製品番号: HY-W040055

Neopterin

(別名: D-(+)-Neopterin; D-erythro-Neopterin; L-ネオプテリン)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.95%
CAS 番号: 2009-64-5
分子式: C₉H₁₁N₅O₄
分子量:253.21

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Neopterin 構造式

CAS 番号: 2009-64-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

NF-κB アイソフォーム固有の製品をすべて表示 :

Raf アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

PPAR アイソフォーム固有の製品をすべて表示 :

Src アイソフォーム固有の製品をすべて表示 :

体外実験

Neopterin (200 nM; 4-48 h) inhibits cell proliferation, reduces the mRNA and protein expression of inflammatory factors such as MCP-1, ICAM-1, and VCAM-1 induced by TNF-α, and reduces monocyte adhesion in human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs)^[1].
Neopterin (200 nM; 7 d+19 h) inhibits oxidized low-density lipoprotein (oxLDL)-induced foam cell formation in human monocyte-derived macrophages (HMDMs), downregulates CD36 expression, upregulates ABCA1, ABCG1, and LXR-α protein levels, and promotes cholesterol efflux^[1].
Neopterin (200 nM; 24-48 h) inhibits angiotensin II-induced cell migration and proliferation, downregulates the c-Src/Raf-1/ERK1/2 signaling pathway, and upregulates the expression of fibronectin, MMP-2, and TIMP-2 proteins in human aortic smooth muscle cells (HASMCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human aortic endothelial cells (HAECs), human umbilical vein endothelial cells (HUVECs), human aortic smooth muscle cells (HASMCs)
Concentration:

5-200 nM
Incubation Time:

48 h
Result:

Significantly suppressed proliferation in HAECs and HUVECs in a concentration-dependent manner, with maximal inhibition at 200 nM.
Reduced cell viability, with the most pronounced effect at 200 nM in HASMCs.

体内実験

Neopterin (1.2 μmol/kg; ip; once a day; 4 weeks) significantly slows the progression of aortic atherosclerotic lesions, reduces plaque area and monocyte/macrophage and CD8+ T cell infiltration, and reduces the content of vascular smooth muscle cells and plasma PTX-3 levels in apolipoprotein E-deficient (Apoe-) mice[1].
Neopterin (0.4-4.0 mg/kg; iv; single dose, tested for 21 days) causes a decrease in the number of bone marrow erythroid progenitors (BFU-E, CFU-E) and an increase in the number of myeloid progenitors (CFU-GM) in young mice in the aging-associated stromal cell damage model of male senescence-accelerated mice, while the number of erythroid progenitors decreases in aged mice, but serum erythropoietin (Epo) concentrations did not decrease.^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 Apoe^- mice (27-29 g, 17-21 weeks old) with diet-induced atherosclerosis^[1]
Dosage:

1.2 μmol/kg
Administration:

Intraperitoneal injection daily for 4 weeks
Result:

Aortic atherosclerotic lesion area and cross-sectional plaque size at the aortic root were reduced by 35% and 17%, respectively, compared to vehicle-treated controls.
Immunohistochemistry showed decreased infiltration of monocyte/macrophages (MOMA-2⁺ cells) and CD8⁺ T cells in atheromatous plaques.
Vascular smooth muscle cell (α-SMA⁺) content and expression of pro-inflammatory markers MCP-1 and PTX-3 in plaques were significantly lower in neopterin-treated mice.
Plasma PTX-3 levels, a marker of plaque instability, were reduced by 30% compared to controls.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2009-64-5
性状 Solid
分子量 253.21
分子式 C₉H₁₁N₅O₄
Color White to off-white
SMILES

OC1=C2C(N=CC([C@H](O)[C@H](O)CO)=N2)=NC(N)=N1
別名

D-(+)-Neopterin; D-erythro-Neopterin; L-ネオプテリン
Structure Classification
- Others
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Chem Biol Interact

Cinnamic acid induces neurodevelopmental defects via PPARγ signaling in zebrafish. [Abstract]

2026 Mar 25:427:111929. PMID: 41548734

溶剤 & 溶解度

体外:

DMSO : 4.17 mg/mL (16.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9493 mL

19.7465 mL

39.4929 mL

5 mM

0.7899 mL

3.9493 mL

7.8986 mL

10 mM

0.3949 mL

1.9746 mL

3.9493 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shirai R, et al. Neopterin Counters Vascular Inflammation and Atherosclerosis. J Am Heart Assoc. 2018 Feb 2;7(3):e007359. [Content Brief]

[2]. Aisaki K, et al. Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment. Exp Biol Med (Maywood). 2012 Mar;237(3):279-86. [Content Brief]

[3]. Fuchs D, et al. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci. 1992;29(3-4):307-41. [Content Brief]

[4]. Sucher R, et al. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010 Jan 1;287(1):13-22. [Content Brief]

[5]. Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9493 mL	19.7465 mL	39.4929 mL	98.7323 mL
	5 mM	0.7899 mL	3.9493 mL	7.8986 mL	19.7465 mL
	10 mM	0.3949 mL	1.9746 mL	3.9493 mL	9.8732 mL
	15 mM	0.2633 mL	1.3164 mL	2.6329 mL	6.5822 mL

Keywords

Neopterin

1 Cited Publications

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Neopterin

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MedChemExpress（MCE）の使用を引用している文献 Neopterin

NF-κB アイソフォーム固有の製品をすべて表示

Raf アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

PPAR アイソフォーム固有の製品をすべて表示

Src アイソフォーム固有の製品をすべて表示

生物活性

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Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

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