147 Results for "

inflammatory component

" in MedChemExpress (MCE) Product Catalog:
Products (147)

147 Results for "inflammatory component" in MCE Product Catalog:

91
Capsaicin
Capsaicin
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91 Publications Verification
Cat. No.: HY-10448
CAS No.: 404-86-4
Purity:  99.79%
Synonyms: (E)-Capsaicin
Category:  

Capsicum annuum L. Monophenols Phenols Plants Disease Research Fields Biological Pesticide Research Cancer Solanaceae Extract Agricultural Research

Target:  

Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
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30
Infliximab
Infliximab
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30 Cited Publications
Cat. No.: HY-P9970
CAS No.: 170277-31-3
Synonyms: Avakine; CT-P13; SB2; TA-650

Target:  

TNF Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .
The component ratio of this product is Active ingredient : Excipients = 9 : 47.
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16
18β-Glycyrrhetinic acid
18β-Glycyrrhetinic acid
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16 Cited Publications
Cat. No.: HY-N0180
CAS No.: 471-53-4
Category:  

Triterpenes Terpenoids Leguminosae Extract Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Endogenous Metabolite

18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
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12
Ginsenoside Rk1
Ginsenoside Rk1
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12 Cited Publications
Cat. No.: HY-N2515
CAS No.: 494753-69-4
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Extract

Target:  

NF-κB PI3K JAK Apoptosis

Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .
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12
Higenamine
Higenamine
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12 Cited Publications
Cat. No.: HY-N2037
CAS No.: 5843-65-2
Synonyms: Norcoclaurine; Demethyl-Coclaurine
Category:  

Alkaloids Phenols Polyphenols Plants Aconitum carmichaeli Debx. Extract Disease Research Fields Isoquinoline Alkaloids Endocrinology Ranunculaceae Extract

Target:  

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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11
Aucubin
Aucubin
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11 Cited Publications
Cat. No.: HY-N0664
CAS No.: 479-98-1
Category:  

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Plants Disease Research Fields Inflammation/Immunology Eucommiaceae Extract

Target:  

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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9
Olive oil
Olive oil
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9 Cited Publications
Cat. No.: HY-108749
CAS No.: 8001-25-0
Synonyms: Cropure OL
Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree . Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease .
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8
AMY-101
AMY-101
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8 Cited Publications
Cat. No.: HY-P1717
CAS No.: 1427001-89-5
Synonyms: Cp40
Target:  

Complement System SARS-CoV

Research Areas:  

Inflammation/Immunology

AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
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8
AMY-101 acetate
AMY-101 acetate
0 Images
8 Cited Publications
Cat. No.: HY-P1717B
Synonyms: Cp40 acetate
Target:  

Complement System SARS-CoV

Research Areas:  

Inflammation/Immunology

AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
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8
AMY-101 TFA
AMY-101 TFA
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8 Cited Publications
Cat. No.: HY-P1717A
CAS No.: 1789738-04-0
Synonyms: Cp40 TFA
Target:  

Complement System SARS-CoV

Research Areas:  

Inflammation/Immunology

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
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6
Safranal
Safranal
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6 Cited Publications
Cat. No.: HY-N7560
CAS No.: 116-26-7
Category:  

Ketones, Aldehydes, Acids Plants Crocus sativus L. Lridaceae Extract

Target:  

Keap1-Nrf2

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research .
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5
Curcumenol
Curcumenol
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5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Category:  

Neurological Disease Zingiberaceae Extract Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Cancer

Target:  

Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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4
Moracin M
Moracin M
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4 Cited Publications
Cat. No.: HY-122942
CAS No.: 56317-21-6
Purity:  98.90%
Category:  

Moraceae Extract Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Morus alba Linn.

Target:  

Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy

Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .
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4
Epimedin A
Epimedin A
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4 Cited Publications
Cat. No.: HY-N0257
CAS No.: 110623-72-8
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Disease Research Fields Berberidaceae Extract

Target:  

PI3K Akt NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Heme Oxygenase (HO) SOD Caspase Interleukin Related

Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases .
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4
Tenuigenin
Tenuigenin
0 Images
4 Cited Publications
Cat. No.: HY-N0802
CAS No.: 2469-34-3
Synonyms: Senegenin
Category:  

Triterpenes Terpenoids Polygalaceae Extract Plants Disease Research Fields Inflammation/Immunology Polygala tenuifolia Willd.

Target:  

NF-κB Bacterial

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .
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3
Capsaicin (Standard)
Capsaicin (Standard)
0 Images
3 Cited Publications
Cat. No.: HY-10448R
CAS No.: 404-86-4
Purity:  99.38%
Synonyms: (E)-Capsaicin (Standard)
Category:  

Capsicum annuum L. Phenols Plants Disease Research Fields Biological Pesticide Research Cancer Solanaceae Extract Agricultural Research

Target:  

Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite

Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
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3
Tussilagone
Tussilagone
0 Images
3 Cited Publications
Cat. No.: HY-N1388
CAS No.: 104012-37-5
Category:  

Terpenoids Sesquiterpenes Plants Compositae Extract Disease Research Fields Inflammation/Immunology Tephrosia purpurea (L.) Pers.

Target:  

Others

Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .
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3
Asatone
Asatone
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3 Cited Publications
Cat. No.: HY-N6826
CAS No.: 38451-63-7
Category:  

Asarum sieboldii Miq. Natural Products Aristolochiaceae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .
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3
Cotinine
Cotinine
0 Images
3 Cited Publications
Cat. No.: HY-B1178
CAS No.: 486-56-6
Synonyms: (-)-Cotinine; (S)-Cotinine; NIH-10498
Category:  

Alkaloids Pyrrole Alkaloids Nicotiana tabacum L. Other Diseases Pyridine Alkaloids Plants Endogenous metabolite Disease Research Fields Solanaceae Extract

Target:  

Endogenous Metabolite nAChR

Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
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2
Eleutheroside E
Eleutheroside E
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2 Cited Publications
Cat. No.: HY-N0272
CAS No.: 39432-56-9
Category:  

Lignans Acanthopanax senticosus (Rupr. et Maxim.) Harms Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Extract

Target:  

Apoptosis NF-κB

Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects .
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