Cat. No.: HY-B2035

Pretilachlor

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Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish.

For research use only. We do not sell to patients.

Purity: 99.25%
CAS No.: 51218-49-6
Formula: C₁₇H₂₆ClNO₂
Molecular Weight:311.85

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pretilachlor Chemical Structure

CAS No.: 51218-49-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Caspase 3

Caspase 9

Aromatase

IL-8

IL-1β

All Caspase Isoforms :

All Cytochrome P450 Isoforms :

All Interleukin Related Isoforms :

In Vivo

Pretilachlor (50-200 μg/L; aqueous exposure; continuous; 96 hours) induces endocrine disruption, immunotoxicity, oxidative stress, and apoptosis in developing zebrafish embryos, with significant alterations in gene transcription, protein levels, and enzyme activities across multiple physiological pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AB strain (embryos from adult females with average weight 0.93 g, males with average weight 0.65 g)^[1]
Dosage:

50 μg/L, 100 μg/L, 200 μg/L
Administration:

aqueous exposure; continuous; 96 hours
Result:

Upregulated VTG1 mRNA by 3.45-fold (50 μg/L), 2.74-fold (100 μg/L) and 2.43-fold (200 μg/L).
Upregulated CYP19a mRNA by 4.29-fold (50 μg/L); upregulated CYP19b mRNA by 3.29-fold (50 μg/L) and raised its level at 200 μg/L.
Elevated ERα mRNA at 200 μg/L; suppressed ERβ1 mRNA at 100 μg/L and 200 μg/L.
Raised TRα mRNA at 50 μg/L and 200 μg/L; upregulated Dio2 mRNA by 1.5-fold (50 μg/L).
Boosted VTG protein contents and aromatase activity at 50 μg/L and 100 μg/L.
Elevated T3 content at 100 μg/L; increased T4 content at 50 μg/L and 100 μg/L.
Suppressed CXCL-C1C mRNA across all tested concentrations.
Reduced IL-1β mRNA to 0.172-fold (50 μg/L), 0.350-fold (100 μg/L) and 0.400-fold (200 μg/L) in a dose-dependent manner.
Lowered IL-8 mRNA at 100 μg/L.
Upregulated CAT and Cu/Zn-SOD mRNA at 50 μg/L; upregulated GPX mRNA at 200 μg/L.
Increased CAT protein contents at 50 μg/L and 100 μg/L; enhanced CAT activity at 100 μg/L.
Raised SOD protein content at 50 μg/L; elevated GPX protein contents at 50 μg/L and 200 μg/L.
Elevated ROS levels at all tested concentrations.
Upregulated P53 mRNA at 50 μg/L and 200 μg/L; upregulated Mdm2 mRNA at 50 μg/L; upregulated Bbc3 mRNA by 2.08-fold (200 μg/L).
Enhanced Caspase3 activity at 100 μg/L and 200 μg/L; increased Caspase9 activity at 100 μg/L.

Chemical Information

CAS No. 51218-49-6
Appearance Liquid (Density: 1.074±0.06 g/cm³)
Molecular Weight 311.85
Formula C₁₇H₂₆ClNO₂
Color Colorless to light yellow
SMILES

O=C(N(C1=C(CC)C=CC=C1CC)CCOCCC)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (641.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2067 mL

16.0333 mL

32.0667 mL

5 mM

0.6413 mL

3.2067 mL

6.4133 mL

10 mM

0.3207 mL

1.6033 mL

3.2067 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiang J, et al. Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Environ Toxicol Pharmacol. 2016;42:125-134. [Content Brief]

[2]. Soni R, et al. Acute toxicity and behavioural responses in Clarias batrachus (Linnaeus) exposed to herbicide pretilachlor. Heliyon. 2018 Dec;4(12):e01090.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2067 mL	16.0333 mL	32.0667 mL	80.1667 mL
	5 mM	0.6413 mL	3.2067 mL	6.4133 mL	16.0333 mL
	10 mM	0.3207 mL	1.6033 mL	3.2067 mL	8.0167 mL
	15 mM	0.2138 mL	1.0689 mL	2.1378 mL	5.3444 mL
	20 mM	0.1603 mL	0.8017 mL	1.6033 mL	4.0083 mL
	25 mM	0.1283 mL	0.6413 mL	1.2827 mL	3.2067 mL
	30 mM	0.1069 mL	0.5344 mL	1.0689 mL	2.6722 mL
	40 mM	0.0802 mL	0.4008 mL	0.8017 mL	2.0042 mL
	50 mM	0.0641 mL	0.3207 mL	0.6413 mL	1.6033 mL
	60 mM	0.0534 mL	0.2672 mL	0.5344 mL	1.3361 mL
	80 mM	0.0401 mL	0.2004 mL	0.4008 mL	1.0021 mL
	100 mM	0.0321 mL	0.1603 mL	0.3207 mL	0.8017 mL

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Pretilachlor

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Antidepressant Compound Library

Human Metabolite Library

Chemokine Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

All Caspase Isoforms

All Cytochrome P450 Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Pretilachlor Related Classifications

HY-B2035 Related Classifications