GAL - galanin and GMAP prepropeptide Gene

Homo sapiens

Also known as ETL8; GALN; GLNN; GMAP; GAL-GMAP

Gene ID: 51083 | Gene type: protein coding

About GAL

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,684,544-68,691,175 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and is associated with 1 phenotype. Biased expression in appendix (RPKM 6.0), colon (RPKM 2.3) and 5 other tissues.

Summary

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: Galanin and Galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess Antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

GAL Products(1)

mRNA	Protein	Name
NM_015973.5	NP_057057.2	galanin peptides preproprotein

GAL Protein Structure

Galanin

GMAP

0
100
123 a.a.

Protein Preferred Names

Protein Names

galanin peptides

galanin prepropeptide

Recombinant GAL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74132	Galanin Protein, Human (HEK293, Fc)	P22466 (A20-S123)	≥95%
HY-P700564	Galanin Protein, Human (N-His, C-Myc)	P22466 (G44-S123)	≥95%

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 8

ETL8	Familial Temporal Lobe Epilepsy 8
Epilepsy, Temporal Lobe, Familial, Type 8

Acute Endometritis

Hyperprolactinemia

Chiari-Frommel Syndrome	Hyperprolactinaemia
Familial Hyperprolactinemia	HPRL
Pregnancy-Related A-G Syndrome	Familial Isolated Prolactin Receptor Deficiency

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Status Epilepticus

Grand Mal Status Epilepticus	Grand Mal Status
Gcse	Generalized Convulsive Status Epilepticus
Se	Epilepsy With Status Epilepticus

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Autonomic Peripheral Neuropathy

Peripheral Autonomic Nervous System Diseases

Von Economo'S Disease

Encephalitis Lethargica	Von Economo Encephalitis
Von Economo Disease

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Paraganglioma

Chemodectoma	Glomus Body Tumor
Paragangliomas	Carotid Body Paraganglioma
Extra-Adrenal Paraganglioma

Hyperthyroidism

Overactive Thyroid

Constipation

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Mononeuropathy

Mononeuropathies

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Complex Partial Epilepsy

Epilepsy, Complex Partial	Complex Partial Epileptic Seizure
Epilepsy, Psychomotor	Psychomotor Epilepsy

