / Unkown
HY-12736 GSK143 Inhibitor / Unkown
HY-P2505 Syk Kinase Peptide Substrate / Unkown
HY-112390 Syk Inhibitor II dihydrochloride Inhibitor / Unkown
HY-120214 TAS05567 Inhibitor / Unkown
HY-155513 Syk-IN-8 Inhibitor / Unkown
HY-112390B Syk Inhibitor II dihydrochloride dihydrate Inhibitor / Unkown
HY-145029 SYK/JAK-IN-1 Inhibitor / Unkown
HY-149895 Syk-IN-7 Inhibitor / Unkown
HY-162427 NMS-0963 Inhibitor / Unkown
HY-N7314 Asebogenin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syk NCBI NCBI:6850