BC-1471
Based on 1 publication(s) in Google Scholar
BC-1471 is a STAMBP deubiquitinase inhibitor with an IC50 of 0.33 μM. BC-1471 can inhibit the activity of the NALP7 inflammasome. BC-1471 has anti-inflammatory activity and can be used for the research of inflammatory diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.69%
- CAS No.: 896683-84-4
- Formule: C27H32N4O4S
- Masse moléculaire:508.63
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BC-1471
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Activité biologique
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IL-1β |
Caspase-1 |
BC-1471 (0.1-10 μM; 6-8 h) reduces LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced NALP7 protein levels and caspase-1 activation in THP-1 cells[1].
BC-1471 (0-10 μM; 4 h) inhibits LPS (HY-D1056) or Pam3CSK4 (HY-P1180)-induced IL-1β release in human PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056) or Pam3CSK4 (HY-P1180) treated THP-1 cells
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Concentration:0.1, 1 and 10 μM
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Incubation Time:6 h
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Result:Inhibited the protein levels of NALP7.
Chemical Information
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CAS No. 896683-84-4
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Appearance Solid
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Masse moléculaire 508.63
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Formule C27H32N4O4S
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Color White to off-white
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SMILES
O=C(NCC1OCCC1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
DMSO : 50 mg/mL (98.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9661 mL | 9.8303 mL | 19.6607 mL | 49.1516 mL |
| 5 mM | 0.3932 mL | 1.9661 mL | 3.9321 mL | 9.8303 mL | |
| 10 mM | 0.1966 mL | 0.9830 mL | 1.9661 mL | 4.9152 mL | |
| 15 mM | 0.1311 mL | 0.6554 mL | 1.3107 mL | 3.2768 mL | |
| 20 mM | 0.0983 mL | 0.4915 mL | 0.9830 mL | 2.4576 mL | |
| 25 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL | 1.9661 mL | |
| 30 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6384 mL | |
| 40 mM | 0.0492 mL | 0.2458 mL | 0.4915 mL | 1.2288 mL | |
| 50 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.9830 mL | |
| 60 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL | |
| 80 mM | 0.0246 mL | 0.1229 mL | 0.2458 mL | 0.6144 mL |
BC-1471 Related Classifications
HY-122883 Related Classifications
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