Ace2 - angiotensin I converting enzyme 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 302668

Summary

Enables Carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]

Ace2 Products (1)

mRNA Protein Name
NM_001012006.2 NP_001012006.1 angiotensin-converting enzyme 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IDA
IDA: Inferred from direct assay
22595130 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15791205 RGD
Biological Process GO Annotation Evidence References Source
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
17977916 RGD
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
20703229 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20703229 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18223026 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiotensin-converting enzyme 2

  • ACE-related carboxypeptidase

  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

  • anigotensin-converting enzyme-related carboxypeptidase

  • renal angiotensin-converting enzyme 2

Ace2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ace2 Q5EGZ1 S Human SARS coronavirus P59594
Affinity Chrom
15791205
Cross
Ace2 Q5EGZ1 S Human SARS coronavirus P59594
FACS
15791205
Cross
Ace2 Q5EGZ1 S SARS-CoV-2 P0DTC2
SPR
34018203
Cross
Ace2 Q5EGZ1 S SARS-CoV-2 P0DTC2
FACS
34018203
Cross
Ace2 Q5EGZ1 S Pangolin coronavirus A0A6M3G9R1
FACS
34018203
Cross
Ace2 Q5EGZ1 S Pangolin coronavirus A0A6M3G9R1
SPR
34018203
Cross
Ace2 Q5EGZ1 S Pangolin coronavirus A0A6G6A1M4
FACS
34018203
Cross
Ace2 Q5EGZ1 S Pangolin coronavirus A0A6G6A1M4
SPR
34018203
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ace2 Proteins

Cat. No. Product Name Accession Purity
HY-P72809 ACE2 Protein, Rat (HEK293, His) Q5EGZ1 (Q18-T740) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13771 Ursodeoxycholic acid 99.94% Unkown
HY-B0260 Methylprednisolone 99.78% Yes
HY-12404 Diminazene aceturate 99.39% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99346 Regdanvimab Inhibitor 95.00% Unkown
HY-P9801 Anti-Spike-RBD mAb / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19414 MLN-4760 Inhibitor 99.93% Phase 2
HY-177332 SLC-391 Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99344 Bamlanivimab Inhibitor 99.97% Phase 4

