Cat. No.: HY-N8389

Globulol

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Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma.

For research use only. We do not sell to patients.

Purity: 99.74%
CAS No.: 489-41-8
Formula: C₁₅H₂₆O
Molecular Weight:222.37

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Globulol Chemical Structure

CAS No.: 489-41-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PAK4

STAT3

All PAK Isoforms :

All Akt Isoforms :

All STAT Isoforms :

All CCR Isoforms :

In Vitro

Globulol (0-320 μM; 24 h) reduces the viability of Huh1 and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner, with IC₅₀ values of 136.6 μM and 141.5 μM, respectively^[1].
Globulol (40-120 μM; 24 h) induces G₀/G₁ cell cycle arrest in Huh1 and Huh7 hepatocellular carcinoma cells^[1].
Globulol (40-120 μM) induces apoptosis in Huh1 and Huh7 hepatocellular carcinoma cells in a dose-dependent manner^[1].
Globulol (40-120 μM; 12 h) inhibits the migratory capacity of Huh1 and Huh7 hepatocellular carcinoma cells in 3D tumor spheroid models^[1].
Globulol (80 μM) enhances the migratory capacity of activated CD8⁺ T cells toward Huh1 and Huh7 hepatocellular carcinoma cells by upregulating the expression of CCL4 during a 24-hour co-cultivation process^[1].
Globulol (80 μM; 24 h) enhances CD8⁺ T cell-mediated cytotoxicity against 3D spheroids of Huh7 hepatocellular carcinoma cells during a 24-hour co-culture process^[1].
Globulol (40-120 μM) inhibits the PAK4-pAKT-STAT3 pathway and reduces the expression of PD-L1 protein in wild-type, PAK4-overexpressing and PAK4-knockdown Huh7 hepatocellular carcinoma cells^[1].
Globulol inhibits the growth of Xanthomonas vesicatoria and Bacillus subtilis, with an IC₅₀ of 158.0 μg mL⁻¹ against the former and 737.2 μg mL⁻¹ against the latter^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Huh1, Huh7, LX-2 human hepatic stellate cells
Concentration:

0-320 μM (Huh1, Huh7); 30-160 μM (LX-2)
Incubation Time:

24 h
Result:

Significantly reduced the viability of Huh1 and Huh7 cells in a concentration-dependent manner, with IC₅₀ values of 136.6 μM (Huh1) and 141.5 μM (Huh7) (P < 0.001).
Caused no notable viability changes in LX-2 cells at concentrations ranging from 30 to 160 μM (P > 0.05).

Cell Cycle Analysis^[1]

Cell Line:

Huh1, Huh7 hepatocellular carcinoma cells
Concentration:

40-120 μM
Incubation Time:

24 h
Result:

Caused a substantial, dose-dependent increase in the G0/G1 phase fraction of both Huh1 and Huh7 cells compared to controls (P < 0.001).

Cell Migration Assay ^[1]

Cell Line:

Huh1, Huh7 hepatocellular carcinoma cells
Concentration:

40-120 μM
Incubation Time:

12 h
Result:

Reduced the density of migrating cells from tumor spheroids in a dose-dependent manner.
Made tumor spheroid boundaries well-defined with few migrating cells at 120 μM.
Significantly reduced the relative invasion area in both Huh1 (P < 0.01) and Huh7 (P < 0.001) cells compared to controls.

Western Blot Analysis^[1]

Cell Line:

Huh7 hepatocellular carcinoma cells (wild-type, PAK4-overexpressing, and PAK4-knockdown)
Concentration:

40-120 μM (wild-type cells); 120 μM (PAK4-overexpressing and PAK4-knockdown cells)
Incubation Time:

A certain period of time
Result:

Dose-dependently reduced protein levels of PAK4, p-AKT (Ser473), STAT3, p-STAT3 (Y705), and PD-L1 in wild-type Huh7 cells, with no notable effect on total AKT levels.
Reduced protein levels of PAK4, p-AKT (Ser473), STAT3, p-STAT3 (Y705), and PD-L1 in PAK4-overexpressing Huh7 cells.
Further reduced protein levels of PAK4, STAT3, p-STAT3 (Y705), and PD-L1 in PAK4-knockdown Huh7 cells compared to the knockdown-only group.

Chemical Information

CAS No. 489-41-8
Appearance Solid
Molecular Weight 222.37
Formula C₁₅H₂₆O
Color White to off-white
SMILES

CC1([C@@]2([H])[C@@]3([H])[C@](CC[C@H]3C)([H])[C@](O)(CC[C@]21[H])C)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma. Front Pharmacol. 2026 Feb 20;17:1728692. [Content Brief]

[2]. Tan M, et al. Antimicrobial activity of globulol isolated from the fruits of Eucalyptus globulus Labill. Nat Prod Res. 2008 May 10;22(7):569-75. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Globulol

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

GPCR/G Protein Compound Library

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All PAK Isoforms