製品番号: HY-N2907

Atranorin

(別名: アトラノリン)

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Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.68%
CAS 番号: 479-20-9
分子式: C₁₉H₁₈O₈
分子量:374.34

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Atranorin 構造式

CAS 番号: 479-20-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

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Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	>5 μM Compound: 4	Antiproliferative activity against human HaCaT cells Antiproliferative activity against human HaCaT cells	[PMID: 10395495]
PMNL	IC₅₀	6 μM Compound: 4	Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells	[PMID: 10395494]

体外実験

Atranorin (0.01-10 μg/mL; 3 h) protects SH-SY5Y cells from H₂O₂-induced cytotoxicity^[1].
Atranorin (24 h) inhibits the expression of PD-L1 and TIM-3 in THP-1, KG-1 and Mono-Mac-1 cells, with the mechanism related to AKT pathway inhibition^[2].
Atranorin (0-10 μg/mL; 24-72 h) suppresses the migration and invasion of A549 cells. The mechanism involves the inhibition of AP-1, Wnt, STAT pathways and RhoGTPase activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Atranorin (10 mg/kg; intraperitoneal injection; once every 3 days; 2 weeks) exhibits antitumor activity in a mouse lung cancer model^[3].
Atranorin (1-5%; topical application as an ointment; once daily; 3-21 days) promotes wound healing in a rat excisional wound model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice aged 8 weeks old treated LLC cells^[3]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection; once every 3 days; 2 weeks
Result:

Significantly reduced tumor volume, tumor weight, and nuclear Ki-67 immunoreactivity.
Downregulated target genes (e.g., KITENIN, STAT, c-myc) in tumor tissues.

Animal Model:

Male Wistar rats (220-260 g) with full-thickness excisional wounds created by an 8 mm biopsy punch on the back^[4]
Dosage:

1% and 5% in ointment form
Administration:

Topical application as an ointment; once daily; 3, 7, 14 and 21 days
Result:

Reduced wound areas significantly on days 3, 7, and 14 (particularly with 5% atranorin).
Induced earlier granulation tissue formation with increased fibroblastic and vascular components.
Improved collagen deposition and organization (with more type I collagen and dense interlaced arrangement in the 5% group).
Modulated myofibroblasts differentiation (reduced early myofibroblasts in the 5% group and promoted timely apoptosis by day 21).

化学情報

CAS 番号 479-20-9
性状 Solid
分子量 374.34
分子式 C₁₉H₁₈O₈
Color White to off-white
SMILES

O=C(OC1=CC(C)=C(C(OC)=O)C(O)=C1C)C2=C(C)C=C(O)C(C=O)=C2O
別名

アトラノリン
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 12.5 mg/mL (33.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6714 mL

13.3568 mL

26.7137 mL

5 mM

0.5343 mL

2.6714 mL

5.3427 mL

10 mM

0.2671 mL

1.3357 mL

2.6714 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Melo MG, et al. Redox properties and cytoprotective actions of atranorin, a lichen secondary metabolite. Toxicol In Vitro. 2011 Mar;25(2):462-8. [Content Brief]

[2]. Semenov K N, et al. Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome. Journal of Molecular Liquids, 2024, 413: 125743.

[3]. Zhou R, et al. The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis. Sci Rep. 2017 Aug 15;7(1):8136. [Content Brief]

[4]. Barreto R S S, et al. Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents. Revista Brasileira de Farmacognosia, 2013, 23(2): 310-319.

[5]. Ranković B, et al. The antimicrobial activity of substances derived from the lichens Physcia aipolia, Umbilicaria polyphylla, Parmelia caperata and Hypogymnia physodes. World journal of microbiology and biotechnology, 2008, 24: 1239-1242.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6714 mL	13.3568 mL	26.7137 mL	66.7842 mL
	5 mM	0.5343 mL	2.6714 mL	5.3427 mL	13.3568 mL
	10 mM	0.2671 mL	1.3357 mL	2.6714 mL	6.6784 mL
	15 mM	0.1781 mL	0.8905 mL	1.7809 mL	4.4523 mL
	20 mM	0.1336 mL	0.6678 mL	1.3357 mL	3.3392 mL
	25 mM	0.1069 mL	0.5343 mL	1.0685 mL	2.6714 mL
	30 mM	0.0890 mL	0.4452 mL	0.8905 mL	2.2261 mL

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Atranorin

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