PGC - progastricsin Gene

Also Known as PEPC; PGII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5225

About PGC

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,736,711-41,747,397 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 7385.5).

Summary

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

PGC Products (2)

mRNA Protein Name
NM_001166424.2 NP_001159896.1 gastricsin isoform 2 preproprotein
NM_002630.4 NP_002621.1 gastricsin isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
12759353 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of antibacterial peptide production IMP
IMP: Inferred from mutant phenotype
12759353 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12759353 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGC Protein Structure

A1_Propeptide

A1_Propeptide: A1 Propeptide (18 - 46)

Asp

Asp: Eukaryotic aspartyl protease (72 - 387)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

gastricsin

  • pepsin C

Recombinant PGC Proteins

Cat. No. Product Name Accession Purity
HY-P77131 Pepsinogen C/PGC Protein, Human (His) P20142-1/NP_002621.1 (I153-I239) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77132 Pepsinogen C/PGC Protein, Human (HEK293, His) P20142-1/NP_002621.1 (A17-A388) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastritis

  • Acute Gastric Mucosal Erosion

  • Erosive Gastritis

  • Erosive Gastropathy

  • Gastritis Erosive

  • Idiopathic Erosive/Hemorrhagic Gastritis

  • Inflammation Of Gastric Mucosa

  • Gastroduodenitis

  • Gastritis Nos

  • Noninfectious Gastroenteritis

  • Nonbacterial Gastroenteritis Of Infant

  • Acute Gastric Infection

  • Acute Simple Gastritis

  • Chronic Antral Gastritis

  • Chronic Fundal Gastritis

  • Chronic Simple Gastritis

  • Acute Gastroduodenitis

  • Acute Antral Gastritis

  • Acute Erosive Gastritis

  • Bile Reflux Gastritis

  • Gastritis Due To Biliary Reflux
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia

  • HH14

  • Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia
Gastroesophageal Reflux

  • Gastroesophageal Reflux Disease

  • Gerd

  • GER

  • Gastroesophageal Reflux, Pediatric

  • Acid Reflux

  • Gastresophageal Reflux

  • Gastro-Esophageal Reflux

  • Gerd - Gastro-Esophageal Reflux Disease
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0378 D-Mannitol 99.93% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0378R D-Mannitol (Standard) 99.96% Phase 4
HY-P3624 Cenderitide Agonist 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-17538 ZLN005 Activator 99.92% Unkown
HY-101491 SR-18292 Inhibitor 99.87% Unkown
HY-P2048 MOTS-c (human) 99.90% Unkown
HY-P2048A MOTS-c(human) acetate Activator 99.74% Unkown
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-113960 ERRα antagonist-1 Antagonist 99.57% Unkown
HY-N3686 D-Arabitol Activator 99.92% Unkown
HY-114557 NSC 90469 99.41% Unkown
HY-165126 Schizophyllan / Unkown
HY-N0859 Schisanhenol Inhibitor 99.99% Unkown
HY-P5763 Phoenixin-20 99.66% Unkown
HY-N3307 (+)-Medioresinol 99.13% Unkown
HY-N0378S2 D-Mannitol-13C6 99.96% Unkown
HY-P3455 Ac-SVVVRT-NH2 Modulator 98.68% Unkown
HY-N0378S3 D-Mannitol-2-13C 99.95% Unkown
HY-N0378S1 D-Mannitol-13C 99.9% Unkown
HY-136855 MitoPBN 95.00% Unkown
HY-N7439 Mogroside VI B Activator 98.97% Unkown
HY-119790 Palmitoyllactic acid Agonist 99.89% Unkown
HY-130479 AdipoR agonist 1 ≥98.0% Unkown
HY-126351 ERRα ligand 2 Antagonist 99.36% Unkown
HY-17538S ZLN005-d4 Activator 99.52% Unkown
HY-N0378S D-Mannitol-d8 / Unkown
HY-W073128 Perfluorotetradecanoic acid 98.0% Unkown
HY-Y1207 Ethoxybenzene 99.91% Unkown
HY-114557R NSC 90469 (Standard) / Unkown
HY-120510 PF-04308515 / Unkown
HY-125535 OSU-53 / Unkown
HY-128895A KL1333 hydrochloride Modulator / Unkown
HY-138443A BF-175 / Unkown
HY-159928 Neuroprotective agent 8 Inhibitor / Unkown
HY-171722 Ascr#10 Activator / Unkown
HY-17538A ZLN005 hydrochloride Activator / Unkown
HY-178413S D-Mannitol-d4 / Unkown
HY-179498 ROCK2-IN-13 / Unkown
HY-180398 PA-082 Modulator / Unkown
HY-183094 AM73 / Unkown
HY-183095 AM79 / Unkown
HY-183096 AM31 / Unkown
HY-183097 AM89 / Unkown
HY-186011 CPAG-1 Activator / Unkown
HY-N0378AGL D-Mannitol, M200 (GMP Like) / Unkown
HY-N0378BGL D-Mannitol, M100 (GMP Like) / Unkown
HY-N0378S4 D-Mannitol-d2 / Unkown
HY-N0378S5 D-Mannitol-d1 / Unkown
HY-N0378S6 D-Mannitol-13C,d2 / Unkown
HY-N0859R Schisanhenol (Standard) Inhibitor / Unkown
HY-N12011 11-Oxoisomogroside V Activator / Unkown
HY-N3686S D-Arabitol-13C Activator / Unkown
HY-N3686S1 D-Arabitol-13C-1 Activator / Unkown
HY-N3686S2 D-Arabitol-13C-2 Activator / Unkown
HY-P10720 C-Type Natriuretic Peptide (1-53), Porcine, Rat,mouse / Unkown
HY-P5763A Phoenixin-20 TFA / Unkown
HY-RS10380 PGC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101491S SR-18292-d9 / Unkown
HY-125629 Primordazine B Agonist / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS17091 Pgc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23535 Pgc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PGC RGD RGD:3943
Felis catus PGC VGNC VGNC:68812
Bos taurus PGC VGNC VGNC:32785
Mus musculus PGC MGD MGI:98909
Canis familiaris PGC VGNC VGNC:57228
Macaca mulatta PGC VGNC VGNC:83442
Others PGC NCBI