製品番号: HY-111244

DCB-3503

DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1.

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CAS 番号: 87302-58-7
分子式: C₂₄H₂₇NO₅
分子量:409.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DCB-3503 構造式

CAS 番号: 87302-58-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CDK アイソフォーム固有の製品をすべて表示 :

HSP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human 786-O cells after 72 hrs by SRB assay Antiproliferative activity against human 786-O cells after 72 hrs by SRB assay	[PMID: 28333459]
A549	GI₅₀	0.67 μM Compound: 16, DCB-3503	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
A549	IC₅₀	0.283 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay	[PMID: 28333459]
Bel-7402	IC₅₀	0.11 μM Compound: 1	Antiproliferative activity against human Bel7402 cells assessed as reduction in viability after 72 hrs by SRB assay Antiproliferative activity against human Bel7402 cells assessed as reduction in viability after 72 hrs by SRB assay	[PMID: 28333459]
Bel-7402	IC₅₀	0.11 μM Compound: 1; DCB-3503	Antiproliferative activity against human Bel-7402 cells after 72 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells after 72 hrs by SRB assay	[PMID: 31171403]
BEL-7404 tumor cell line	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Bel7404 cells after 72 hrs by SRB assay Antiproliferative activity against human Bel7404 cells after 72 hrs by SRB assay	[PMID: 28333459]
BXPC-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB assay Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB assay	[PMID: 28333459]
COLO 205	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human COLO205 cells after 72 hrs by SRB assay Antiproliferative activity against human COLO205 cells after 72 hrs by SRB assay	[PMID: 28333459]
Detroit 562	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Detroit 562 cells after 72 hrs by SRB assay Antiproliferative activity against human Detroit 562 cells after 72 hrs by SRB assay	[PMID: 28333459]
HCT-116	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 28333459]
HeLa	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 28333459]
Hep 3B2	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Hep3B cells after 72 hrs by SRB assay Antiproliferative activity against human Hep3B cells after 72 hrs by SRB assay	[PMID: 28333459]
HepG2	IC₅₀	1067 nM Compound: DCB-3503	Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay	[PMID: 17531481]
HepG2	IC₅₀	1067 nM Compound: DCB-3503	Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay	[PMID: 17531481]
HepG2	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 28333459]
HepG2 2.2.15	IC₅₀	98.9 nM Compound: DCB-3503	Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition	[PMID: 29317151]
HL-60	IC₅₀	0.213 μM Compound: 1; DCB-3503	Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 31171403]
HL-60	IC₅₀	212.8 nM Compound: 1	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 28333459]
HL60/MX2	IC₅₀	278.3 nM Compound: 1	Antiproliferative activity against human HL60/MX2 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60/MX2 cells after 72 hrs by MTT assay	[PMID: 28333459]
Huh-7	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HuH7 cells after 72 hrs by SRB assay Antiproliferative activity against human HuH7 cells after 72 hrs by SRB assay	[PMID: 28333459]
K562	IC₅₀	98.4 nM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 28333459]
K562/Adr	IC₅₀	137.5 nM Compound: 1	Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay	[PMID: 28333459]
KB	IC₅₀	58.2 nM Compound: 1	Antiproliferative activity against human KB cells after 72 hrs by SRB assay Antiproliferative activity against human KB cells after 72 hrs by SRB assay	[PMID: 28333459]
KB-V1	GI₅₀	30 nM Compound: 1	Growth inhibition of human KBV1 cells after 8 days by methylene blue-staining based spectrophotometry Growth inhibition of human KBV1 cells after 8 days by methylene blue-staining based spectrophotometry	[PMID: 28333459]
MCF7	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 28333459]
MDA-MB-157	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MDA-MB-157 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-157 cells after 72 hrs by SRB assay	[PMID: 28333459]
MDA-MB-231	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 28333459]
MKN-45	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MKN45 cells after 72 hrs by SRB assay Antiproliferative activity against human MKN45 cells after 72 hrs by SRB assay	[PMID: 28333459]
PC-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay	[PMID: 28333459]
RAW264.7	IC₅₀	36 nM Compound: 4, DCB-3503	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA	[PMID: 25221661]
RAW264.7	IC₅₀	53 nM Compound: 4, DCB-3503	Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay	[PMID: 25221661]
SGC-7901	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SGC7901 cells after 72 hrs by SRB assay Antiproliferative activity against human SGC7901 cells after 72 hrs by SRB assay	[PMID: 28333459]
SJRH30	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Rh30 cells after 72 hrs by SRB assay Antiproliferative activity against human Rh30 cells after 72 hrs by SRB assay	[PMID: 28333459]
SK-HEP1	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay	[PMID: 28333459]
SK-OV-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SKOV3 cells after 72 hrs by SRB assay Antiproliferative activity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 28333459]
SMMC-7721	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SMMC7721 cells after 72 hrs by SRB assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by SRB assay	[PMID: 28333459]
Splenocyte	IC₅₀	20 nM Compound: 4, DCB-3503	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 25221661]
Splenocyte	IC₅₀	97 nM Compound: 4, DCB-3503	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA	[PMID: 25221661]
SU-DHL-6	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SUDHL6 cells after 72 hrs by MTT assay Antiproliferative activity against human SUDHL6 cells after 72 hrs by MTT assay	[PMID: 28333459]
T47D	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human T47D cells after 72 hrs by SRB assay Antiproliferative activity against human T47D cells after 72 hrs by SRB assay	[PMID: 28333459]
U-118-MG	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human U118MG cells after 72 hrs by SRB assay Antiproliferative activity against human U118MG cells after 72 hrs by SRB assay	[PMID: 28333459]

化学情報

CAS 番号 87302-58-7
分子量 409.47
分子式 C₂₄H₂₇NO₅
SMILES

O[C@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70 [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DCB-3503

CDK アイソフォーム固有の製品をすべて表示

HSP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

DCB-3503 関連分類

HY-111244 関連分類