BChE-IN-49
BChE-IN-49 is an orally active BChE inhibitor with IC50 values of 0.73 μM and 6.43 μM against BChE and AChE, respectively. BChE-IN-49 reduces AChE levels to inhibit the degradation of acetylcholine. By inhibiting GSK-3β, BChE-IN-49 potently activates the Wnt/β-catenin signaling pathway, exerting potent anti-Aβ, antioxidant, anti-neuroinflammatory and anti-apoptotic effects. BChE-IN-49 can be used in research related to Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H18ClNO2S
- 分子量:395.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BChE 0.73 μM () |
AChE 6.43 μM () |
Bax |
Bcl-2 |
IL-1β |
GSK-3β |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (adult male, 300-320 g, AlCl3-induced AD model)[1]
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Dosage:30 mg/kg
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Administration:p.o.; daily; 5 weeks (concurrent with AlCl3 i.p. dosing)
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Result:Effectively reversed the cognitive dysfunction induced by AlCl3 in rats.
Inhibited the key enzyme (BACE1) that generates Aβ to reduce Aβ deposition.
Significantly increased the level of BDNF, which had neuroprotective and repair effects.
Reduced levels of pro-inflammatory cytokines IL-1β and TNF-α.
Effectively inhibited neuronal apoptosis.
Strongly activated the Wnt/β-catenin neuroprotective pathway, while inhibiting its negative regulatory factor GSK-3β.
Significantly reversed the decline in DA, NE and 5-HT levels caused by AlCl3, restoring them by 4.5 times, 2.6 times and 5.6 times respectively.
化学情報
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分子量 395.90
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分子式 C22H18ClNO2S
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SMILES
O=C1N(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)OC4=C1C5=C(CCCC5)S4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE-IN-49 関連分類
HY-181248 関連分類
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