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Cat. No.: HY-107150R

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Reproxalap (Standard)

(Synonyms: ADX-102 (Standard); NS-2 (Standard))

Reproxalap (Standard) (ADX-102 (Standard)) is the analytical standard of Reproxalap (HY-107150). This product is intended for research and analytical applications. Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis.

For research use only. We do not sell to patients.

CAS No.: 916056-79-6
Formula: C₁₂H₁₃ClN₂O
Molecular Weight:236.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Reproxalap (Standard) Chemical Structure

CAS No.: 916056-79-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PKC Isoforms :

All Caspase Isoforms :

Chemical Information

CAS No. 916056-79-6
Molecular Weight 236.70
Formula C₁₂H₁₃ClN₂O
SMILES

CC(C1=NC2=C(C=C(Cl)C=C2)C=C1N)(O)C
Synonyms

ADX-102 (Standard); NS-2 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ochoa CA, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022 Mar 2;12(3):393. [Content Brief]

[2]. Rizzo WB, et al. Sjögren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents. Mol Genet Metab Rep. 2021 Dec 23;30:100839. [Content Brief]

[3]. Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.

[4]. Reproxalap Phase 2b Dry Eye Disease Results.

[5]. Susan G. Macdonald, Ph.D., et al. Novel Small Molecule Aldehyde Sequestering Agents Demonstrate Broad Therapeutic Potential for Ocular Inflammation.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Reproxalap (Standard)

All PKC Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Reproxalap (Standard) Related Classifications

HY-107150R Related Classifications