BRD9 - bromodomain containing 9 Gene

Also Known as PRO9856; SMARCI2; LAVS3040

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65980

About BRD9

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:863,735-892,801 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 6.5), lymph node (RPKM 4.8) and 25 other tissues.

Summary

Enables lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2022]

BRD9 Products (25)

mRNA Protein Name
XM_047417603.1 XP_047273559.1 bromodomain-containing protein 9 isoform X5
NR_134296.1
XM_024446198.2 XP_024301966.1 bromodomain-containing protein 9 isoform X9
XM_047417606.1 XP_047273562.1 bromodomain-containing protein 9 isoform X12
NM_023924.5 NP_076413.3 bromodomain-containing protein 9 isoform 1
NM_001375877.1 NP_001362806.1 bromodomain-containing protein 9 isoform 7
XM_024446199.2 XP_024301967.1 bromodomain-containing protein 9 isoform X7
XM_047417602.1 XP_047273558.1 bromodomain-containing protein 9 isoform X4
NM_001375863.1 NP_001362792.1 bromodomain-containing protein 9 isoform 6
XM_047417605.1 XP_047273561.1 bromodomain-containing protein 9 isoform X10
XM_024446196.2 XP_024301964.1 bromodomain-containing protein 9 isoform X3
NM_001317951.2 NP_001304880.1 bromodomain-containing protein 9 isoform 3
NM_001375862.1 NP_001362791.1 bromodomain-containing protein 9 isoform 5
NM_001009877.3 NP_001009877.2 bromodomain-containing protein 9 isoform 2
XM_047417600.1 XP_047273556.1 bromodomain-containing protein 9 isoform X1
NM_001375878.1 NP_001362807.1 bromodomain-containing protein 9 isoform 8
XR_007058631.1
XM_047417601.1 XP_047273557.1 bromodomain-containing protein 9 isoform X2
XM_006714494.4 XP_006714557.1 bromodomain-containing protein 9 isoform X11
XM_024446195.2 XP_024301963.1 bromodomain-containing protein 9 isoform X1
XM_024446200.2 XP_024301968.1 bromodomain-containing protein 9 isoform X8
XM_047417604.1 XP_047273560.1 bromodomain-containing protein 9 isoform X6
NR_164742.1
NM_001375879.1 NP_001362808.1 bromodomain-containing protein 9 isoform 9
NM_001375861.1 NP_001362790.1 bromodomain-containing protein 9 isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
22464331 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
23644491 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD9 Protein Structure

Bromodomain

Bromodomain: Bromodomain (147 - 228)

DUF3512

DUF3512: Domain of unknown function (DUF3512) (268 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 9

  • rhabdomyosarcoma antigen MU-RMS-40.8

  • sarcoma antigen NY-SAR-29

BRD9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
BRD9 Q9H8M2 CATIP Homo sapiens Q7Z7H3
Y2H Array
25416956
Intra
BRD9 Q9H8M2 CATIP Homo sapiens Q7Z7H3
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nut Midline Carcinoma

  • Nuclear Protein In Testis Midline Carcinoma

  • Nmc
Chronic Dacryoadenitis
Sarcoma, Synovial

  • Synovial Sarcoma

  • Synovialosarcoma

  • Synovial Cell Sarcoma

  • Sarcoma Synovial
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Rhabdoid Cancer

  • Rhabdoid Tumor

  • Malignant Rhabdoid Tumor

  • Malignant Rhabdoid Tumour

  • Rhabdoid Sarcoma

  • Rhabdoid Tumor Predisposition Syndrome 1

  • Rhabdoid Tumor Predisposition Syndrome 2

  • Atypical Teratoid Rhabdoid Tumor

  • Brain Tumor, Posterior Fossa, Of Infancy, Familial

  • Atypical Teratoid/Rhabdoid Tumor
Synovium Cancer

  • Malignant Tumor Of Synovium

  • Synovial Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-153367 FHD-609 Inhibitor 98.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (51)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100351 BI-7273 Inhibitor 99.75% Unkown
HY-145925B CFT8634 Inhibitor 98.10% Unkown
HY-114322 VZ185 Inhibitor 99.95% Unkown
HY-100352 BI-9564 Inhibitor 98.96% Unkown
HY-117690 dBRD9 Degrader 99.75% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-100517 TP-472 Inhibitor 99.54% Unkown
HY-149420 BRD7-IN-2 Inhibitor 99.29% Unkown
HY-148739 dBRD 9-A Degrader 99.50% Unkown
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor 99.16% Unkown
HY-107477 GSK8573 99.53% Unkown
HY-159579 CW-3308 99.43% Unkown
HY-123621 GNE-375 Inhibitor 99.93% Unkown
HY-145403 PROTAC BRD9 Degrader-4 Degrader 99.06% Unkown
HY-155361 PROTAC BRD9 Degrader-7 Degrader 99.29% Unkown
HY-49393 BRD9 ligand-6 97.51% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-114205A TP-238 hydrochloride Inhibitor ≥99.0% Unkown
HY-116227 (2S,3R)-LP99 Inhibitor 99.4% Unkown
HY-117690A dBRD9 dihydrochloride Degrader 99.91% Unkown
HY-145947 PROTAC BRD9 Degrader-5 Degrader / Unkown
HY-182082 XYD270 / Unkown
HY-182766 AMX-883 Degrader / Unkown
HY-111905A BRD7-IN-1 free base Inhibitor / Unkown
HY-178345 ZZ7-23-022 Degrader / Unkown
HY-182084 BRD9 ligand-12 Ligand / Unkown
HY-153632 PROTAC BRD9 Degrader-6 Degrader 98.19% Unkown
HY-143270 PROTAC BRD9-binding moiety 5 / Unkown
HY-145925C (S,R)-CFT8634 Inhibitor / Unkown
HY-184210 XYD224 Degrader / Unkown
HY-163810 BRD9 Degrader-3 Degrader / Unkown
HY-181949 PROTAC BRD9 Degrader-10 / Unkown
HY-184211 BRD9 ligand-14 Ligand / Unkown
HY-114205 TP-238 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-123616 BI 7271 Degrader / Unkown
HY-181951 PROTAC BRD9 Degrader-11 Degrader / Unkown
HY-168695 BRD9 ligand-7 Ligand / Unkown
HY-163811 BRD9 Degrader-4 Inhibitor / Unkown
HY-162651 PROTAC BRD9 Degrader-8 Degrader / Unkown
HY-150872 BRD9 ligand-3 Ligand / Unkown
HY-150797 QA-68 Inhibitor / Unkown
HY-170314 EA-89 Degrader / Unkown
HY-163809 BRD9 Degrader-2 Degrader / Unkown
HY-177729 PROTAC BRD9 Degrader-9 Degrader / Unkown
HY-159596 Naphthyridin-Me-dimethoxybenzene-COOH / Unkown
HY-181952 BRD9 ligand-11 Ligand / Unkown
HY-169988 BRD9 ligand-5 Inhibitor / Unkown
HY-181950 BRD9 ligand-10 Ligand / Unkown
HY-175915 BRD9 ligand-13 / Unkown
HY-107446 BI-7273 acid Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BRD9 VGNC VGNC:26561
Felis catus BRD9 VGNC VGNC:60171
Rattus norvegicus BRD9 RGD RGD:1307359
Macaca mulatta BRD9 VGNC VGNC:70386
Mus musculus BRD9 MGD MGI:2145317
Canis familiaris BRD9 VGNC VGNC:49822
Others BRD9 NCBI