GAL - galanin and GMAP prepropeptide Gene
Also Known as ETL8; GALN; GLNN; GMAP; GAL-GMAP
Species: Homo sapiens
About GAL
This gene has 2 transcripts (splice variants), 187 orthologues and is associated with 1 phenotype. Biased expression in appendix (RPKM 6.0), colon (RPKM 2.3) and 5 other tissues.
Summary
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: Galanin and Galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess Antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
GAL Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_015973.5 | NP_057057.2 | galanin peptides preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables galanin receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
25691535 | GOA |
| enables neuropeptide hormone activity |
IDA
IDA: Inferred from direct assay
|
24517231 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23597562 | GOA |
| enables type 1 galanin receptor binding |
IDA
IDA: Inferred from direct assay
|
24517231 | GOA |
| enables type 2 galanin receptor binding |
IDA
IDA: Inferred from direct assay
|
24517231 | GOA |
| enables type 3 galanin receptor binding |
IDA
IDA: Inferred from direct assay
|
24517231 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cAMP-mediated signaling |
IDA
IDA: Inferred from direct assay
|
17982695 | GOA |
| involved in positive regulation of cortisol secretion |
IDA
IDA: Inferred from direct assay
|
17982695 | GOA |
| involved in positive regulation of large conductance calcium-activated potassium channel activity |
IDA
IDA: Inferred from direct assay
|
24602615 | GOA |
| involved in positive regulation of timing of catagen |
IDA
IDA: Inferred from direct assay
|
22329353 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
24517231 | GOA |
| involved in protein kinase A signaling |
IDA
IDA: Inferred from direct assay
|
17982695 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
9402244 | GOA |
| located in neuronal cell body |
IDA
IDA: Inferred from direct assay
|
23415787 | GOA |
GAL Protein Structure
Galanin: Galanin (33 - 61)
GMAP: Galanin message associated peptide (GMAP) (62 - 123)
- 0
- 100
- 123 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
galanin peptides |
|
GAL Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GAL | P22466 | ASPH | Homo sapiens | Q12797-6 | 32296183 | |
|
Intra
|
GAL | P22466 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GAL | P22466 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GAL | P22466 | SGTA | Homo sapiens | O43765 | 25416956 | |
|
Intra
|
GAL | P22466 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
GAL | P22466 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
GAL | P22466 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
GAL | P22466 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
GAL | P22466 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
GAL | P22466 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Recombinant GAL Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74132 | Galanin Protein, Human (HEK293, Fc) | P22466 (A20-S123) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700564 | Galanin Protein, Human (N-His, C-Myc) | P22466 (G44-S123) | ≥ 90%, as determined by reducing SDS-PAGE. |
GAL Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P89540 | Galanin Antibody (YA8884) | WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA | human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Epilepsy, Familial Temporal Lobe, 8 |
|
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| Acute Endometritis |
|
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| Hyperprolactinemia |
|
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| Acromegaly |
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| Anorexia Nervosa |
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| Status Epilepticus |
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| Paine Syndrome |
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| Epilepsy |
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| Insulinoma |
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| Anxiety |
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| Autonomic Peripheral Neuropathy |
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| Von Economo'S Disease |
|
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| Cholera |
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| Paraganglioma |
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| Hyperthyroidism |
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| Constipation |
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| Hypoglycemia |
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| Esophageal Atresia |
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| Panic Disorder |
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| Gastroenteritis |
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| Alcohol Use Disorder |
|
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| Brachial Plexus Lesion |
|
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| Trophoblastic Neoplasm |
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| Mononeuropathy |
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| Eating Disorder |
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| Complex Partial Epilepsy |
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| Mood Disorder |
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| Alzheimer Disease, Familial, 1 |
|
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| Type 2 Diabetes Mellitus |
|
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| Major Depressive Disorder |
|
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| Autism Spectrum Disorder |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Alcohol Dependence |
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| Diabetes Mellitus |
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| Autism |
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| Congenital Central Hypoventilation Syndrome |
|
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| Hirschsprung Disease 1 |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | GAL | MGD | MGI:95637 |
| Rattus norvegicus | GAL | RGD | RGD:61954 |
| Bos taurus | GAL | VGNC | VGNC:29212 |
| Macaca mulatta | GAL | VGNC | VGNC:72866 |
| Felis catus | GAL | VGNC | VGNC:62435 |
| Canis familiaris | GAL | VGNC | VGNC:41075 |
| Others | GAL | NCBI |