Pre-clinical Phase

Bioactive Molecules (83)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14393 Emodin Inhibitor 99.25% Yes
HY-110066 (Z)-Guggulsterone 99.41% Unkown
HY-138113 Pyrrothiogatain Inhibitor 98.61% Unkown
HY-N0217 Benzoylaconine 99.92% Unkown
HY-N0639 Punicalin 99.88% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-120852 JG26 98.14% Unkown
HY-N2116 Ginkgolic acid C17:1 99.80% Unkown
HY-113478S Ursodeoxycholic acid-d4 99.52% Unkown
HY-B0260R Methylprednisolone (Standard) 98.90% Unkown
HY-P2536 Mca-Ala-Pro-Lys(Dnp)-OH 99.95% Unkown
HY-100450 BML-111 Inhibitor 98.87% Unkown
HY-P2222 DX600 Inhibitor 99.71% Unkown
HY-14393R Emodin (Standard) Inhibitor 98.84% Unkown
HY-163943 UNI418 Inhibitor 99.61% Unkown
HY-138067 SSAA09E2 Inhibitor 98.37% Unkown
HY-P2616A Mca-YVADAP-Lys(Dnp)-OH TFA Chemical 98.29% Unkown
HY-19414A (R)-MLN-4760 Inhibitor 99.51% Unkown
HY-126419 Kobophenol A Inhibitor 99.90% Unkown
HY-B0260S4 Methylprednisolone-d2 99.11% Unkown
HY-D1270 Direct Violet 1 Inhibitor / Unkown
HY-P2222A DX600 TFA Inhibitor 99.20% Unkown
HY-157154 MAT-POS-e194df51-1 Inhibitor 98.45% Unkown
HY-122445 Resorcinolnaphthalein Activator 99.87% Unkown
HY-179630 MS102 Inhibitor / Unkown
HY-B0260S Methylprednisolone-d3 / Unkown
HY-B0260S3 Methylprednisolone-d7 99.73% Unkown
HY-P3141 STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 95.28% Unkown
HY-P3142 NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ 96.51% Unkown
HY-P5407A HD5 TFA Inhibitor 95.30% Unkown
HY-P5642A Retrocyclin-101 TFA Inhibitor 96.69% Unkown
HY-RS00152 ACE2 Human Pre-designed siRNA Set A / Unkown
HY-W342283 Diminazene / Unkown
HY-B0260S6 Methylprednisolone-d3-1 / Unkown
HY-N12677 Isocannflavin B 99.9% Unkown
HY-RS00001 ACE2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14393S Emodin-d4 Inhibitor / Unkown
HY-121068 Bisoxatin Inhibitor / Unkown
HY-121421 Diniprofylline Inhibitor / Unkown
HY-149373 Garcinone B Inhibitor / Unkown
HY-149767 CMX990 Inhibitor 96.63% Unkown
HY-151497 Antimicrobial agent-10 Inhibitor / Unkown
HY-151501 Antimicrobial agent-11 Inhibitor / Unkown
HY-151502 Antimicrobial agent-12 Inhibitor / Unkown
HY-151900 SARS-CoV-2 Mpro-IN-4 Inhibitor / Unkown
HY-151901 SARS-CoV-2 Mpro-IN-5 Inhibitor / Unkown
HY-156441 SARS-CoV-2-IN-65 Inhibitor / Unkown
HY-156862 (+)-Chloroquine Activator / Unkown
HY-157966 SARS-CoV-2 3CLpro-IN-23 Inhibitor / Unkown
HY-158073 ML2006a4 Inhibitor / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-161844 Virapinib 98.01% Unkown
HY-168267 XH161-180 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-169977 CKP-25 Inhibitor / Unkown
HY-170767 SARS-CoV-2-IN-109 Inhibitor / Unkown
HY-174350 CK2-IN-15 Inhibitor / Unkown
HY-174373 SARS-CoV-2-IN-113 Inhibitor / Unkown
HY-178160 SARS-CoV-2 PLpro-IN-2 Inhibitor / Unkown
HY-179634 ASF-006 sodium Inhibitor / Unkown
HY-181066 ACE2-SP PPI-IN-1 Inhibitor / Unkown
HY-B0260S2 Methylprednisolone-d4 / Unkown
HY-N11608 3,5-Di-O-galloylshikimic acid Inhibitor / Unkown
HY-P11464 SARS-CoV-2 Spike receptor binding domain, RBD (371-394) / Unkown
HY-P2616 Mca-YVADAP-Lys(Dnp)-OH Chemical / Unkown
HY-P3258 SP-10 / Unkown
HY-P4546 Abz-Ser-Pro-3-nitro-Tyr / Unkown
HY-P5642 Retrocyclin-101 Inhibitor / Unkown
HY-P5827 SBP1 peptide / Unkown
HY-RS00154 ACER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-105801 Lydimycin Inhibitor / Unkown
HY-161070 Antiviral agent 46 Inhibitor / Unkown
HY-162550 Jobosic acid Inhibitor / Unkown
HY-162598 CET-1 Inhibitor / Unkown
HY-175325 SARS-CoV-2-IN-116 Inhibitor / Unkown
HY-175475 MolPort-010-778-422 Inhibitor / Unkown
HY-175697 Glycosyltransferase-IN-2 Inhibitor / Unkown
HY-180129 SARS-CoV-2-IN-120 Inhibitor / Unkown
HY-184485 MB-32 Inhibitor / Unkown
HY-N18500 (+)-Adlumidine Inhibitor / Unkown
HY-P5407 HD5 Inhibitor / Unkown
HY-RS16513 Ace2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W092987 Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate Inhibitor / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990180 Anti-Mouse NKG2A/C/E Antibody (20D5) Inhibitor 95.00% Unkown
HY-P990731 Canvircept / Unkown
HY-P990814 Anti-SARS-CoV-2 S protein Antibody (RBD epitope B, SARS2-34) Inhibitor / Unkown
HY-P990815 Anti-SARS-CoV-2 S protein Antibody (RBD epitope A, SARS2-01) Inhibitor / Unkown
HY-P991491 VIR-7229 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ace2 NCBI NCBI:59272