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Cat. No.: HY-134303

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CST651

(Synonyms: PROTAC CDK4/6 degrader 34)

CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC₅₀ values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia.
(Pink: Cdk4/cyclin D3 and Cdk4/cyclin D1 and Cdk6/cyclin D2 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2489241-16-7
화학식: C₅₆H₇₂FN₁₁O₉S
분자량:1094.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CST651 Chemical Structure

CAS No.: 2489241-16-7

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC₅₀ values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia^[1]. (Pink: Cdk4/cyclin D3 and Cdk4/cyclin D1 and Cdk6/cyclin D2 ligand (HY-50767); Blue: VHL ligand (HY-125905); Black: linker (HY-W017440)).

IC₅₀ & Target^[1]

CDK6

5.1 nM (DC₅₀, In MM.1S cells)

CDK4

20 nM (DC₅₀, In MM.1S cells)

VHL

All PROTACs Isoforms :

All CDK Isoforms :

Chemical Information

CAS No. 2489241-16-7
분자량 1094.30
화학식 C₅₆H₇₂FN₁₁O₉S
SMILES

O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCN(CCOCCOCCOC6=CC(C7=C(C)N=CS7)=CC=C6CNC([C@H]8N(C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)C[C@H](O)C8)=O)CC5)C=N4)C
Synonyms

PROTAC CDK4/6 degrader 34
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Steinebach C, et al. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chem Sci. 2020 Mar 4;11(13):3474-3486. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
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CST651

All PROTACs Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CST651 Related Classifications

HY-134303 Related Classifications