Sos1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

Also Known as 9630010N06; 4430401P03Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 20662

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including neuronal cell body; plasma membrane; and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sos1 Products (1)

mRNA Protein Name
NM_009231.2 NP_033257.2 son of sevenless homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables guanyl-nucleotide exchange factor activity EXP
EXP: Inferred from Experiment
15644420 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
7799946 MGI
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
7799946 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8479540 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15661907 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
24043312 MGI
involved in B cell receptor signaling pathway IGI
IGI: Inferred from genetic interaction
24043312 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within cardiac atrium morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
9030684 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
11585837 MGI
acts upstream of or within hair follicle development IGI
IGI: Inferred from genetic interaction
9030684 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within heart trabecula morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
7829473 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
33567274 MGI
acts upstream of or within lymphocyte homeostasis IGI
IGI: Inferred from genetic interaction
24043312 MGI
acts upstream of or within midbrain morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
9030684 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within pericardium morphogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within regulation of T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
24043312 MGI
acts upstream of or within regulation of T cell proliferation IGI
IGI: Inferred from genetic interaction
24043312 MGI
acts upstream of or within regulation of pro-B cell differentiation IGI
IGI: Inferred from genetic interaction
24043312 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
9030684 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 MGI
acts upstream of or within vitellogenesis IMP
IMP: Inferred from mutant phenotype
9030684 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

