Cat. No.: HY-18981

Decursin

(Synonyms: (+)-Decursin)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.92%
CAS No.: 5928-25-6
화학식: C₁₉H₂₀O₅
분자량:328.36

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Decursin Chemical Structure

CAS No.: 5928-25-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PKC Isoforms :

All CXCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	175.9 μM Compound: 2	Inhibition of Wnt/beta-catenin pathway in human HEK293 cells after 15 hrs by TOPflash dual luciferase reporter gene assay Inhibition of Wnt/beta-catenin pathway in human HEK293 cells after 15 hrs by TOPflash dual luciferase reporter gene assay	[PMID: 27329797]

In Vitro

Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) inhibits cell growth in a dose- and time- dependent manner in DU145 cells^[1].
Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) induces apoptosis and cell cycle arrest at G1 phase in DU145 cells, G1, S as well as G2-M arrests in PC-3 cells^[1].
Decursin (0, 25, 50, 100 μM; 24, 48 h) decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h in DU145 cells^[1].
Decursin (0, 5, 20, 100 μM; 7 days) inhibits the proliferation and differentiation ability of AC133+ cells^[2].
Decursin (0, 5, 20, 100 μM) inhibits SDF-1a-induced activation of Akt, ERK1/2, and eNOS in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

DU145 cells
Concentration:

0, 25, 50, 100 µM
Incubation Time:

24, 28, 72, 96 h
Result:

Showed a dose- and time- dependent inhibition cell growth with 22% to 51%, 21%to 68%, 9% to 72%, 42% to 90% growth inhibition after 24, 48, 72, and 96 hours oftreatment, respectively. And caused 15%-45% cell death.

Cell Cycle Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0, 25, 50, 100 µM
Incubation Time:

12-96 h
Result:

Caused 52%, 65%, and 78% DU145 cells in G1phase.

Western Blot Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0, 25, 50, 100 µM
Incubation Time:

24, 48 h
Result:

Did not show any any alteration inprotein levels of CDK2, CDK4, CDK6, cyclin D1, and cyclin E, but dose-dependent decreased in the expression of these proteins except cyclin E at 48 h.

In Vivo

Decursin (4 mg/kg; s.c.; daily for 4 weeks) shows anti-tumor activity in mouse^[2].
Decursin (50 mg/kg; intrathecal injection; three times at 2-day intervals, for 6 days) shows analgesic ability in paclitaxel-induced peripheral neuropathy in mouse^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (LLC cells)^[2]
Dosage:

4 mg/kg
Administration:

S.c.; daily for 4 weeks
Result:

Delayed tumor formation and dramatically decreased tumor growth by inhibition of angiogenesis through VEGFR-2 signaling pathway.

Animal Model:

Eight-week-old adult C57BL/6J male and female mice^[3]
Dosage:

50 mg/kg
Administration:

Intrathecal injection; three times at 2-day intervals, for 6 days
Result:

Demonstrated the analgesic ability in the in vivo model of paclitaxel-induced peripheral neuropathy.

Chemical Information

CAS No. 5928-25-6
Appearance Solid
분자량 328.36
화학식 C₁₉H₂₀O₅
Color White to off-white
SMILES

C/C(C)=C\C(O[C@H](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O
Synonyms

(+)-Decursin
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
- Plants
- Umbelliferae
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Eur J Pharmacol

Decursin, a bioactive compound from Angelica gigas, suppresses mast cell activation by targeting Fyn kinase and attenuates IgE-mediated anaphylactic responses in mice. [Abstract]

2026 Mar 11:1019:178780. PMID: 41825715
Int Immunopharmacol

Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway. [Abstract]

2021 Aug:97:107657. PMID: 33878544

용액&용해도

In Vitro:

DMSO : 50 mg/mL (152.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0454 mL

15.2272 mL

30.4544 mL

5 mM

0.6091 mL

3.0454 mL

6.0909 mL

10 mM

0.3045 mL

1.5227 mL

3.0454 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005 Feb 1;65(3):1035-44. [Content Brief]

[2]. Jung SY, et al. Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function. J Cell Biochem. 2012 May;113(5):1478-87. [Content Brief]

[3]. Son DB, et al. Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model. Cells. 2021 Mar 4;10(3):547. [Content Brief]

[4]. Ahn KS, et al. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 1996 Feb;62(1):7-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0454 mL	15.2272 mL	30.4544 mL	76.1360 mL
	5 mM	0.6091 mL	3.0454 mL	6.0909 mL	15.2272 mL
	10 mM	0.3045 mL	1.5227 mL	3.0454 mL	7.6136 mL
	15 mM	0.2030 mL	1.0151 mL	2.0303 mL	5.0757 mL
	20 mM	0.1523 mL	0.7614 mL	1.5227 mL	3.8068 mL
	25 mM	0.1218 mL	0.6091 mL	1.2182 mL	3.0454 mL
	30 mM	0.1015 mL	0.5076 mL	1.0151 mL	2.5379 mL
	40 mM	0.0761 mL	0.3807 mL	0.7614 mL	1.9034 mL
	50 mM	0.0609 mL	0.3045 mL	0.6091 mL	1.5227 mL
	60 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2689 mL
	80 mM	0.0381 mL	0.1903 mL	0.3807 mL	0.9517 mL
	100 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7614 mL

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Decursin

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Publications Citing Use of MedChemExpress (MCE) Decursin

All PKC Isoforms

All CXCR Isoforms

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Decursin Related Classifications

HY-18981 Related Classifications