2. Gene
  3. Bace1 - beta-secretase 1 Gene

Bace1 - beta-secretase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bace

Gene ID: 29392 | Gene type: protein coding

About Bace1

Primary_assembly 8: 46,142,116-46,165,876 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues.

Summary

Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (Beta-secretase 1). [provided by Alliance of Genome Resources, Apr 2022]

Bace1 Products(1)

mRNA Protein Name
NM_019204.2 NP_062077.1 beta-secretase 1 precursor

Bace1 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

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  • 501 a.a.
Protein Preferred Names Protein Names

beta-secretase 1

ASP2

asp 2

aspartyl protease 2

beta-site APP cleaving enzyme 1

beta-site amyloid precursor protein cleaving enzyme 1

memapsin-2

membrane-associated aspartic protease 2

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.82% Phase 3
HY-114245 Se-Methylselenocysteine Inhibitor ≥98.0% Phase 1
HY-10472 LY2811376 Inhibitor 99.89% Phase 1
HY-109052 Atabecestat Inhibitor 99.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-136742 BACE2-IN-1 Inhibitor 99.34% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-111383 LX2343 Inhibitor 99.80% Unkown
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-112444 BACE1-IN-2 Inhibitor / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128774 AM-6494 Inhibitor / Unkown
HY-128594 BACE1-IN-4 Inhibitor / Unkown
HY-151348 BACE1-IN-11 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-P3426 BACE1-IN-10 Inhibitor / Unkown
HY-139720 β-Secretase Inhibitor III Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace1 NCBI NCBI:23621
Mus musculus Bace1 NCBI NCBI:23821