BDE30671203
BDE30671203 is a highly selective PLK1 inhibitor (IC50 = 2.163 nM). BDE30671203 induces G2/M phase arrest and Apoptosis. BDE30671203 downregulates key cell cycle regulators (CDC20, CDK1) and the anti-apoptotic gene Bcl-2. BDE30671203 exhibits anticancer activity against non-small cell lung cancer, large cell lung cancer, and liver cancer.
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- Formule: C26H34N8O
- Masse moléculaire:474.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
PLK1 2.163 nM (IC50) |
PLK2 >10000 nM (IC50) |
PLK3 >10000 nM (IC50) |
CDK1 |
Bcl-2 |
Chemical Information
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Masse moléculaire 474.60
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Formule C26H34N8O
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SMILES
O=C(N1CC(CC2=NC(N3CCN(C)CC3)=CC(NC4=CC(C)=NN4)=N2)CCC1)C5=CC=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BDE30671203 Related Classifications
HY-181030 Related Classifications
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