2. Gene
  3. Bace1 - beta-site APP cleaving enzyme 1 Gene

Bace1 - beta-site APP cleaving enzyme 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ASP2; Bace

Gene ID: 23821 | Gene type: protein coding

About Bace1

Chromosome 9: 45,749,878-45,775,697 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 36 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 19.1), ovary adult (RPKM 19.) and 28 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta Peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

Bace1 Products(5)

mRNA Protein Name
NM_001410456.1 NP_001397385.1 beta-secretase 1 isoform 4
NM_001410455.1 NP_001397384.1 beta-secretase 1 isoform 3 precursor
NM_001410457.1 NP_001397386.1 beta-secretase 1 isoform 5
NM_001145947.3 NP_001139419.1 beta-secretase 1 isoform 2 precursor
NM_011792.7 NP_035922.4 beta-secretase 1 isoform 1 preproprotein

Bace1 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

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  • 501 a.a.
Protein Preferred Names Protein Names

beta-secretase 1

APP beta-secretase

asp 2

aspartyl protease 2

beta-site amyloid precursor protein cleaving enzyme 1

memapsin-2

membrane-associated aspartic protease 2

Recombinant Bace1 Proteins

Cat. No. Product Name Accession Purity
HY-P72843 BACE1 Protein, Mouse (HEK293, His) NP_035922.4 (T22-T457) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.82% Phase 3
HY-114245 Se-Methylselenocysteine Inhibitor ≥98.0% Phase 1
HY-10472 LY2811376 Inhibitor 99.89% Phase 1
HY-109052 Atabecestat Inhibitor 99.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-136742 BACE2-IN-1 Inhibitor 99.34% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-111383 LX2343 Inhibitor 99.80% Unkown
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-112444 BACE1-IN-2 Inhibitor / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128774 AM-6494 Inhibitor / Unkown
HY-128594 BACE1-IN-4 Inhibitor / Unkown
HY-151348 BACE1-IN-11 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-P3426 BACE1-IN-10 Inhibitor / Unkown
HY-139720 β-Secretase Inhibitor III Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace1 NCBI NCBI:23621