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diabetes Mellitus

Diabetes

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14929A	Migalastat hydrochloride	Inhibitor	≥99.0%	Yes
HY-14929	Migalastat	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114440	Belapectin		92.79%	Phase 3
HY-147041	Selvigaltin	Inhibitor	98.72%	Phase 2
HY-100717	HT-2157	Antagonist	≥98.0%	Phase 2
HY-136527	BMS-986251		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (86)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114409	GB1107	Inhibitor	99.90%	Unkown
HY-15934	X-GAL		99.88%	Unkown
HY-130208	Thiodigalactoside	Inhibitor	≥99.0%	Unkown
HY-137276	5-Bromo-3-indolyl β-D-galactopyranoside		99.40%	Unkown
HY-10678	BMS-687453	Agonist	98.58%	Unkown
HY-118135	4-Methylumbelliferyl-α-D-galactopyranoside		99.76%	Unkown
HY-N7088	Raffinose		≥98.0%	Unkown
HY-155175	TIM-3-IN-2	Inhibitor	99.36%	Unkown
HY-P2869	β-Galactosidase, E. coli		/	Unkown
HY-101422	GAL-021	Inhibitor	99.89%	Unkown
HY-103536A	Galnon TFA	Agonist	99.15%	Unkown
HY-123148	IMB-808	Agonist	99.85%	Unkown
HY-146808	Galectin-3 antagonist 1	Antagonist	99.77%	Unkown
HY-P0232	Fmoc-Thr[GalNAc(Ac)3-α-D]-OH		98.36%	Unkown
HY-P1131	M617	Agonist	99.54%	Unkown
HY-P1131A	M617 TFA		99.91%	Unkown
HY-W039911	4-Nitrophenyl α-D-galactopyranoside		98.53%	Unkown
HY-104004	Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH		98.60%	Unkown
HY-P1132A	Galanin (1-29)(rat, mouse) TFA	Agonist	99.67%	Unkown
HY-105327	P11149	Inhibitor	99.23%	Unkown
HY-114522	X-alpha-Gal		/	Unkown
HY-E70033	D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)		/	Unkown
HY-P1135	M1145	Agonist	99.54%	Unkown
HY-101422A	GAL-021 sulfate	Inhibitor	/	Unkown
HY-139562	BMS-986318	Agonist	/	Unkown
HY-103536	Galnon	Agonist	/	Unkown
HY-104004A	Fmoc-Ser(O-β-D-GalNAc(OAc)3)-OH		/	Unkown
HY-111366	CD12681	Agonist	/	Unkown
HY-112752	Gal-C4-Chol		/	Unkown
HY-121542	PPARδ agonist 10	Agonist	/	Unkown
HY-130570	β-Gal-NONOate	Inhibitor	/	Unkown
HY-132239	5-Bromo-6-chloro-3-indolyl β-D-Galactopyranoside contains ca. 10% Ethyl Acetate		/	Unkown
HY-135376	Atorvastatin methyl ester		/	Unkown
HY-135378	Atorvastatin ethyl ester		/	Unkown
HY-141488	Lacto-N-biose I		/	Unkown
HY-144313	Galectin-3-IN-2	Inhibitor	/	Unkown
HY-147112	MNP-GAL		/	Unkown
HY-147865	Apoptosis inducer 8		/	Unkown
HY-151514	Antituberculosis agent-5	Inhibitor	99.76%	Unkown
HY-153101	Gal-G2-CNP		/	Unkown
HY-156996	AGI-134		/	Unkown
HY-163078	C2-Gal-Dox		/	Unkown
HY-163405	Galectin-3-IN-3	Inhibitor	/	Unkown
HY-D1510	4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside		/	Unkown
HY-E70052	alpha-1,3-Galactosyltransferase (a1,3GalT)		/	Unkown
HY-E70053	alpha-1,3-Galactosyltransferase (GTB)		/	Unkown
HY-E70136	Endo-β-Galactosidase		/	Unkown
HY-N10527	Isoglobotetraose		/	Unkown
HY-N12016	Fulvotomentoside B		/	Unkown
HY-N9134	5-O-Methylgenistein	Inhibitor	/	Unkown
HY-P0262A	Galantide TFA	Antagonist	98.09%	Unkown
HY-P1132	Galanin (1-29)(rat, mouse)	Agonist	/	Unkown
HY-P1135A	M1145 TFA	Agonist	/	Unkown
HY-P1560	Allergen Gal d 4 (46-61), chicken	Inhibitor	/	Unkown
HY-P1723A	Spexin TFA	Agonist	/	Unkown
HY-P5896	Ala5-Galanin (2-11)	Agonist	/	Unkown
HY-RS05238	GAL Human Pre-designed siRNA Set A		/	Unkown
HY-RS05239	GAL3ST1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS05240	GAL3ST4 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13846	ST3GAL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13847	ST3GAL2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13848	ST3GAL3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13849	ST3GAL4 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13850	ST3GAL5 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13851	ST3GAL6 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13852	ST6GAL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13853	ST6GAL2 Human Pre-designed siRNA Set A		/	Unkown
HY-W127769	Rose-β-D-Gal		/	Unkown
HY-W145524	Gal[246Bn,3All]-β-SPh		/	Unkown
HY-W145529	GalNAcβ(1-3)Galα(1-4)Galβ(1-4)Glc-β-pNP		/	Unkown
HY-W145538	Nonasaccharide Glc4Xyl3Gal2		/	Unkown
HY-W145540	Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP		/	Unkown
HY-W145556	Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP		/	Unkown
HY-W145558	Galβ(1-4)Glc-β-MP		/	Unkown
HY-W145559	Gal[236Bn]β(1-4)Glc[236Bn]-β-MP		/	Unkown
HY-W145561	Neu5Acα(2-3)Galβ MP glycoside		/	Unkown
HY-W145594	Gal[26Bn]β(1-4)Glc[236Bn]-β-MP		/	Unkown
HY-W145607	Galβ(1-3)GalNAc-β-pNP		/	Unkown
HY-W145609	Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP		/	Unkown
HY-W145620	Gal[246Bn]β(1-4)Glc[236Bn]-β-MP		/	Unkown
HY-W145621	Gal[2346Bn]-β-SPh		/	Unkown
HY-W145622	Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP		/	Unkown
HY-W145655	Gal-β1,3-GalNAc-α1-OBn		/	Unkown
HY-W145663	Gal-β1,3-GalNAc-β-OMe		/	Unkown
HY-W154295	Purple-β-D-Gal		/	Unkown
HY-144312	Galectin-3-IN-1	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GAL	MGD	MGI:95637
Rattus norvegicus	GAL	RGD	RGD:61954
Bos taurus	GAL	VGNC	VGNC:29212
Macaca mulatta	GAL	VGNC	VGNC:72866
Felis catus	GAL	VGNC	VGNC:62435
Canis familiaris	GAL	VGNC	VGNC:41075
Macaca fascicularis	GAL	NCBI
Others	GAL	NCBI