son of sevenless homolog 1

  • guanine nucleotide releasing factor

  • ras guanine exchange factor

  • son-of-sevenless 1

Sos1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Sos1 Q62245 Grb2 Mus musculus Q60631
Anti Bait CoIP
9569023
Intra
Sos1 Q62245 Grb2 Mus musculus Q60631
Anti Bait CoIP
8479540
Cross
Sos1 Q62245 polg_hcvbk Hepatitis C virus P26663
Fluorescence Spectr
15767257
Cross
Sos1 Q62245 polg_hcvbk Hepatitis C virus P26663
NMR
15767257
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
製品番号 製品名 製品効果
純度 Phase
HY-159127 HRS-4642 99.74% Phase 3
HY-145926 MRTX0902 Inhibitor 99.67% Phase 1
HY-134813A MRTX1133 formic Inhibitor 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (97)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-134813 MRTX1133 Inhibitor 99.97% Unkown
HY-125817 BI-3406 Inhibitor 99.95% Unkown
HY-114398 BAY-293 Inhibitor 98.97% Unkown
HY-134885 RMC-0331 Inhibitor 98.96% Unkown
HY-111671 VUBI1 98.21% Unkown
HY-161233A BTX-6654 formate 98.85% Unkown
HY-153606 VUBI1 analogue-1 98.94% Unkown
HY-P2265A SAH-SOS1A TFA Inhibitor 96.55% Unkown
HY-W056267 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde 98.0% Unkown
HY-151517 SOS1-IN-14 Inhibitor 99.60% Unkown
HY-161235 BTX-7312 98.35% Unkown
HY-163939 RGT-018 Inhibitor 99.77% Unkown
HY-144962 SOS1-IN-11 Inhibitor 98.22% Unkown
HY-145737A PROTAC SOS1 degrader-1 TFA 98.38% Unkown
HY-W115490 4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid 98.28% Unkown
HY-151881 SOS1-IN-15 Inhibitor 98.04% Unkown
HY-101796 NSC-70220 Inhibitor 99.42% Unkown
HY-161233 BTX-6654 / Unkown
HY-114398A (S)-BAY-293 97.8% Unkown
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% Unkown
HY-148278 BI-0474 Inhibitor 99.83% Unkown
HY-158310 SOS1/EGFR-IN-1 Inhibitor 99.54% Unkown
HY-RS13576 SOS1 Human Pre-designed siRNA Set A / Unkown
HY-144212 SOS1-IN-8 Inhibitor / Unkown
HY-122685 UC-773587 Inhibitor / Unkown
HY-124514 UC-857993 Inhibitor / Unkown
HY-124755 RAS activator compound 1 Activator 98.90% Unkown
HY-132129 SOS1-IN-2 Inhibitor / Unkown
HY-144207 SOS1-IN-9 Inhibitor / Unkown
HY-144210 SOS1-IN-6 Inhibitor / Unkown
HY-144211 SOS1-IN-7 Inhibitor / Unkown
HY-144213 SOS1-IN-10 Inhibitor / Unkown
HY-144657 (4S)-PROTAC SOS1 degrader-1 / Unkown
HY-144965 SOS1-IN-12 Inhibitor / Unkown
HY-144967 SOS1-IN-13 Inhibitor / Unkown
HY-145046 SOS1-IN-3 Inhibitor / Unkown
HY-145047 SOS1-IN-4 Inhibitor / Unkown
HY-145048 SOS1-IN-5 Inhibitor / Unkown
HY-145737 PROTAC SOS1 degrader-1 / Unkown
HY-148261 KRAS G12C inhibitor 56 Inhibitor / Unkown
HY-151968 KRAS G12C inhibitor 57 Inhibitor / Unkown
HY-152145 PROTAC SOS1 degrader-3 / Unkown
HY-153674 PROTAC SOS1 degrader-4 Degrader / Unkown
HY-153940 SOS1/KRAS-IN-1 Inhibitor / Unkown
HY-153989 SOS1-IN-16 Inhibitor / Unkown
HY-161173 PROTAC SOS1 degrader-5 / Unkown
HY-161236 KRAS ligand 4 Inhibitor / Unkown
HY-161450 LHF418 Inhibitor / Unkown
HY-161452 SOS1 Ligand intermediate-3 Inhibitor / Unkown
HY-161634 PROTAC SOS1 degrader-8 Degrader / Unkown
HY-161635 SOS1 Ligand intermediate-4 Inhibitor / Unkown
HY-161636 PROTAC SOS1 degrader-9 Degrader / Unkown
HY-161637 E3 ligase Ligand 25 / Unkown
HY-161639 E3 ligase Ligand 26 / Unkown
HY-161654 PROTAC SOS1 degrader-10 / Unkown
HY-161714 HH0043 Inhibitor / Unkown
HY-162281 PROTAC SOS1 degrader-6 / Unkown
HY-163582 PROTAC SOS1 degrader-7 / Unkown
HY-167768 SOS1 activator 2 / Unkown
HY-168514 SOS1/EGFR-IN-2 Inhibitor / Unkown
HY-168637 SIAIS562055 / Unkown
HY-168638 PROTAC SOS1 ligand 1 Inhibitor / Unkown
HY-168716 SOS1-IN-17 Inhibitor / Unkown
HY-169371 SOS1 Ligand intermediate-7 Inhibitor / Unkown
HY-172221 SOS1-IN-18 Inhibitor / Unkown
HY-173047 KRASG12C IN-15 Inhibitor / Unkown
HY-173341 SOF-436 Inhibitor / Unkown
HY-175244 SOS1-IN-20 Inhibitor / Unkown
HY-175326 SOS1-IN-21 Inhibitor / Unkown
HY-175560 SOS1-IN-22 Inhibitor / Unkown
HY-175575 SOS1 ligand-2 Ligand / Unkown
HY-175891 POI ligand-5 / Unkown
HY-176170 SOS1-IN-19 Inhibitor / Unkown
HY-176789 VUBI1-octanoic acid Inhibitor / Unkown
HY-178044 SOS1-IN-24 Inhibitor / Unkown
HY-179414 KRAS G12D-IN-34 Inhibitor / Unkown
HY-179443 SOS1-IN-25 Inhibitor / Unkown
HY-181807 SOS1/KRAS-IN-2 / Unkown
HY-182411 KRAS-IN-56 Inhibitor / Unkown
HY-183365 SL43 Inhibitor / Unkown
HY-184422 SOS1-IN-26 / Unkown
HY-184423 SOS1-IN-27 / Unkown
HY-184586 SOS1-IN-28 Inhibitor / Unkown
HY-184855 (S,S,S,S)-AHPC-Me / Unkown
HY-184930 SOS1 ligand-4 Ligand / Unkown
HY-19539 NSC-658497 Inhibitor / Unkown
HY-P2265 SAH-SOS1A Inhibitor / Unkown
HY-112078B (S,S,S)-AHPC-Me / Unkown
HY-161638 E3 Ligase Ligand-linker Conjugate 108 / Unkown
HY-161640 E3 Ligase Ligand-linker Conjugate 109 / Unkown
HY-161655 SOS1 Ligand intermediate-5 Inhibitor / Unkown
HY-161656 PIP-C-3-Azaspiro[5.5]undecane-boc / Unkown
HY-161657 2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP / Unkown
HY-163583 SOS1 Ligand intermediate-6 Inhibitor / Unkown
HY-RS16568 Sos1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS23001 Sos1 Rat Pre-designed siRNA Set A / Unkown
HY-RS26460 Sos2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Sos1 NCBI NCBI:6654