2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

Related Products

PDF 1.04 MB

Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0150A
    Nicotinamide hydrochloride
    		Inhibitor
    Nicotinamide hydrochloride is a form of vitamin B3 or niacin. Nicotinamide hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide hydrochloride also inhibits SIRT1. Nicotinamide hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide hydrochloride inhibits tumor growth and improves survival. Nicotinamide hydrochloride also has anti-HBV activity.
    Nicotinamide hydrochloride
  • HY-160944
    hsa62
    		Inhibitor
    hsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC50 of 1.3 and 5.5 μM, respectively.
    hsa62
  • HY-149524
    SIRT5 inhibitor 8
    		Inhibitor
    SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50: 5.38 μM) of sirtuin SIRT5 with anticancer potential.
    SIRT5 inhibitor 8
  • HY-151185
    Sirt2-IN-7
    		Inhibitor
    Sirt2-IN-7 (compound 22) is a selective inhibitor of SIRT2. Sirt2-IN-7 inhibits SIRT2 with an IC50 value and a Ki value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer.
    Sirt2-IN-7
  • HY-149425
    SIRT5 inhibitor 6
    		Inhibitor
    SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo.
    SIRT5 inhibitor 6
  • HY-116095
    CypD-IN-5
    		Inhibitor
    CypD-IN-5 (compound C-9) is a potent cyclophilin D (CypD) inhibitor. CypD-IN-5 can be used in the study of Alzheimer's disease.
    CypD-IN-5
  • HY-124946
    C1A
    		Inhibitor
    C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells.
    C1A
  • HY-B0150G
    Nicotinamide (GMP)
    		Inhibitor
    Nicotinamide (GMP) (Niacinamide (GMP)) is the GMP level of Nicotinamide (HY-B0150). GMP guidelines are used to produce Nicotinamide (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
    Nicotinamide (GMP)
  • HY-139144
    YM-08
    		Inhibitor
    YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70.
    YM-08
  • HY-152214
    SIRT5 inhibitor 5
    		Inhibitor
    SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor.
    SIRT5 inhibitor 5
  • HY-162252
    SIRT2-IN-12
    		Inhibitor
    SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC50 value of 50 μM.
    SIRT2-IN-12
  • HY-149525
    SIRT5 inhibitor 9
    		Inhibitor
    SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor (IC50: 4.07 μM) of sirtuin SIRT5 with anticancer potential.
    SIRT5 inhibitor 9
  • HY-RS12955
    Sirt7 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt7 Rat Pre-designed siRNA Set A
  • HY-155392
    Mz325
    		Inhibitor 98.10%
    Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration.
    Mz325
  • HY-146013
    Sirt1/2-IN-1
    		Inhibitor
    Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.
    Sirt1/2-IN-1
  • HY-169051
    SIRT-IN-5
    		Inhibitor
    SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
    SIRT-IN-5
  • HY-153509
    Sirtuin-IN-1
    		Inhibitor
    Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma.
    Sirtuin-IN-1
  • HY-148312
    Sirtuin modulator 4
    		Inhibitor
    Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer.
    Sirtuin modulator 4
  • HY-149638
    HSP70/SIRT2-IN-2
    		Inhibitor
    HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity.
    HSP70/SIRT2-IN-2
  • HY-169809
    SIRT1-IN-5
    		Inhibitor
    SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator.
    SIRT1-IN-5
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.