製品番号: HY-N8389

Globulol

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Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.74%
CAS 番号: 489-41-8
分子式: C₁₅H₂₆O
分子量:222.37

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Globulol 構造式

CAS 番号: 489-41-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

PAK4

STAT3

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体外実験

Globulol (0-320 μM; 24 h) reduces the viability of Huh1 and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner, with IC₅₀ values of 136.6 μM and 141.5 μM, respectively^[1].
Globulol (40-120 μM; 24 h) induces G₀/G₁ cell cycle arrest in Huh1 and Huh7 hepatocellular carcinoma cells^[1].
Globulol (40-120 μM) induces apoptosis in Huh1 and Huh7 hepatocellular carcinoma cells in a dose-dependent manner^[1].
Globulol (40-120 μM; 12 h) inhibits the migratory capacity of Huh1 and Huh7 hepatocellular carcinoma cells in 3D tumor spheroid models^[1].
Globulol (80 μM) enhances the migratory capacity of activated CD8⁺ T cells toward Huh1 and Huh7 hepatocellular carcinoma cells by upregulating the expression of CCL4 during a 24-hour co-cultivation process^[1].
Globulol (80 μM; 24 h) enhances CD8⁺ T cell-mediated cytotoxicity against 3D spheroids of Huh7 hepatocellular carcinoma cells during a 24-hour co-culture process^[1].
Globulol (40-120 μM) inhibits the PAK4-pAKT-STAT3 pathway and reduces the expression of PD-L1 protein in wild-type, PAK4-overexpressing and PAK4-knockdown Huh7 hepatocellular carcinoma cells^[1].
Globulol inhibits the growth of Xanthomonas vesicatoria and Bacillus subtilis, with an IC₅₀ of 158.0 μg mL⁻¹ against the former and 737.2 μg mL⁻¹ against the latter^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Huh1, Huh7, LX-2 human hepatic stellate cells
Concentration:

0-320 μM (Huh1, Huh7); 30-160 μM (LX-2)
Incubation Time:

24 h
Result:

Significantly reduced the viability of Huh1 and Huh7 cells in a concentration-dependent manner, with IC₅₀ values of 136.6 μM (Huh1) and 141.5 μM (Huh7) (P < 0.001).
Caused no notable viability changes in LX-2 cells at concentrations ranging from 30 to 160 μM (P > 0.05).

Cell Cycle Analysis^[1]

Cell Line:

Huh1, Huh7 hepatocellular carcinoma cells
Concentration:

40-120 μM
Incubation Time:

24 h
Result:

Caused a substantial, dose-dependent increase in the G0/G1 phase fraction of both Huh1 and Huh7 cells compared to controls (P < 0.001).

Cell Migration Assay ^[1]

Cell Line:

Huh1, Huh7 hepatocellular carcinoma cells
Concentration:

40-120 μM
Incubation Time:

12 h
Result:

Reduced the density of migrating cells from tumor spheroids in a dose-dependent manner.
Made tumor spheroid boundaries well-defined with few migrating cells at 120 μM.
Significantly reduced the relative invasion area in both Huh1 (P < 0.01) and Huh7 (P < 0.001) cells compared to controls.

Western Blot Analysis^[1]

Cell Line:

Huh7 hepatocellular carcinoma cells (wild-type, PAK4-overexpressing, and PAK4-knockdown)
Concentration:

40-120 μM (wild-type cells); 120 μM (PAK4-overexpressing and PAK4-knockdown cells)
Incubation Time:

A certain period of time
Result:

Dose-dependently reduced protein levels of PAK4, p-AKT (Ser473), STAT3, p-STAT3 (Y705), and PD-L1 in wild-type Huh7 cells, with no notable effect on total AKT levels.
Reduced protein levels of PAK4, p-AKT (Ser473), STAT3, p-STAT3 (Y705), and PD-L1 in PAK4-overexpressing Huh7 cells.
Further reduced protein levels of PAK4, STAT3, p-STAT3 (Y705), and PD-L1 in PAK4-knockdown Huh7 cells compared to the knockdown-only group.

化学情報

CAS 番号 489-41-8
性状 Solid
分子量 222.37
分子式 C₁₅H₂₆O
Color White to off-white
SMILES

CC1([C@@]2([H])[C@@]3([H])[C@](CC[C@H]3C)([H])[C@](O)(CC[C@]21[H])C)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (285 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang Z, et al. Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma. Front Pharmacol. 2026 Feb 20;17:1728692. [Content Brief]

[2]. Tan M, et al. Antimicrobial activity of globulol isolated from the fruits of Eucalyptus globulus Labill. Nat Prod Res. 2008 May 10;22(7):569-75. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Globulol

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

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Oxygen Sensing Compound Library

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Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Protein-protein Interaction Inhibitor Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Chemokine Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

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Protein Kinase Compound Library

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High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

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