Bace1 - beta-site APP cleaving enzyme 1 Gene

Also Known as ASP2; Bace

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23821

About Bace1

Chromosome 9: 45,749,878-45,775,697 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 36 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 19.1), ovary adult (RPKM 19.) and 28 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

Bace1 Products (5)

mRNA Protein Name
NM_001410456.1 NP_001397385.1 beta-secretase 1 isoform 4
NM_001410455.1 NP_001397384.1 beta-secretase 1 isoform 3 precursor
NM_001410457.1 NP_001397386.1 beta-secretase 1 isoform 5
NM_001145947.3 NP_001139419.1 beta-secretase 1 isoform 2 precursor
NM_011792.7 NP_035922.4 beta-secretase 1 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IDA
IDA: Inferred from direct assay
25592972 MGI
enables aspartic-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
29325091 MGI
enables endopeptidase activity IDA
IDA: Inferred from direct assay
15123597 MGI
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
17099708 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15606899 MGI
Biological Process GO Annotation Evidence References Source
involved in amyloid precursor protein catabolic process IGI
IGI: Inferred from genetic interaction
20704561 MGI
acts upstream of or within amyloid-beta metabolic process IDA
IDA: Inferred from direct assay
25592972 MGI
involved in membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
29325091 MGI
involved in modulation of chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
20943921 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
18753368 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
18753368 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
15123597 MGI
involved in signaling receptor ligand precursor processing IMP
IMP: Inferred from mutant phenotype
17099708 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11740561 MGI
located in cell surface IDA
IDA: Inferred from direct assay
26467158 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11740561 MGI
located in early endosome IDA
IDA: Inferred from direct assay
25592972 MGI
located in endosome IDA
IDA: Inferred from direct assay
19074428 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
18753368 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
18753368 MGI
located in membrane IDA
IDA: Inferred from direct assay
15886206 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29325091 MGI
is active in plasma membrane IMP
IMP: Inferred from mutant phenotype
17099708 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
23820808 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
23931995 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19074428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace1 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

beta-secretase 1

  • APP beta-secretase

  • asp 2

  • aspartyl protease 2

  • beta-site amyloid precursor protein cleaving enzyme 1

  • memapsin-2

  • membrane-associated aspartic protease 2

Recombinant Bace1 Proteins

Cat. No. Product Name Accession Purity
HY-P72843 BACE1 Protein, Mouse (HEK293, His) NP_035922.4 (T22-T457) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.87% Phase 3
HY-109055 Elenbecestat Inhibitor 99.82% Phase 3
HY-109052 Atabecestat Inhibitor 98.97% Phase 3
HY-114245 Se-Methylselenocysteine Inhibitor 99.95% Phase 1
HY-10472 LY2811376 Inhibitor 99.64% Phase 1
HY-13438 AZD3839 free base Inhibitor 99.97% Phase 1
HY-112157 PF-06751979 Inhibitor 99.57% Phase 1
HY-100182 BACE1-IN-1 Inhibitor 98.72% Phase 1

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13240 LY2886721 Inhibitor 99.72% Unkown
HY-N0226A Epiberberine chloride Inhibitor 98.68% Unkown
HY-15908 BCA Inhibitor 99.99% Unkown
HY-N1255 Scoulerine Inhibitor 99.99% Unkown
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-W015515 L-Citronellol Inhibitor 99.92% Unkown
HY-111383 LX2343 Inhibitor 99.80% Unkown
HY-N2215 Aloeresin D Inhibitor 99.51% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.78% Unkown
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-128594 BACE1-IN-4 Inhibitor / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128774 AM-6494 Inhibitor / Unkown
HY-112444 BACE1-IN-2 Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-N1255A Scoulerine hydrochloride Inhibitor / Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-147851 BACE1-IN-12 Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-W750970 2-Acetoxyacorenone Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-151348 BACE1-IN-11 Inhibitor / Unkown
HY-182786 MAO-B-IN-56 Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-11014 NB-216 Inhibitor / Unkown
HY-P3426 BACE1-IN-10 Inhibitor / Unkown
HY-P2713 OM99-2 Inhibitor / Unkown
HY-N13064 2,2′,4,4′-Tetrahydroxychalcone Inhibitor / Unkown
HY-139720 β-Secretase Inhibitor III Inhibitor / Unkown
HY-182429 NB-533 Inhibitor / Unkown
HY-114234A TAK-070 Free base Inhibitor / Unkown
HY-164956 TB-9 Inhibitor / Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-N8912 Ambrosin Inhibitor / Unkown
HY-114234 TAK-070 hydrochloride hydrate Inhibitor / Unkown
HY-N18261 8-Geranyloxy-5-methoxypsoralen Inhibitor / Unkown
HY-175661 SRI-22136 Inhibitor / Unkown
HY-126047 (S)-(-)-Anatabine Inhibitor / Unkown
HY-164958 TB-11 Inhibitor 98.71% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace1 NCBI NCBI:23621