Batiraxcept
Based on 2 publication(s) in Google Scholar
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((KD <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 2268717-61-7
- 分子量:93.85 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Batiraxcept
More
生物活性
|
Axl |
Batiraxcept (2 μM; 24 h) inhibits the viability of chemoresistant endometrial cancer cells (ARK1, PUC198) and synergizes with 12.5 nM Paclitaxel (HY-B0015) to reduce glycolytic metabolites and pAKT signaling[1].
Batiraxcept (100 μg/mL; 24 h) reduces the invasion and migration ability of cholangiocarcinoma cells (SNU1196, HUCCT1) in Matrigel invasion and scratch assays[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:ARK1, PUC198 (human endometrial cancer)
-
Concentration:2 μM
-
Incubation Time:24 h
-
Result:Showed a 40-60% reduction in viability compared to control, with synergistic effect when combined with Paclitaxel.
Batiraxcept (50 mg/kg, 100 mg/kg; intraperitoneal injection; once every 2 days; 25 days) significantly reduces the dissemination of bile duct tumor cells in the peritoneal cavity in a mouse endometrial cancer (SNU1196 cell) xenograft model, and does not affect the body weight of immunodeficient mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice (female, 6-8 weeks old, 18-22 g), ARK1 cell-derived endometrial cancer xenograft model[1]
-
Dosage:30 mg/kg
-
Administration:Intraperitoneal injection (i.p.), twice weekly for 4 weeks, starting 1 week after tumor cell inoculation
-
Result:-Tumor Growth:
Tumor volume was measured by caliper every 3 days. At the end of the treatment, the average tumor volume in the Batiraxcept group was 60% smaller than that in the control group.
-Metastasis:
Lung metastasis was evaluated by counting the number of metastatic nodules after sacrifice. The number of metastatic nodules in the Batiraxcept group was reduced by 80% compared to the control group.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
[AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
化学情報
-
CAS 番号 2268717-61-7
-
性状 Liquid
-
分子量 93.85 kDa
-
Color Colorless to light yellow
-
SMILES
[Batiraxcept]
-
別名
AVB-500; AVB-S6-500
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Adv Sci (Weinh)
TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6-GAS6 Axis. [Abstract]2026 Apr;13(24):e20739. PMID: 41703992 -
Gynecol Oncol
AXL inhibition improves the therapeutic efficacy of trastuzumab in high-risk endometrial cancer. [Abstract]2025 Nov 20:204:52-62. PMID: 41270342
純度とドキュメンテーション
-
データシート (263 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Bruce SF, et al. GAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasing Tumor Cell Glycolysis. Mol Cancer Ther. 2022 Aug 2;21(8):1348-1359. [Content Brief]
[2]. Kim J, et al. Targeting AXL Using the AVB-500 Soluble Receptor and through Genetic Knockdown Inhibits Bile Duct Cancer Growth and Metastasis. Cancers (Basel). 2023 Mar 21;15(6):1882. [Content Brief]
[3]. Toboni MD, et al. Inhibition of AXL and VEGF-A Has Improved Therapeutic Efficacy in Uterine Serous Cancer. Cancers (Basel). 2021 Nov 23;13(23):5877. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Batiraxcept 関連分類
HY-P99463 関連分類
Powered by Bioz